Chemicals like Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate rarely pop into everyday conversation, but the history behind this compound tells us plenty about modern research habits. Chemists in the mid-20th century looked for better ion-pairing agents to boost chromatography results. The push for more sensitive analysis techniques shone a light on compounds that could interact smoothly with both hydrophilic and hydrophobic substances. Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate came into play just as high-performance liquid chromatography advanced from a laboratory oddity into a pillar of pharmaceutical, biochemical, and environmental analysis. People built careers refining reactions involving this family of compounds, making them a regular feature in the protocol binders of university labs and R&D departments around the globe.
This compound doesn’t turn heads with bright colors or dramatic reactions. It looks like a white to off-white powder with a mild, sometimes salty odor. The chemical formula, C6H13NaO3S·H2O, tells a story about sodium cations making it more water-soluble, which turns out to be useful in countless analytical procedures. Molecular weight sits around 222.25 g/mol, and its melting point runs somewhere between 270°C and 280°C, depending on the hydration state. You can dissolve this compound in water without much fuss, and it won’t react unexpectedly with glassware or common buffers. The physical properties make it dependable in environments where precision matters.
Looking at Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate up close, its sulfonic acid group carries a strong negative charge, anchoring itself to sodium ions in solution. People use it to tweak ionic strength or change the selectivity in chromatography runs. Its structure stands up well against most acids and bases, and researchers often exploit this toughness to stretch experimental boundaries. Synthesis usually starts by sulfonating hexane, either through direct sulfonation or using more circuitous routes, depending on desired purity and cost. Neutralization with sodium hydroxide brings the product to its final salt form. This straightforward preparation means manufacturers can produce it on reasonable scales without elaborate setups or rare precursors.
It’s common to see Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate bottles with CAS Number 2832-45-3 and purity levels ranging from 97% to just shy of absolute. Labels usually include hydration state, hazard pictograms, and pH compatibility charts. On most safety data sheets, the main risks fall into two categories: skin and eye irritation, and disposition in wastewater. Experienced techs know repeated skin contact leaves irritation, so lab coats, safety glasses, and gloves need to become habits. Spills clean up with water and appropriate disposal, but pouring excess material down the drain causes headaches for municipal water treatment. Labs working with large samples document their handling and disposal rigorously, partly to avoid regulatory trouble, but also because somebody has to think about what gets left behind.
HPLC users reach for Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate to sharpen signals, reduce baseline drift, and coax out cleaner peaks when separating charged molecules. Pharmaceutical labs lean on it to ensure batch-to-batch consistency when confirming drug purity, especially for small-molecule drugs and peptides. Environmental researchers add it to mobile phases for water and soil testing, giving them an edge when detecting trace contaminants in complex backgrounds. Food scientists apply similar tricks, teasing apart sugars, vitamins, and even pesticide residues. Its versatility shows up wherever stability and ionic manipulation improve the odds of clear results. Some manufacturers experiment with it as an additive in specialty cleaning agents, exploring niche uses far removed from classic chemical analysis.
Chemicals often wear several hats, and Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate turns up under names like Sodium 1-Hexanesulfonate, Sodium Hexylsulfonate Monohydrate, and even Miscellaneous Anionic Surfactant C6. This variety in product names sometimes makes procurement a headache, especially for scientists in regions with strict import controls or language barriers. Researchers and purchasing agents spend time cross-checking CAS numbers to avoid communication breakdowns. The constant juggling reminds everyone how globalized, yet fragmented, modern science supply chains are.
Long-term toxicity studies paint this compound as generally low-risk for routine exposure levels, but the standard warnings about not inhaling powders or getting solutions in the eyes apply. Higher concentrations in aquatic environments raise subtle concerns about ecosystem impacts. There is a push for updated toxicological analysis, and a few journals have started reporting findings related to bioaccumulation in aquatic organisms and potential interference with enzymatic activity. As research digs deeper, nuanced findings on chronic exposure, especially in fish and amphibians, demand more attention. Regulatory bodies watch for irregularities, but as of today, responsible lab usage poses low risk to humans and moderate risk to sensitive wildlife if released without treatment.
Product specifications matter most in analytical work, so suppliers detail parameters like water content, heavy metal limits (often <10 ppm), and sodium levels. Labs calibrate their instruments using these details since stray contaminants have a way of fouling up baselines and extending analysis times. Vendors invest in better purification methods with every fresh customer complaint over inconsistency, leading to a gradual but noticeable rise in average product quality over the decades. Documentation, from certificates of analysis to lot traceability, meets demands not out of habit, but out of hard-earned experience from botched experiments.
