Product Name: Trimethylsilyl Trifluoromethanesulphonate
Synonyms: TMSOTf, Trimethylsilyl Triflate
Chemical Formula: C4H9F3O3SSi
CAS Number: 27607-77-8
Recommended Use: Laboratory reagent, chemical synthesis
Supplier Details: Contact information of manufacturer or distributor
Emergency Telephone: Emergency contact number available on supplier label
GHS Classification: Skin Corrosion/Irritation Category 1B, Serious Eye Damage Category 1
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, causes serious eye damage
Pictograms: Corrosive (GHS05)
Precautionary Statements: Do not breathe dust, fume, gas, mist, vapors, spray. Wear protective gloves, protective clothing, eye protection, face protection. Wash hands thoroughly after handling. In case of inadequate ventilation, wear respiratory protection.
Chemical Name: Trimethylsilyl Trifluoromethanesulphonate
CAS Number: 27607-77-8
Concentration: 98–100%
Impurities: No significant component affecting hazard classification
Molecular Weight: 222.26 g/mol
General Advice: Move away from source of exposure, seek medical attention immediately. Remove contaminated clothing.
Inhalation: Move person to fresh air. Keep in position comfortable for breathing. Seek medical attention.
Skin Contact: Wash off with plenty of water for at least 15 minutes. Remove contaminated clothing. Seek urgent medical advice.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if easy to do. Continue rinsing. Get immediate medical attention.
Ingestion: Rinse mouth. Do not induce vomiting. Seek immediate medical attention.
Suitable Extinguishing Media: Dry chemical powder, alcohol-resistant foam, carbon dioxide. Avoid using water directly on product due to reactivity.
Specific Hazards: Vapors may form explosive mixtures with air. Thermal decomposition may produce toxic gases such as hydrogen fluoride, silicon oxides, and sulfur oxides.
Protective Equipment: Wear self-contained breathing apparatus. Wear chemical protective suit.
Special Procedures: Cool containers exposed to fire with water spray from distance. Avoid breathing vapors or combustion products.
Personal Protection: Wear chemical splash goggles, protective gloves, chemical-resistant clothing. Ensure adequate ventilation.
Environmental Precautions: Prevent entry into soil, waterways, drains, or sewers.
Cleanup Methods: Collect spilled liquid in inert absorbent (sand or vermiculite). Avoid runoff. Transfer to a container for disposal according to local regulations. Wash affected area with copious water.
Other Considerations: Remove sources of ignition. Ventilate area. Use non-sparking tools.
Handling: Avoid contact with skin, eyes, and clothing. Use only with adequate ventilation. Avoid generating vapors or aerosols. Wash hands thoroughly after handling. Do not eat, drink, or smoke when handling chemical.
Storage: Store in cool, dry, well-ventilated area away from incompatible materials like water, strong bases, and oxidizers. Keep container tightly closed. Protect from moisture. Use corrosion-resistant storage containers.
Engineering Controls: Use local exhaust ventilation or chemical fume hood to minimize exposure. Maintain adequate air exchange.
Eye Protection: Chemical safety goggles and face shield.
Skin Protection: Chemical-resistant gloves (such as butyl rubber), laboratory coat, apron.
Respiratory Protection: Use NIOSH/MSHA approved respirator if exposure limits are exceeded or in confined areas.
Hygiene Measures: Wash hands thoroughly before breaks and after handling. Remove contaminated clothing before entering eating areas.
Appearance: Colorless liquid
Odor: Pungent, irritating
Odor Threshold: Not available
pH: Strongly acidic (hydrolyzes)
Melting Point/Freezing Point: -35°C
Boiling Point: 108°C at 760 mmHg
Flash Point: 61°C (closed cup)
Evaporation Rate: Not available
Flammability: Not highly flammable
Explosion Limits: Not available
Vapor Pressure: 19 hPa at 20°C
Vapor Density: >1 (air = 1)
Relative Density: 1.33 g/cm³ at 25°C
Solubility: Reacts with water
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not available
Decomposition Temperature: Not available
Viscosity: Not available
Chemical Stability: Decomposes slowly in presence of moisture. Stable under dry, inert conditions.
Possibility of Hazardous Reactions: Violent reaction with water, strong bases. Generates highly corrosive and toxic gases.
Conditions to Avoid: Exposure to moisture, heat, open flames, sources of ignition.
Incompatible Materials: Water, strong bases, oxidizing agents, alcohols, amines.
Hazardous Decomposition Products: Hydrogen fluoride, sulfur oxides, silicon oxides, trifluoromethanesulfonic acid.
Acute Toxicity: Harmful if swallowed, inhaled, or in contact with skin. Reliable quantitative values not widely published.
Skin Corrosion/Irritation: Causes severe burns, may cause ulceration.
Serious Eye Damage/Irritation: Risk of permanent damage and blindness.
Respiratory Sensitization: May cause respiratory tract irritation, coughing, sore throat.
Chronic Effects: Prolonged exposure may damage mucous membrane, tissues, and respiratory system.
Carcinogenicity: No data indicating carcinogenic potential.
Mutagenicity: No data indicating genotoxicity.
Reproductive Toxicity: No data indicating reproductive effects.
Routes of Exposure: Ingestion, inhalation, skin and eye contact.
Ecotoxicity: Toxic to aquatic life due to acidity and persistence of breakdown products. Exact quantitative data not available.
Persistence and Degradability: Expected to be persistent because of slow hydrolysis and stability in the absence of water.
Bioaccumulative Potential: No significant data.
Mobility in Soil: May leach through soil before hydrolysis.
Other Adverse Effects: Reacts with water to generate corrosive acid with environmental risks.
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations. Do not release into environment.
Product Waste: Small amounts can be neutralized by slow addition to a suitable acid-neutralizing agent under controlled conditions. Avoid fumes.
Contaminated Packaging: Rinse empty containers with neutralizing agent, then dispose of as hazardous waste.
Special Instructions: Seek guidance from local hazardous waste disposal authority. Retain chemicals in original containers for disposal.
UN Number: UN 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains Trimethylsilyl Trifluoromethanesulphonate)
Transport Hazard Class: 8
Packing Group: II
Label: Corrosive
Environmental Hazards: Not classified as a marine pollutant
Special Precautions: Transport only in permitted containers. Secure containers and avoid mechanical shocks.
OSHA: Hazardous chemical as defined by the OSHA Hazard Communication Standard.
TSCA: Listed on Toxic Substances Control Act inventory.
REACH: Registered or notified according to European regulations as needed.
SARA Title III: Not specifically listed under Sections 302, 304, or 313.
California Proposition 65: Not listed.
Other Regulations: Follow all applicable workplace safety, health, and environmental laws. Local, national, and international regulations may apply based on location and intended use.
