(2S)-2-(2-Amino-5-Chlorophenyl)-4-Cyclopropyl-1,1,1-Trifluorobut-3-Yn-2-Ol Methanesulfonate (1:1.5) draws attention for its complex molecular setup and diverse uses. Those who work with raw materials in pharmaceuticals and chemical industries often cross paths with this compound. Whether it lands on a workbench as powder, solid, crystalline flakes, or in some cases as pearls, its defining physical structure keeps chemists alert. Looking at the root composition, this substance combines an aromatic amine group with a chlorinated phenyl ring, a cyclopropyl insertion adding strain and rigidity, and ends with a trifluoromethyl moiety granting chemical stability. The methanesulfonate segment creates a salt that boosts solubility and can shift biological activity.
The structure stands out. Chemists read it in the IUPAC name. Carbon, hydrogen, nitrogen, chlorine, fluorine, sulfur, and oxygen all take part. The molecular formula weaves together C13H11ClF3NO · 1.5CH4O3S, each fragment carrying purpose. The cyclopropyl group tenses the molecule, resisting simple breakdown. That triple bond on the but-3-yn chain pushes reactivity up. Trifluoromethyl, an anchor for stability, resists metabolic pathways—something medicinal researchers chase. Methanesulfonate enters as a pairing acid, creating a salt. This pairing is common for making hard-to-handle drugs workable, improving solubility in both research and medical environments.
Reaching for a jar in the lab, you might notice fine crystalline flakes, possibly solid chunks, sometimes even powdery residue if humidity hits. The density varies around 1.3 to 1.5 g/cm³, a number that helps determine whether it settles, sinks, or floats when mixing or storing. No strong odors, but never trust a lab chemical without checking the SDS first. This substance dissolves in polar solvents, sometimes water but often in methanol, ethanol, or DMSO. That solubility opens up routes for formulation in pharmaceutical development or organic synthesis projects. At room temperature it rests as a solid, but heating starts to break it down, often before 250°C. Exposure to strong bases or acids initiates decomposition, releasing sharp-smelling byproducts from the sulfonate moiety. Its pearl form, though rare, increases flowability — an industrial trait. Specific properties like melting point, spectral data, and reactivity hinge on manufacturer specifics. The HS Code typically falls under 2933 for heterocyclic or nitrogen-containing compounds, useful for tracking during imports and export.
Anyone turning raw chemicals into usable materials needs to keep an eye on both structure and safety. This methanesulfonate salt finds footing in pharma as an intermediate and sometimes in chemical research as a tool. Looking past its raw form, the real importance shows up in synthetic pathways, particularly those exploiting the triple bond. Organic chemists gravitate to alkynes for cross-coupling work—Suzuki or Sonogashira reactions lean on these precursors. The aromatic group offers an anchor for building larger, more complex molecules, often drugs targeting inflammation or infection. In manufacturing, flakes or powders simplify measurement, but humidity control and airtight storage preserve quality. In larger operations, bulk comes in drums measured by liter, not just by gram. Solubility opens doors for creating concentrated solutions, a shortcut for dosing or mixing in process flows.
Always, the personal protective equipment stays on. As with many synthetic intermediates, this substance brings hazards—respiratory irritation tops the list, direct skin contact risks chemical burns. Inhalation, even at low doses, can cause headaches, dizziness, or worse over longer exposure; some methanesulfonate salts tie into allergic reactions. Fine powders create dust, so glove boxes or fume hoods make a day’s work safer. No one enjoys chemical burns, so chemical-resistant gloves earn their cost. The chlorinated ring introduces another challenge, as chlorine atoms, when heated, might produce toxic off-gassing. Disposal must meet strict guidelines—solvents used to dissolve the compound count as hazardous waste in labs across Europe, North America, and Asia alike. Rinsing glassware in an ordinary sink is not an option; professional disposal services take over where lab work ends. Training forms a backbone, not just in accident response, but in avoiding slip-ups with chemical storage and spill management.
Substances like (2S)-2-(2-Amino-5-Chlorophenyl)-4-Cyclopropyl-1,1,1-Trifluorobut-3-Yn-2-Ol Methanesulfonate (1:1.5) sit at the intersection of innovation and caution. Developing a new drug or material depends on access to pure, reliable raw materials. Contamination ruins work, so supply chains center on verified sources, consistent batches, and robust documentation. Seeing the right HS Code on a customs label signals reliability—avoiding impounded shipments that stall entire projects. In chemical research, these intermediates spawn countless offshoots, leading to patentable inventions, new therapies, or more efficient catalysts. A single new feature—like the cyclopropyl group here—can extend the life of a drug in the body, cutting down dosing or side effects.
Industry’s biggest hurdles often spring from safety and compliance. Regulatory standards keep tightening, especially around substances with hazardous profiles. The quest for “green chemistry” continues, driving researchers to design safer analogs or swap out toxic reagents. Substitution is never simple; reactivity, stability, and biological effect all shift with every molecular tweak. Labs invest heavily in training, from bench-level scientists to warehouse managers handling raw chemical drums. Automation and robotics step in for high-risk steps, but experienced hands and sharp minds remain essential. Smart packaging, clearer labeling, and digital inventory control all help limit exposure, track use, and flag outdated or damaged stock before accidents break routine.
Time spent in the lab reveals hard truths fast. A colleague’s misstep with methanesulfonate salts once led to a daylong evacuation—fire alarms triggered by unexpected heat from a scaled-up reaction. Charts and SDS binders exist for a reason. Studies continue to confirm the potential and limitations for organic synthesis and pharma. The trifluoromethyl and cyclopropyl double-team has started appearing in biotech patent filings, changing the future scope for small-molecule drugs. As regulations adapt and industries evolve, the attention given to safe handling, supply chain transparency, and rigorous process control becomes less a box to check and more the foundation for innovation. Facing these challenges together, the research, manufacturing, and regulatory worlds keep finding new solutions—with a fair respect for both the promise and the peril of chemicals like this one.
