Guanidine Hydrochloride stands out as a strong organic base, often seen in its pure form as a colorless, odorless crystalline solid. With the chemical formula CH6N3Cl and a molecular weight of about 95.53 g/mol, this compound holds a key role across many branches of science and industry. Its crystalline form can break down under high temperatures, releasing toxic gases like nitrogen oxides and hydrogen chloride. With a melting point near 181–183°C, Guanidine Hydrochloride dissolves well in water and alcohol, which makes it handy for many chemical and biological applications. The material’s density measures about 1.354 g/cm³ in solid form.
This chemical’s structure features the guanidinium cation (C(NH2)3+) paired with a chloride anion (Cl-). It most often appears as white flakes, crystals, powders, or sometimes in fine pearls. Sometimes, manufacturers prepare it as a solution for easy integration into processes like protein denaturation or cell lysis. In solid form, it flows easily enough and handles well in both manual and automated environments. HS Code for Guanidine Hydrochloride sits at 29252900, which matters for international trade and customs.
Strong chaotropic ability sets Guanidine Hydrochloride apart from milder agents. Its main claim to fame in the life sciences comes from its talent for unfolding proteins and disrupting non-covalent interactions. In water, this chemical dissolves at concentrations upwards of 6 mol/L, making it the top pick for extraction protocols in molecular biology. High solubility, broad compatibility, and easy storage add to its appeal. It stands stable under dry conditions in sealed packaging, away from moisture, acids, and oxidizers. Its chemical raw material status often means bulk shipments in drums lined to prevent leaks or contamination.
Manufacturers turn to Guanidine Hydrochloride as a trusted material in protein sequencing, RNA isolation, and pharmaceutical synthesis. It strips away proteins' secondary and tertiary structures, leaving only the primary sequence intact, essential for detailed structure–function studies. Users sometimes use it as an intermediate in creating medicines or resins, showing how versatile this chemical material can be. Although water solutions can be measured in liters, solid formats such as flakes, granules, or fine crystals get weighed for mixing and storage. Each format suits a different step in research or manufacturing, all delivering consistent molecular properties. Researchers value its purity—commonly 99% or above for biochemical use—which ensures no background interference during sensitive experiments.
Handling Guanidine Hydrochloride requires proper safety steps. This material causes irritation to eyes, skin, and the respiratory tract. Direct contact can lead to harmful effects, so anyone working with it should wear gloves, goggles, and lab coats. Using chemical fume hoods and proper ventilation cuts the risk of inhaling dust or vapors. Spills call for swift cleanup using absorbent materials, followed by thorough washing of the area. Long exposures, especially in unventilated spaces, may affect the nervous system. Due to its hazard profile, labeling of storage containers and adherence to chemical safety protocols in all environments—lab, warehouse, transit—remain crucial.
It takes experience to know how chemical hazards translate into daily risks. Having worked alongside others who handle Guanidine Hydrochloride means relying on strong teamwork and respect for chemical safety. The bottle’s label and Safety Data Sheet aren’t busywork—they’re shields against accidental overdosing, spills, or confusion. In any situation, material compatibility matters: storing this chemical near oxidizers or acids invites trouble, which some operators learn the hard way. Regulations require detailed traceability and clear record-keeping, which simplifies recalls or audits and protects both workers and downstream users.
The main challenge with chemicals like Guanidine Hydrochloride is balancing efficiency with safety, especially during scale-up or new applications. My experience in research settings taught me that clear labeling, frequent retraining, and updated procedures lower accident rates and preserve lab morale. Automation of weighing and solution prep for bulk users can keep exposure low and consistency high. For small-scale researchers or teaching labs, providing ready-made solutions, rather than requiring students or staff to mix powders, prevents mishandling and reduces waste. Waste management—another constant worry—improves with waste labeling, on-site neutralization, and trained personnel familiar with local disposal regulations.
Guanidine Hydrochloride remains a cornerstone raw material in both science and industry. Key identifiers include a specific density of about 1.354 g/cm³, molecular formula CH6N3Cl, and solid forms ranging from flakes to pearls. Its hazardous and harmful potential means that rigorous safety steps, material compatibility, and ongoing training take priority. Responsible use stretches from secure storage, through careful weighing, to smart waste management, ensuring the benefits of this powerful tool do not bring unintended risks.
