(2S-Cis)-(Diphenylmethyl)-N-(Phenylmethyl)-1-Azabicyclo[2.2.2]Octan-3-Amine (1-R Camphor-10-Sulfonate) comes from a family of complex organic molecules shaped by rigorous stereo-chemical design. Chemists have engineered its structure to feature a rigid azabicyclo[2.2.2]octane core. Attached to this core, multiple phenyl groups and a camphor-10-sulfonate branch fill out a dense lattice of rings and side chains. Such a structure attracts interest for its role in synthetic chemistry, both as an intermediate and as part of various enantioselective synthesis routes. Looking at the molecular organization, the compound has a molecular formula designed to balance bulk and reactivity. The arrangement of bulky diphenylmethyl and phenylmethyl groups means the molecule’s three-dimensional profile impacts its reactivity and separations more than simple numbers could show. Often found as a crystalline solid, sometimes presenting as flakes or powder, the substance handles like other organics but stands out with higher density and solubility quirks due to its bulky, asymmetrical form.
Straight from the bottle, (2S-Cis)-(Diphenylmethyl)-N-(Phenylmethyl)-1-Azabicyclo[2.2.2]Octan-3-Amine (1-R Camphor-10-Sulfonate) tackles the bench as a solid. The compound typically appears white or off-white, a reminder that high purity plays a big role in performance, especially for synthesis. With a melting range echoing its intricate stereo-chemistry, the product may melt not as a sharp single point, but instead gradually, sometimes highlighting batch-to-batch variation. Density sits high, above many simple amines, an effect of all those interlocking rings and aromatic rings. The solid can show up as rough crystals, coarse powder, slabby plates, or sometimes even pearly beads if recrystallized a certain way. Solubility reveals more: in polar solvents like water, you may spot sluggish dissolution, but alcohols and certain ethers open up pathways for fast solution mixing. Special handling comes into play since physical state can affect measuring—sticky flakes pile up differently from free-pouring powder or neat crystals.
Every time a chemist sketches this molecule, the rings dominate the drawing. The core bicyclo[2.2.2]octane pushes rigidity, holding three bridges in a locked conformation. The camphor sulfonate patch, sticking out at position 1R, offers not just acid-base behavior but also chirality. Those phenyl and diphenyl side groups bring electron clouds, shifting how the molecule interacts in organic transformations. Functional as a building block, the amine group pulls in protons and connects up with other reagents. In labs, it sometimes acts as a resolving agent, helping split pairs of enantiomers—a job that matters for everyone who cares about biological activity or pharmaceuticals. The compound avoids oxidation under mild air contact, but strong acids and bases might tweak it if left unchecked. Chemists often think of it as a safe intermediate for steps where C-N bond stability counts.
Pure lots sit at over 98% assay by NMR, IR, or HPLC, with little water or residual solvent. Labs check melting point, range, and clarity. Moisture can creep in, so storage in sealed vessels pays off. The global trade scene recognizes the compound under the Harmonized System Code for organic base salts, often falling near 2921.49. As an N-alkylated bicyclic amine with sulfonate salt, it sits among organo-nitrogen chemicals that ship under safe storage and declaration practices. Safety data sheets roll out with every delivery, especially since international regulations watch closely for intermediates with medicinal or stimulant potential.
Hard to overstate the importance of density and bulk handling. This molecule’s density comes in higher than the average, a marker of all those heavy rings and extra atoms crammed together. More weight per spoonful means weighing by volume turns unreliable—best practice always calls for a balance for quantifying. Dissolution follows the rules of hydrophobic aromatics and charged sulfonate ends: pretty good in alcohol, tough in plain water unless heat or mixed solvents help. Solution prep asks for patient stirring, sometimes ultrasound. The compound holds up to light handling, but grinding can generate dust, so respirators or tight lids keep things safe. Crystals can attract static due to surface area; labs using it for precise dose regimes often ground the equipment or damp down with inert gases.
Modern labs ask tough safety questions, as novel organics sometimes hide surprises. For (2S-Cis)-(Diphenylmethyl)-N-(Phenylmethyl)-1-Azabicyclo[2.2.2]Octan-3-Amine (1-R Camphor-10-Sulfonate), inhalation of dust or powder brings mild to moderate irritation. Eye splash, always a risk with white solids, means quick water flush. Limited skin absorption leaves most exposures on the mild side, but chemical gloves and goggles keep the odds safer. As for toxicity, high doses could cause nervous system effects—headaches or dizziness if ingested or inhaled in quantity. Waste management does not skip steps: organics like this go in lined, labeled containers, and labs treat contaminated solutions as hazardous until cleared by a chemist or environmental specialist. The compound does not create persistent environmental dangers under standard waste treatments.
Each package that ships carries a precise molecular formula unique to this molecule, marking it as a single, well-defined entity among bicyclic amines. Structural diagrams show a network of fused rings capped with multiple aromatic groups and a camphor-derived sulfonate, making the substance distinct from other ring systems in organic chemistry. Spectroscopy data—think NMR for hydrogen and carbon, IR for fingerprinting—traces every major side group directly. The specs include purity, residual solvent thresholds, and limits for related byproducts. Every batch includes a certificate of analysis so customers and labs know what compounds ride shotgun alongside the main event. Storing at room temperature, away from oxidizers and acids, prevents slow degradation and keeps reactivity in check until the next reaction run.
Tracing the raw materials stretches back to complex carbocyclic precursors and chiral auxiliaries. Production leans on skilled organic synthesis, starting with camphor sulfonic acid and specialty alkylating agents. The core azabicyloctane can spring from multistep coupling, involving protected amines and phenyl halides. Quality depends on every ingredient; even small impurities early in the process snowball through multiple chemical steps. Producers spend a lot on analytical control—if the base camphor sulfonate fails, the whole batch may fall short on optical purity or leave behind hard-to-separate regents. Experienced chemists find the origins important, because knowing the feedstock helps predict both reactivity in the lab and safety during scale-up.
In hands-on handling, this compound gives a range of textures and shapes. As a solid, it piles up like white flour or sand, yet feels heavier scoop by scoop. Some lots, especially higher purity, shift toward shiny crystals—showcasing the power of slow recrystallization. Flakes or platelets break apart fast, so some users prefer powder for blending and fast solubility, even if it leads to more dust. Pearl forms, less common but striking, hint at tailored manufacturing—spheres cut down on static charge and pour with stability, a small feature but a big deal for those running automated lines. This chemical never comes as a regular liquid at room temperature; all storage and weighing must factor in its solid-state quirks.
I’ve spent hours trying to coax recalcitrant organic solids into solution, and this molecule behaves true to form. Heat, mixed solvents, or pre-wetted glassware make a difference, especially when working with crystalline grades. Regulatory hurdles come up if the compound ranks as a controlled intermediate, so labs keep paperwork airtight. For storage, desiccators and tight seals help, keeping density stable and moisture off. Training staff to handle powders, not just scoop or pour, but to measure with care, goes a long way toward safety and quality. Better packaging—air- and moisture-tight, with built-in antistatic—makes a surprising difference for batch-to-batch consistency. Sharing lessons learned, including small tips for safe cleanup or waste collection, matters just as much as the pure science. If regulatory updates roll in, companies should stay ahead with upgraded safety data sheets and updated transport practices, keeping the compound as safe and efficient to use as possible through the whole lifecycle.
