Product Name: Tert-Butyldimethylsilyl Trifluoromethanesulphonate
CAS Number: 69739-34-0
Synonyms: TBSOTf, tert-Butyldimethylsilyl triflate
Recommended Use: Reagent used in organic synthesis
Manufacturer: Specialist chemical suppliers and research chemical vendors
Emergency Contact: Refer to company-specific emergency phone lines; national Poison Centers
Classification: Corrosive to metals, skin, eyes; harmful if inhaled or swallowed
GHS Label Elements: Danger pictogram (corrosive, health hazard, exclamation mark)
Hazards: Causes severe skin burns and eye damage; may cause respiratory irritation; contact with moisture or water liberates toxic fumes
Target Organs: Eyes, skin, respiratory tract
Routes of Exposure: Inhalation, skin or eye contact, ingestion
Signal Word: Danger
Chemical Name: Tert-Butyldimethylsilyl Trifluoromethanesulphonate
Chemical Formula: C7H15F3O3SSi
CAS Number: 69739-34-0
Concentration: >98% (commercial standard)
Impurities: No significant impurities influencing classification
Inhalation: Remove from exposure, ensure fresh air, seek immediate medical advice if symptoms persist, avoid direct contact with vapors
Skin Contact: Remove contaminated clothing, rinse area thoroughly with water for at least 15 minutes, call medical help for persistent irritation or burns
Eye Contact: Rinse with plenty of water for at least 15 minutes, lift eyelids to ensure complete cleaning, get emergency medical attention
Ingestion: Do not induce vomiting, rinse mouth with water, seek urgent medical intervention
Most Critical Symptoms: Burns to skin or eyes, breathing difficulties, pain, redness or swelling; treat symptomatically under medical supervision
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, foam; avoid water jets as product reacts with water
Hazardous Combustion Products: Emits toxic fumes—carbon oxides, sulfur oxides, trifluoromethanesulfonic acid, silicon oxides under fire
Firefighter Protection: Wear self-contained breathing apparatus, chemical-resistant suits, boots and gloves; limit direct exposure
Special Procedures: Control runoff, use dry sand to prevent contamination, ventilate closed spaces after extinguishing
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid inhalation and contact with skin or eyes, wear protective equipment
Environmental Precautions: Prevent entry into drains, surface water or soil
Containment and Clean-Up: Absorb spillage with vermiculite or dry sand, collect in sealed chemical waste containers, clean contaminated area with plenty of water after initial control, avoid creation of dust or aerosols
Precautions for Safe Handling: Work in a fume hood or well-ventilated place, avoid breathing vapors, avoid skin or eye contact, wear appropriate gloves and face shields
Storage: Store tightly closed in original container, in a cool, dry, well-ventilated and clearly labelled corrosive storage room, segregate from bases, strong oxidizers, water and moisture sources
Specific Hygiene Measures: Wash hands and exposed skin thoroughly after handling, prohibit eating, drinking or smoking during use, remove contaminated clothing before entering eating areas
Engineering Controls: Chemical fume hood, local exhaust ventilation required
Personal Protection: Chemical-resistant gloves (nitrile, neoprene), full protective clothing, safety goggles, face shield, respiratory protection if exposure limits risk being exceeded
Occupational Exposure Limits: No specific threshold limit set, follow general guidelines for hazardous organosilicon or sulfonic acid derivatives
Environmental Controls: Prevent release to water systems, handle and dispose as hazardous chemical waste
Appearance: Colorless to pale yellow liquid
Odor: Slightly pungent
Odor Threshold: Not determined
pH: Not applicable (reacts with water)
Melting Point: -20 °C to -10 °C
Boiling Point: 75 °C - 80 °C at 15 mmHg
Flash Point: Not flammable under standard laboratory conditions
Evaporation Rate: Not determined
Flammability: Not classified as flammable
Vapor Pressure: Low at room temperature
Density: 1.27 - 1.32 g/cm³ at 20 °C
Solubility: Decomposes in water
Partition Coefficient (log Kow): Not determined
Decomposition Temperature: Decomposes before boiling
Viscosity: Liquid, not highly viscous
Chemical Stability: Stable under recommended storage conditions, decomposes on contact with water or moisture
Reactions: Vigorous reaction with water, alcohols, strong bases, oxidizing agents
Hazardous Decomposition: Toxic vapors of trifluoromethanesulfonic acid, silicon oxides, carbon monoxide, carbon dioxide
Polymerization: Not expected under normal conditions
Incompatible Materials: Strong bases, nucleophiles, water-active compounds, oxidizing agents, alcohols
Acute Toxicity: Limited quantitative data; expected to be highly corrosive to tissues upon exposure
Skin Corrosion/Irritation: Causes severe burns to skin and mucous membranes
Eye Damage/Irritation: Permanent eye damage possible on contact
Respiratory Sensitization: May cause coughing, respiratory distress, chemical pneumonitis with sufficient exposure
Chronic Effects: Prolonged or repeated exposure can aggravate skin and airway sensitivity
Carcinogenicity/Genotoxicity: Not listed by IARC, NTP or OSHA as carcinogenic; insufficient long-term study data
Other Risks: Ingestion may cause gastrointestinal tract burns, pain, vomiting, possible organ damage via absorption
Ecotoxicity: Data not available for product as a whole; highly toxic to aquatic life if released, due to acidity and transformation products
Persistence and Degradability: Expected to hydrolyze rapidly to trifluoromethanesulfonic acid, other persistent fluoroorganics
Bioaccumulative Potential: Low for intact molecule, but persistent hydrolysis products may remain in environment
Mobility in Soil: Highly mobile and soluble hydrolysis products
Other Adverse Effects: Avoid direct discharge into the environment
Waste Disposal: Dispose as hazardous chemical waste in accordance with local, regional and national regulations
Contaminated Packaging: Treat as hazardous waste, ensure complete emptiness before recycling or discarding
Precautions: Avoid generation of aerosols, handle only in approved facilities, never discharge to surface water or sewer systems
Disposal Methods: Contact licensed chemical waste disposal contractor
UN Number: 2920
Proper Shipping Name: Corrosive Liquid, Flammable, N.O.S. (contains tert-Butyldimethylsilyl triflate)
Hazard Class: 8 (Corrosive); subsidiary 3 (Flammable liquids)
Packing Group: II
Marine Pollutant: Not classified as marine pollutant, but avoid contact with water bodies
Label Required: Corrosive, Flammable Liquid
Special Precautions: Secure containers, label appropriately, transport in compliance with ADR/RID, IMDG, IATA standards
US Federal: Subject to OSHA Hazard Communication Standard; not specifically listed in SARA, CERCLA
Europe: Subject to REACH requirements, classified as corrosive (EUH statements apply)
Other Regulatory Listings: Not regulated under US TSCA Inventory as a chemical of concern; local workplace regulations require recording and safe storage
Labelling Requirements: GHS hazard pictograms and signal words
Workplace Control: Chemical hygiene plan, regular safety audits, robust training regime