R&D teams at chemical manufacturers sit down every quarter and try to carve out new areas for Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate. The compound’s surfactant-like properties let researchers experiment with it as a dispersant in nanoparticle synthesis or as a stabilizer in polymerization. Some are testing it in battery electrolyte formulations, targeting cleaner interfaces at electrode surfaces. A few years of dedicated research could uncover opportunities in pharmaceutical salt screening or even thin-film coatings, but funding cycles mean not every promising lead gets the attention it deserves. In this field, serendipity sometimes drives the most impactful discoveries, especially as interdisciplinary teams look beyond routine uses.
The future holds more than incremental improvements for compounds like Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate. As environmental regulations shift, pressure mounts to confirm biodegradability and screen for microplastic formation during waste processing. Instrument manufacturers design new detectors and columns that harness the subtle strengths of modern reagents. Green chemistry advocates press for less toxic and more sustainable analogs. Each of these directions shapes how this compound and its close cousins will turn up in labs a decade from now. As researchers push boundaries in separation science, environmental analysis, and specialty manufacturing, the demand for transparent sourcing, rigorous quality control, and robust toxicity data only grows stronger.
Most people never hear about Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate outside a research lab. Yet behind the scenes, this compound plays a backbone role in analytical chemistry. Its name isn’t catchy, but the jobs it takes on make a real difference in fields like pharmaceuticals, food safety, and environmental monitoring. I’ve worked on research projects where getting the details right meant trusting the chemistry right down to the reagents. This one always sticks out for its impact on separation science.
Chromatography isn’t just a word reserved for science fairs. It shows up in every quality-control lab that needs to separate out the ingredients in a complex mixture. In high-performance liquid chromatography, the accuracy of the split between molecules rests on what goes into the mobile phase. Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate works as an ion-pairing agent, improving separation of tough analytical targets like basic drugs, amino acids, or pesticides. I’ve watched frustrated chemists spend days getting blurry results, only to see clear peaks after adding this compound. That means clearer answers, faster approvals, and safer products down the line.
Pharmaceuticals need testing before they ever reach the pharmacy shelf. Regulatory agencies hold drug manufacturers to strict standards because patient safety starts at the molecular level. Running HPLC with Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate gives labs the power to spot impurities that could cause harm or reduce potency. These tests aren’t optional add-ons; people’s lives depend on the accuracy they offer. As someone who’s watched clinical trials grind to a halt because the analytical chemistry side faltered, I respect every ingredient that helps keep the process moving.
Clean water and uncontaminated food form the baseline of public health. Governments and companies run constant monitoring of everything from pesticides in vegetables to contaminants in tap water. Laboratories use Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate to separate out groups of molecules that otherwise sneak under the radar. In practical terms, that means catching banned antibiotics in fish or ensuring that infant formula meets nutritional promises. The numbers coming out of those labs shape inspection protocols and product recalls, not only for safety but for consumer trust.
There’s a catch: using chemicals with this much influence calls for careful handling. Not every new technician in a lab knows the difference between two similar-looking white powders. Training needs to focus on proper use, safe handling, and documentation at every step. I’ve seen errors crop up not from malice, but because the protocols got sloppy and the records didn’t match the reality of what happened at the instrument bench.
Adding more transparency to supply chains also helps. Labs want to know their chemicals have reliable origins and clear provenance. That puts pressure on suppliers to tighten up documentation and helps build confidence in the results everyone depends on. Mistakes with these ingredients have ripple effects beyond a single batch or a single patient, so the margin for error stays razor-thin.
The biggest step forward comes from better policies and smart daily practice. Regular audits, updated safety protocols, and investment in education for new lab staff create a culture where chemicals like Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate get used with respect. These efforts don’t just guard against accidents—they raise the standard for all research and testing. In my experience, small improvements here pay off with tighter results, safer products, and stronger accountability up and down the line.
Anyone who’s spent time in a science lab knows that understanding a compound’s formula is more than just a chemistry exercise. It translates directly into how well a procedure works, how a material behaves, and what kind of risk you’re working with. Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate comes with the formula C6H13NaO4S·H2O. This breaks down to a six-carbon chain, a sulfonic acid group, and a sodium atom, bound to a single water molecule. You might see it listed in the lab as sodium 1-hexanesulfonate monohydrate.
