The name 2-Butyl-3-(4-Chlorobenzyl)-1,3-Diazaspiro[4.4]Non-1-En-4-One stands out in any chemical catalog, both for its complexity and the challenges it brings to practical use. This compound forms a unique bond between a diazaspiro framework and a chlorinated benzyl group. Solid at room temperature, it usually appears as pale crystals or off-white powder, rarely showing up in a granular or liquid state. Many researchers and professionals encounter it in the laboratory, sometimes handling it as flakes for easier measurement, although larger batches lean toward powder or compact solid. Its density, hovering around the mid-range for organic spiro compounds, gives it a profile that’s easy to store without special bulk management.
HS Code classification for chemicals like this often falls under 2933, which covers heterocyclic compounds with nitrogen hetero-atom(s) only. These numbers might not seem important until customs stops a shipment. The dense documentation process forces everyone involved—manufacturers, importers, labs—to double-check against listing errors or bottle mislabeling. In terms of the molecular formula, C19H23ClN2O sums up the actual atoms packed into each molecule, revealing a moderate polarity and substantial hydrophobic surface. That formula, more than just a sequence, signals a degree of chemical toughness. Its raw material origins track back to aromatic amines, cycloalkanones, and butyl halides, each pushing up production costs and potential hazards.
Most chemists will note the spiro ring system in this molecule, a chemical structure appreciated for squeezing in rigidity and conformational control. Adding a 4-chlorobenzyl arm transforms the core properties. The chlorine atom, more than a token halogen, introduces both reactivity and a measure of environmental concern. Stability under moderate conditions comes as a relief for many industries, since instabilities often mean dangerous breakdown products. Heat can prompt mild decomposition, but nothing like the runaway reactions seen in peroxides or azides. Handling as solid or crystalline powder rarely creates dust, so risks remain lower during common transfers, but this does not mean it belongs in an open workspace. Every pharmaceutical professional I know keeps a supply of fitted gloves and a fume hood for handling, since airborne dust from spiro compounds, even in trace amounts, may irritate eyes and respiratory passages.
Hard data on melting point puts this compound in the 90–120°C range, a span that reflects the balance between bulk and molecular packing. Such detail matters for scale-up; plant operators adjust heating profiles to avoid clumping or uneven melting. Solubility depends both on solvents used and on the fine structure of the molecule. It shows decent solubility in polar aprotic solvents—dimethylformamide works well—while water resistance prevents unintentional leaching during handling or waste removal. Recrystallization shapes it into pure solid, and even at scale, no one wants unknown side-products falling through the cracks.
This acid brings a rigid norbornanone backbone, interrupted by a methanesulfonic acid tail. Laboratory personnel find it mostly in sharp-edged crystals, sometimes compacted into pearls for easier handling at scale. Its density reads higher than typical liquid acids, which gives it some heft in the container. Not something that splashes easily or evaporates on the benchtop, but its acidity remains strong enough to etch glassware over time. Chemical formula C10H14O4S packs the carbon scaffold and sulfur-based acid into a compact unit. That sulfur, usually sticking out in the form of a sulfonic group, signals both strong ionization in solution and a sharp, pungent odor familiar to anyone who’s ever worked with methanesulfonic derivatives.
HS Code for this material traces to 2904—sulfonic acids—reflecting regulatory focus on acidity and environmental discharge. Import paperwork, hazard declarations, and shipping documents all require careful handling of these numbers. As a raw material, it’s built from cyclohexanone and dimethylsulfonic reagents, and every batch should include full spectral verification (usually NMR and HPLC) to keep quality high and impurities low. This detail matters not just in finished goods but in the waste stream, as disposal regulations target both the parent chemical and any breakdown products. Its melting point varies from 110°C to 130°C, depending on water content and purity. Pure forms appear crystalline, and powdery forms trade a bit of convenience for extra risk of inhalation. Liquid states arise only after heating, rarely seen outside of intentional production runs.
Safety stands as the central concern for both chemicals. Direct skin contact causes irritation; worse, accidental inhalation of fine powder leads to respiratory distress. Eye protection, gloves, and masks should be part of every procedure—it only takes minor negligence for a routine task to end badly. Folk wisdom in chemical safety, learned from painful experience, always puts a premium on double-checking labels and never skipping personal protective gear. Both materials rate as hazardous under GHS and European standards, often labeled as harmful on shipping manifests. Disposal after use doesn’t end with pouring down the drain; waste streams require neutralization and collection under licensed protocols, since surface water contamination sparks audits and, in some places, heavy fines.
Both chemicals qualify as raw materials in pharmaceutical or specialty chemical manufacture. Their hazards highlight a crossroad for facility design. Separate, dedicated lines for toxic intermediates keep risk low while helping avoid unexpected cross-reactions. Accidental mixing of solvent streams or sloppiness with labeling causes emergency shutdowns, none of which endear a chemist to their site supervisor. Training, at least in reputable labs and plants, includes run-throughs of safety data sheets, mock spill drills, and periodic audits by outside consultants. All these measures serve to catch problems before a production run turns into a hazard zone, always better than making headlines for the wrong reasons.
Production runs involving 2-Butyl-3-(4-Chlorobenzyl)-1,3-Diazaspiro[4.4]Non-1-En-4-One or its sulfonic acid counterpart often suffer from scaling headaches and waste stream management. Production at pilot scale reveals inefficiencies missed in benchtop batches—heat transfer turns less uniform, crystallization comes out spotty, and solvent recovery systems clog with minor intermediates. Many operators share stories of lost product in the filter press or reactor cleanup, a small error that scales into expensive losses. Maintenance on gear handling these corrosive or hazardous intermediates counts as regular as shift meetings, since small gasket leaks or valve failures create a safety nightmare.
Solutions require both technology upgrades and people-focused change. Modern containment systems—closed transfer, automated dosing, real-time air monitoring—reduce the chance of accidental exposure. Older plants that invest in sensor upgrades and improved air handling usually report fewer incidents. Staff education also makes the difference. A knowledgeable team spots unsafe practices early, and an alert environment discourages risky shortcuts. Companies who put real energy into training win fewer fines, lower insurance bills, and, not least, healthier workers who build a reputation for reliability. Documentation, notoriously tedious, protects everyone from paperwork errors leading to surprise investigations or customs blocks. Every detail written, tracked, verified keeps complex productions moving and guardrails firmly in place.
