Product Name: Trans-(4-(Methylamino)Cyclohexyl)Methanesulfonic Acid
Common Names: Methylamino Cyclohexyl Methanesulfonic Acid
CAS Number: 1679332-73-6
Recommended Use: Laboratory research, chemical synthesis, pharmaceutical intermediate
Restrictions: Not intended for human or veterinary drug use, food additive, or household usage
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Classification: Acute Toxicity (Oral, Dermal), Irritant (Skin, Eyes), Specific Target Organ Toxicity
Signal Word: Danger
Hazard Statements: Causes skin and eye irritation; may cause respiratory irritation if dust or solution becomes airborne; toxic if swallowed or absorbed through skin
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid ingestion and inhalation; avoid contact with skin and eyes; wash thoroughly after handling; use only outdoors or in a well-ventilated area
Other Hazards: Reacts with strong oxidizers; may decompose under heating, producing toxic fumes
Chemical Identity: Trans-(4-(Methylamino)Cyclohexyl)Methanesulfonic Acid
Chemical Formula: C8H17NO3S
Molecular Weight: 207.29 g/mol
Purity: >99% (if specified by supplier)
Impurities: Trace synthetic precursors and residual solvents, generally <1%
Synonyms: 4-(Methylamino)Cyclohexyl Methanesulfonic Acid, Trans configuration
Inhalation: Move person to fresh air without delay. Seek medical help if respiratory distress or coughing develops.
Skin Contact: Remove contaminated clothing. Wash affected area with copious running water and mild soap. Get medical attention for persistent redness or irritation.
Eye Contact: Rinse eyes immediately with water for at least 15 minutes, lifting eyelids frequently. Remove contact lenses if present and easy. Get prompt medical assessment.
Ingestion: Rinse mouth thoroughly if conscious. Do not induce vomiting unless directed by medical personnel. Seek immediate evaluation by a healthcare professional.
Most Important Symptoms: Burning sensation in mouth, throat, or respiratory tract, irritation, dermatitis, lacrimation.
Suitable Extinguishers: Water spray, dry chemical, alcohol-resistant foam, or carbon dioxide. Use agents appropriate for surrounding fires.
Unsuitable Extinguishing Media: High pressure water jets may spread material.
Specific Hazards: May emit toxic vapors of nitrogen oxides, sulfur oxides, and carbon oxides under combustion.
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective gear expected for all chemical fires.
Advice for Firefighters: Keep upwind; cool containers with spray water; prevent runoff from entering drains or waterways.
Personal Precautions: Avoid breathing dust or vapor; avoid contact with skin and eyes. Use chemical splash goggles, protective gloves, and laboratory coat.
Environmental Precautions: Prevent product from entering sewers, surface water, or ground water systems.
Containment and Clean-Up: Remove all ignition sources if safe. Scoop spilled solid into sealed containers using non-sparking tools. Wash area with plenty of water. Dispose according to local regulations.
Special Cleanup: Use HEPA-filtered vacuum or wet methods to avoid dust generation. Decontaminate tools and work surfaces after cleanup.
Safe Handling: Use in well-ventilated locations or chemical fume hood. Avoid forming dust and aerosols. Wear recommended personal protective equipment (PPE) during handling.
Safe Storage Conditions: Keep tightly closed in original packaging, in a cool, dry, and well-ventilated place. Store away from oxidizers, food, and incompatible materials.
Specific Requirements: Keep away from direct light, moisture, and accidental heating. Label all storage containers with content and hazard warnings.
Hygiene Measures: Do not eat, drink, or smoke while handling. Wash hands and exposed skin before breaks or leaving work area.
Exposure Limits: No specific occupational exposure limits set for this compound (check regional guidelines).
Engineering Controls: General exhaust, chemical fume hood, and splash-proof eyewash station in vicinity.
Personal Protection: Chemical-resistant gloves (nitrile or neoprene), safety goggles, lab coat or chemical apron, and face shield if splashing is likely.
Respiratory Protection: NIOSH-approved dust mask or full respirator if dust or aerosol may become airborne.
