Product Name: Trifluoromethanesulphonic Anhydride
CAS Number: 358-23-6
Synonyms: Triflic Anhydride, Trifluoromethanesulfonic anhydride
Chemical Formula: C2F6O5S2
Recommended Use: Laboratory chemicals, industrial manufacturing, chemical synthesis applications
Supplier Details: Chemical manufacturer or distributor contact information should be listed on container label
Emergency Telephone: Available through regional poison control and manufacturer emergency lines
GHS Classification: Corrosive to metals (Category 1), Skin Corrosion/Irritation (Category 1A), Serious Eye Damage/Irritation (Category 1), Acute Toxicity – Oral (Category 4)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, may cause respiratory irritation and serious damage to mucous membranes, harmful if swallowed, reacts violently with water releasing heat and toxic fumes
Pictograms: Corrosive, Exclamation mark
Precautionary Statements: Avoid contact with eyes, skin, and clothing, do not breathe fumes or vapors, use only outdoors or in well-ventilated areas, keep container tightly closed, store locked up, wash thoroughly after handling
Chemical Name: Trifluoromethanesulphonic Anhydride
Concentration: > 98%
CAS Number: 358-23-6
Impurities: Typically contains trace moisture, hydrolyzed derivatives may develop on exposure to humidity
Other Components: No significant non-classified substances present
Inhalation: Move person to fresh air, keep at rest in position comfortable for breathing, seek immediate medical attention, administer oxygen if breathing is difficult
Eye Contact: Immediately flush with plenty of water for at least 15 minutes, remove contact lenses if present and easy, continue rinsing, seek urgent ophthalmological evaluation
Skin Contact: Remove contaminated clothing and shoes, rinse affected skin with plenty of water for at least 15 minutes, seek medical assistance for persistent irritation or burns
Ingestion: Rinse mouth, do not induce vomiting, never give anything by mouth to an unconscious person, seek urgent medical assistance
Notes to Physician: Treat symptomatically, monitor for signs of respiratory distress, intensive supportive care may be needed for chemical burns and pulmonary irritation
Suitable Extinguishing Media: Use dry chemical, CO2, or foam; water may be ineffective or dangerous due to exothermic hydrolysis
Specific Hazards Arising from the Chemical: Releases toxic gases like hydrogen fluoride, sulfur oxides, and trifluoromethanesulphonic acid on decomposition, reacts with water to form acids and heat
Special Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective chemical-resistant clothing
Firefighting Instructions: Isolate area, cool containers with water spray from a distance to prevent pressure buildup, prevent runoff from entering drains or watercourses
Personal Precautions: Wear full chemical protective equipment including splash goggles, gloves, face shield, and an acid-resistant suit, avoid all direct contact
Environmental Precautions: Prevent further leakage or spillage if safe to do so, do not allow material to enter sewers or waterways, notify environmental authorities if contamination occurs
Containment and Clean-up Methods: Absorb with inert dry material such as sand, diatomaceous earth, or vermiculite, vacuum or sweep up residue, place in suitable container for hazardous waste disposal, ventilate area thoroughly, neutralize acid residue with lime or sodium bicarbonate if safe
Safe Handling: Use only in chemical fume hood, avoid release to the environment, avoid direct physical contact, open only in well-ventilated areas, do not mix with water or wet compounds, never add water to this chemical
Storage Conditions: Store tightly closed in cool, dry, and well-ventilated area designed for corrosive acids, segregate from oxidizing agents, bases, alcohols, and water-containing substances, keep container out of direct sunlight, label container clearly and keep it secured
Incompatible Materials: Water, strong bases, strong oxidizers, alcohols, amines
Occupational Exposure Limits: No established limit for this specific compound; handle as a strong acid and respiratory sensitizer
Engineering Controls: Maintain adequate ventilation, use chemical fume hood, provide eyewash stations and safety showers nearby
Personal Protective Equipment: Acid-resistant gloves (nitrile, neoprene), lab coat, chemically splash-resistant goggles, face shield, chemical-resistant apron, appropriate respiratory protection if airborne concentrations are high or in case of spill or accidental release