Every chemist’s memory bank holds a few key numbers: Sodium’s atomic mass, carbon’s six slots per ring, and the weight water adds. With sodium 1-hexanesulfonate monohydrate, the formula combines the sodium salt of a sulfonic acid with a straight six-carbon tail, then waters it down a touch—literally. That’s where the monohydrate tag comes from. This hydration not only shifts the weight, it also changes handling and solubility, which absolutely matters in chromatography work or sample preparation.
Getting the molecular weight right isn’t just a back-of-the-envelope calculation. Labs operating under GMP or industry standards need spot-on figures to dose chemicals or troubleshoot technical issues. For C6H13NaO4S·H2O, the sum looks like this:
Add it all up, and you hit a total of about 222.27 grams per mole. Precise numbers ensure formulations don’t run risk of overdosing or falling short, which in analytical methods can muddy up entire batches of results. Just one decimal off can mean recalibrating expensive equipment or repeating long prep cycles.
Many folks see chemical names and think, “Just technical detail.” A closer look reveals a story about accuracy, safety, and even keeping research reproducible worldwide. In one biopharma startup I worked at, slight confusion over hydrate versus anhydrous salt meant delayed production runs. Fixing it meant digging through scientific databases, cross-checking CAS numbers and getting proof from suppliers—the only way to guarantee we weren’t introducing error into the finished medicine.
Regulatory agencies expect every lot to meet tight specs, and an incorrect molecular weight on your certificate of analysis spells trouble fast. Honest, transparent sourcing and double-checking everything against original chemical documentation builds trust with auditors, team members, and clients alike. Working from a place of shared, factual chemical understanding ultimately pushes scientific work forward, avoiding wasted time or safety risks.
Thoughtful handling of Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate always circles back to the numbers. Molecules don’t lie, but people handling data sometimes overlook a hydration difference or cut corners on transparency. Teams that focus on disciplined sourcing, documentation, and training end up saving time—and lives—in the long haul. Getting familiar with chemical formulas and molecular weights isn’t just “book knowledge.” It’s a real-world skill that pays off every single shift in the lab.
Every lab develops its own personality. Some are crammed and humid, others cold as an ice chest. No matter the setup, attention to how chemicals live on the shelf matters. Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate isn’t some ordinary kitchen salt. This compound doesn’t care about sentiment or routine—it cares about its environment. Over my years of wrangling everything from finicky solvents to stubborn acids, poor preparation always comes back to bite. Storing this compound asks for a dose of respect and good common sense.
Dampness turns even the sturdiest chemicals into a gamble. Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate picks up moisture from the air faster than you’d expect. If left in a humid corner, it cakes and clumps, losing its precise structure. That inconsistency ruins not only the chemical, but also the experiments and machinery that count on it. Imagine preparing a buffer and realizing it’s off because the powder’s absorbed half the room’s water. Labs know this frustration too well.
Keep this chemical in a tightly sealed, non-porous container. Polypropylene or amber glass jars with screw caps work well. Resealing after every use isn’t a hassle, it’s a habit worth forming. Bring containers to room temperature before opening, especially if they’ve been chilled to avoid condensation forming inside. Even a few droplets of water sneaking in can spell trouble.
Dust and other chemicals don’t mix well with it either. Keep it out of direct sunlight and away from heat sources. I once saw a bottle sitting inches away from a stirring hotplate—turns out even a mild heat source turns “store at room temperature” into a recipe for ruined powder. Aim for a cool, dry place, and avoid extreme temperatures or freezing—cold may not ruin it, but repeated thawing invites clumps and a mess later.
Proper labeling is one trick forgotten during busy stretches. Permanent marker on an obvious tag stops confusion during chaotic times. List the date received and opened as well to keep on top of shelf life. If you’re storing several sulfonic acids, don’t crowd similar-looking bottles. Even skilled chemists can mix them up under pressure. Keeping incompatible chemicals—acids, oxidizers, strong bases—away from Syn1-Hexanesulfonic Acid salts rules out disastrous cross-reactions. An organized shelf does more to protect a lab than the most expensive fire extinguisher.
Small spills get overlooked, especially in busy labs. But treat every bit of the compound seriously. Clean up instantly and store all containers upright. Even if it sounds obvious, I’ve seen too many tilted, unlabeled jars left on benches, waiting to topple. If the chemical escapes into the air or gets onto skin, it’s not just an inconvenience—safety and health are at risk. Wearing gloves and goggles, even when handling sealed containers, keeps rash incidents at bay.