Environmental Exposure Controls: Prevent leaching into soil and water; install spill control measures and secondary containment as appropriate.
Appearance: White to off-white crystalline powder or solid
Odor: Faint, uncharacteristic chemical odor
Odor Threshold: Not established
pH (1% solution): Slightly acidic to neutral, depending on purity
Melting Point/Range: 145–158°C (literature or supplier data)
Boiling Point: Not available; decomposes before boiling
Flash Point: Not established for this compound
Evaporation Rate: Not applicable
Flammability: Not classified as flammable, may combust if exposed to high heat
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Relative Density: 1.2–1.3 (estimated)
Solubility: Soluble in water and polar organic solvents such as methanol and ethanol
Partition Coefficient: Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Decomposes upon strong heating, releases toxic fumes
Viscosity: Not applicable for solid forms
Chemical Stability: Stable under recommended handling and storage conditions. Sensitive to moisture and strong heat.
Reactivity: Reacts with strong oxidizers, acids, and bases; generates hazardous decomposition products if overheated.
Possibility of Hazardous Reactions: May generate toxic vapors under fire or improper storage.
Conditions to Avoid: Avoid exposure to sparks, static, excessive heat, and moisture.
Incompatible Materials: Strong oxidizers (e.g., peroxides, hypochlorites), concentrated acids or bases.
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide and dioxide, methylamine vapors.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Acute Toxicity: Harmful if swallowed, causes irritation of gut and digestive mucosa. Skin contact can lead to localized dermatitis. Inhalation of dust may cause short-term respiratory distress.
Chronic Toxicity: Long-term effects not fully characterized; regular exposure to cyclohexyl amine compounds has been linked to mucous membrane irritation.
Symptoms: Burning, itching, redness, coughing, headache, dizziness, nausea.
Immediate Effects: Mucous membrane irritation, dermatitis on skin contact.
Delayed and Chronic Effects: Potential for sensitization with repeated contact; not evaluated for carcinogenicity.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA.
Reproductive Toxicity: No data available for this specific compound.
Aspiration Hazard: Not classified.
Ecotoxicity: No direct testing data available; based on similar sulfonic acid derivatives, likely to be toxic to aquatic organisms at high concentrations.
Persistence and Degradability: May persist in water and soil; limited biodegradation in environment.
Bioaccumulative Potential: Partitioning might favor water phase, low predicted bioaccumulation.
Mobility in Soil: Soluble and mobile; potential to leach through soil if spilled in quantity.
Other Adverse Effects: Avoid uncontrolled release to environment, particularly near waterways, due to unknown long-term effects.
Recommendations: Clean up spills promptly, prevent discharge into drains, sewers, and waterways.
Waste Treatment Methods: Collect all waste materials and residue into labelled, sealed containers.
Incineration: Preferred disposal method under controlled, licensed facilities.
Landfill: Only as a last resort and in compliance with local environmental regulations.
Recycling: Not practicable for most laboratories.
Hazardous Waste Status: Assess status according to local, state, and federal guidelines; many sulfonic acid derivatives meet hazardous characteristics.
Packaging: Rinse containers thoroughly before disposal; treat as chemical waste.
UN Number: Not assigned for this specific compound
UN Proper Shipping Name: Not regulated under current UN Recommendations
Transport Hazard Class: Consult local guidelines—typically not classified as hazardous for transport in small quantities
Packing Group: Not assigned
Marine Pollutant: None specified; take care to prevent marine release
Special Precautions for Users: Secure packaging to prevent release; transport in sealed, labeled containers; avoid high temperatures, physical damage
International Inventories: Check if listed on TSCA, EINECS, DSL, or other chemical registries; registration may not apply for research uses.
SARA Title III (USA): Not subject to reporting under Sections 302, 304, 313
OSHA Hazard Classification: Classified as hazardous chemical
California Proposition 65: Not known to contain listed chemicals
REACH Status (EU): Pre-registration or notification may be required based on manufacture/import volumes
Other Local Regulations: Subject to national laboratory and industrial chemical safety regulations; consult safety, health, and environmental authorities for compliance.
