Industry Guanidine Hydrochloride stands as a prominent raw material in chemical manufacturing, shaping processes in pharmaceuticals, agrochemicals, textile industries, and lab synthesis. Identified by its HS Code 29252900, this chemical—known by the molecular formula CH6ClN3—combines guanidine with hydrochloric acid, producing a substance recognized both for its reactivity and reliability in controlled environments.
This compound features clear diversity in its presentation. Whether appearing as sharp, translucent crystals, fine white powder, compacted pearls, angular flakes, or clear solutions, each form carries distinct advantages for batching and storage. Solid forms—powder or crystalline—allow precise weighing and measurement, a vital consideration where reaction stoichiometry cannot be compromised. Densities tend to span 1.19 to 1.20 g/cm³, enabling users to readily estimate mass-by-volume when prepping solutions. In laboratories, 6M or 8M guanidine hydrochloride solutions support protein refolding and denaturation, owing to their strong chaotropic properties.
Guanidine hydrochloride presents as a strong base, yet its hydrochloride salt form enhances solubility in water and certain polar solvents. When dissolved, the solution tastes slightly saline and may feel cool due to endothermic dissolution. In solid state, the white crystals offer stable, predictable reactivity, critical in peptide synthesis and nucleic acid isolation. With a formula weight of 95.53 g/mol, calculations for reaction planning become straightforward. Molecules align in compact lattice structures, supporting long-term storage in controlled environments without significant degradation.
Pharmaceutical production relies on this compound to create intermediates for cardiovascular drugs and antiviral therapies. It provides strong denaturing action, disrupting hydrogen bonds in proteins—crucial during protein purification and refolding. Textile engineers turn to guanidine hydrochloride for dye fixation, letting synthetic fabrics retain vibrant color. Agrichemical synthesis benefits from its reactivity, producing herbicides and fungicides that boost crop yields and protect food supplies worldwide. In research, it works as a chaotropic agent, helping scientists unpick the mysteries of protein folding and DNA isolation. Price and availability reflect broad utility—factories often source metric tons annually for continuous production.
Consistency is crucial. Industry supply demands tight control on purity—typically above 99%—to prevent reaction side products or contamination in sensitive syntheses. Particle sizing varies: powder suits mass batch creation, flakes simplify manual handling, and pearlized forms provide dust-free options for automation. Specific gravity not only predicts settling in suspension but also helps with shipping regulations, enabling safe, cost-effective delivery worldwide. Each shipment receives robust packaging, protecting material integrity and worker health from the corrosive, irritant nature of the chemical.
Exposure to guanidine hydrochloride can irritate skin, eyes, and respiratory systems. Dust and solutions demand gloves and goggles at a minimum. Workers need robust local ventilation, especially during mixing or transfer, to contain airborne particles. Fire does not easily start in pure material, but if heated to decomposition, toxic fumes can emerge—emphasizing the need for adherence to safety data certifications. As a hazardous chemical, transport meets international standards—UN number, hazard label, and certified personnel all come standard. Environmental impact deserves attention: spills quickly dissolve, so containment, neutralization, and waste observation plans cut the risk of entry into water tables. Responsible facilities train all staff, prepare for emergencies, and tightly track inventory to avoid accidental release or misuse.
Global demand for pure guanidine hydrochloride rises with pharmaceutical and agrochemical expansion, yet supply chains rely on reliable, high-quality raw materials—usoften guanidine carbonate or cyanamide. Quality often hinges on feedstock purity and process control—scrutiny increases during regulatory review for drug synthesis. Some plants invest in green chemistry principles, seeking cleaner synthesis routes and better wastewater management to reduce hazardous byproducts. Market stability connects directly to responsible management. Building partnerships with vetted producers, running routine quality controls, and investing in high-efficiency purification units builds trust with clients and meets regulatory scrutiny. Emphasis on worker training, traceability, and environmental stewardship ensures future operations protect people and planet, despite growing throughput and tighter global oversight.