Some labs benefit from secondary containment. One mishap with humidity can ruin a batch worth hundreds of dollars. Desiccators, silica gel packets, or dry cabinets work wonders. For larger stocks, splitting the batch into smaller containers lessens risk. If a container gets contaminated or absorbs moisture, only part of your inventory takes the hit. That small change means more than firefighting ruined stock.
Good storage is not just about compliance lists or ticking off protocols. It starts with remembering why we store right—to keep people safe, protect valuable research, and stretch budgets. Leaning into reliable habits, keeping things dry, organized, and labeled, will always pay off. A conscientious approach beats expensive fixes and hair-raising close calls.
Chemicals always bring questions about safety, no matter how often you see them in a laboratory. Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate pops up pretty often in chromatography, especially with HPLC testing. The bright white powder looks harmless at first, pouring easily from its jar, but a lot more sits beneath the surface. Years working in labs have set one thing straight for me: appearances can mislead.
This chemical falls into the sulfonic acid class. Powders like these tend to linger in the air while being handled. Whenever I have prepared samples with it, my nose picks up a faint odor, telling me dust might be present. Even without visible clouds, inhalation risk is real. The European Chemicals Agency (ECHA) labels these compounds as irritants. Small particles drifting near your face find their way into your mouth or nose, leading to throat and eye irritation. A slip without goggles or a dust mask can land you a nasty cough, or worse, swelling in the membranes lining your airway.
Manufacturers publish safety data sheets for this very reason. They put out clear warnings: keep the chemical off your skin and out of your eyes. In my own experience, close skin contact itches, with redness after a few hours if you forget proper handwashing. Gloves always come first. Spills get rinsed off right away with lots of water. Eyes require an eyewash station.
Workers sometimes minimize the threat, thinking low-toxicity means harmless. That attitude gets people into trouble. Syn1-Hexanesulfonic Acid sodium salt monohydrate has low acute toxicity by standard laboratory definitions, but low doesn’t mean zero. If ingested, even small amounts can lead to stomach upset, and people with respiratory problems or sensitive skin can see their symptoms flare up.
Chronic exposure risks haven’t been well studied. The fact remains, decades of chemical safety history show repeated exposure to irritants builds up inflammation or even sensitization over time. In simple terms: repeated careless use turns minor hazards into long-term health problems.
Taking shortcuts in cleanup or protection doesn’t save time in the end. In the labs where I’ve worked, we always kept a full set of personal protective equipment on hand: gloves, goggles, lab coats, and a working fume hood. Spills happen. A simple paper dust mask won’t cut it; a proper particulate respirator protects your lungs when weighing out these acid salts.
Evidence from workplace incident reports shows a clear pattern. Most injuries or exposures happen during transfer, weighing, or accidental spills. Proper scoopulas, slow pouring, and never working outside a ventilated area make all the difference. It just isn’t worth risking your health for a shortcut.
The best solution starts with reliable training. Every chemist learns the basics, but refreshers once a year catch slip-ups before they cause trouble. Having the right clean-up kit ready and a written spill response plan makes a hazardous moment a routine hiccup. For disposal, strict chemical waste policies keep labs, people, and the environment safe. Drain disposal of acid salts puts both pipes and water systems at potential risk, so collection for specialized waste treatment stays standard.
Chemicals like Syn1-Hexanesulfonic Acid Sodium Salt Monohydrate don’t spark headlines in the public eye, but they remind everyone that safety rests in the small decisions made hundreds of times each day. Gloves on, eye-protection secured, and waste handled right—each lab worker shapes a culture where health stays front and center.
Purity makes or breaks a chemical’s performance. In a world where labs chase accurate results, nobody has patience for surprises from a poorly characterized reagent like Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate. From running HPLC separations to quality control of pharmaceuticals, small differences in purity can set off a domino effect of headaches. I learned this years ago during an internship at a food-safety lab—one impure chemical meant hours wasted troubleshooting peaks that just would not resolve. Not fun, not efficient, and definitely not safe.
Manufacturers usually supply Syn1-Hexanesulfonic Acid, Sodium Salt Monohydrate in "analytical" or "reagent" grade forms. Most commercial offers sit at about 99% purity or higher. Go through catalogues from names like Sigma-Aldrich or Thermo Fisher—most list the assay by dried substance, making up that headline number. That remaining 1% covers trace moisture, inorganic salts, and sometimes organics from synthesis or packaging. Higher purity, sometimes labeled as "HPLC grade," can hit 99.5% or above. These are targeted at chromatography or biochemical research, where even a trace contaminate can shift retention times or cloud up spectra.