Hygiene Measures: Wash hands before breaks and after work, do not eat or drink during use, launder contaminated clothing before reuse
Appearance: Clear, colorless to slightly yellow liquid
Odor: Strong, irritating, characteristic acrid odor
pH: Acidic (after contact with water)
Melting Point/Freezing Point: -80 °C
Boiling Point: 81 °C at 760 mmHg
Flash Point: Not applicable (non-flammable)
Vapor Pressure: 32 mmHg at 20 °C
Vapor Density: Heavier than air
Solubility in Water: Violent hydrolysis with heat and formation of acid
Density: 1.67 g/cm3 at 20 °C
Partition Coefficient (log Kow): Not determined
Evaporation Rate: Not determined, but expect similar to other volatile acids
Decomposition Temperature: Above 100 °C, decomposes generating toxic gases
Chemical Stability: Stable under dry, cool, inert atmosphere; rapidly decomposes in presence of moisture
Reactive Hazards: Violently reacts with water, strong bases, strong oxidizers, alcohols, amines
Conditions to Avoid: Exposure to moisture, humid air, elevated temperatures, incompatible chemicals
Hazardous Decomposition: Produces toxic and corrosive fumes of trifluoromethanesulphonic acid, sulfur oxides, fluorinated compounds
Polymerization: Not expected to occur under recommended storage and handling conditions
Acute Toxicity: Harmful if swallowed (LD50 rat: estimated < 300 mg/kg), inhalation and skin contact cause severe burns
Skin Corrosion/Irritation: Rapidly destructive to tissue, may cause blackening and necrosis on contact
Serious Eye Damage/Irritation: Exposure results in irreversible eye damage including blindness
Respiratory Effects: Causes severe irritation to the respiratory tract, pulmonary edema may follow substantial exposures, coughing and choking common with inhalation
Sensitization: No data, avoid repeated or prolonged exposure
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, ACGIH, or OSHA
Mutagenicity: No significant evidence reported
Reproductive Toxicity: No specific data available
Long-term Effects: Scarring, chronic respiratory illness possible after acute exposure, no controlled human studies
Aquatic Toxicity: Highly toxic to aquatic life due to strong acidity and release of fluorinated acids, may cause fish kills and ecosystem harm if released
Mobility in Soil: Expected to rapidly hydrolyze to trifluoromethanesulphonic acid, which is mobile and leaches in soil
Persistence and Degradability: Will not persist as anhydride, decomposes to sulfonic acid, resists further biodegradation
Bioaccumulation: Potential for bioaccumulation seems low, but acidification harms aquatic species
Other Adverse Effects: Strong acidification of soil and water, disrupts biological denitrification and natural pH balance
Waste Disposal: Collect residues in approved tightly closed acid-resistant chemical waste containers, neutralize cautiously with alkaline material before disposal if allowed by local regulations, do not allow untreated material to reach sewer, surface water, or soil
Safe Handling for Disposal: Neutralization and controlled hydrolysis by trained personnel using adequate protective equipment, follow all federal, state, and local environmental control guidelines
Contaminated Packaging: Rinse empty containers cautiously, destroy according to hazardous waste regulations, do not reuse containers for other purposes
UN Number: UN 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains Trifluoromethanesulphonic Anhydride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Transport Labels: Corrosive symbol, keep away from moisture and incompatible chemicals during shipping
Special Precautions: Store securely during transit, keep upright, consult DOT, ADR, IMDG, and IATA guidance for safe shipping
Marine Pollutant: Not classified as marine pollutant, but acute hazard to aquatic life if spilled
OSHA: Classified as hazardous, covered under Hazard Communication Standard
TSCA Status: Listed on United States TSCA Inventory
REACH Registration: Subject to European REACH regulations for import and use
SARA Title III (Sections 302/304/311/312/313): Reportable under acute health hazard category, no threshold planning quantity established
California Prop 65: Not listed
Other State Regulations: Subject to state right-to-know regulations for hazardous substances
Canadian DSL/NDSL: Listed
WHMIS Classification: D1B (Toxic), E (Corrosive)