A decent grade comes with a certificate of analysis. I have always insisted on reading them before signing off for the lab. These certificates spell out limits: heavy metals, sulfate, chloride, residue after ignition, and water content. The reason? Sulfonic acid derivatives can drag along sodium sulfate or even small-chain analogues made during the synthesis. For chromatography, those side products kick up baseline noise or muddy your separation, and even a whiff of iron will ruin some detections.
Cost saving sometimes leads buyers to accept lower-grade batches, especially for teaching labs or bulk cleaning use. In teaching, the risk may seem low, but I’ve seen students sweating over inexplicable results traced back to sub-par chemicals. Low purity means more background signal, drifts in retention time, or (worst case) chemical reactions you never intended. For anyone aiming for credible research or regulatory approval, this shortcut never pays off.
Skilled chemists can’t do much without reliable materials, so paying attention to purity specification is a baseline. Before placing any order, check the latest online certificate of analysis, compare it with your protocol requirements, and make sure the batch is recent. Some labs even archive portions of new stock and run small-scale control tests before adopting a new lot for critical work. This may sound obsessive, but it spares you stress and maintains trust in complex data sets.
Quality starts at the source. Chemical suppliers can tighten specifications only if labs keep pushing them to disclose impurity profiles, batch history, and transport conditions. As more sectors demand transparency, expect suppliers to extend quality documentation and include routine impurity screens. Holding vendors to these standards may bump prices a bit, but it protects researchers and industries from chaos in their day-to-day work.
True quality control means treating chemical purity as a foundation, not a feature. In my experience, paying close attention to those decimal points in purity percentages keeps both science and industry headed in the right direction.
| Names | |
| Preferred IUPAC name | sodium 1-hexanesulfonate monohydrate |
| Other names |
1-Hexanesulfonic Acid Sodium Salt Monohydrate Sodium 1-hexanesulfonate monohydrate Sodium hexane-1-sulfonate monohydrate Hexane-1-sulfonic acid sodium salt monohydrate |
| Pronunciation | /sɪnˈwʌn hɛkˈseɪn sʌlˈfɒnɪk ˈæsɪd ˈsəʊdiəm sɔːlt ˌmɒnəˈhaɪdreɪt/ |
| Identifiers | |
| CAS Number | 283919-46-6 |
| 3D model (JSmol) | `3D model (JSmol)` string for **1-Hexanesulfonic Acid, Sodium Salt Monohydrate**: ``` CCCCC[S](=O)(=O)O.[Na].O ``` This is the **SMILES** notation string, commonly used for 3D modeling in JSmol and related software. |
| Beilstein Reference | 1718738 |
| ChEBI | CHEBI:91229 |
| ChEMBL | CHEMBL2184889 |
| ChemSpider | 163527 |
| DrugBank | DB14210 |
| ECHA InfoCard | ECHA InfoCard: 100947-130-4 |
| EC Number | 262-372-5 |
| Gmelin Reference | 1100393 |
| KEGG | C02363 |
| MeSH | D06.472.699.587.447.875.150 |
| PubChem CID | 13770 |
| RTECS number | MW4725000 |
| UNII | 5M8U3759FT |
| UN number | UN1993 |
| Properties | |
| Chemical formula | C6H13NaO4S·H2O |
| Molar mass | 274.29 g/mol |
| Appearance | White to Off-white Powder |
| Odor | Odorless |
| Density | 1.35 g/cm³ |
| Solubility in water | soluble in water |
| log P | -3.1 |
| Acidity (pKa) | 1.2 |
| Basicity (pKb) | 12.0 (pKb) |
| Magnetic susceptibility (χ) | -76.6e-6 cm³/mol |
| Refractive index (nD) | 1.420 |
| Dipole moment | 9.10 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 356.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of combustion (ΔcH⦵298) | -3836.8 kJ/mol |
| Hazards | |
| Main hazards | Harmful if swallowed. Causes serious eye irritation. Causes skin irritation. |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled. |
| Precautionary statements | Precautionary statements: P261, P280, P305+P351+P338, P337+P313 |
| NFPA 704 (fire diamond) | 1-0-0 |
| Flash point | > 102.7 °C |
| Lethal dose or concentration | LD50 Oral Rat 2500 mg/kg |
| LD50 (median dose) | LD50 (median dose): Mouse oral LD50 = 1750 mg/kg |
| NIOSH | NA |
| PEL (Permissible) | PEL (Permissible): Not established |
| REL (Recommended) | 50 mg/L |
| IDLH (Immediate danger) | Not established |
| Related compounds | |
| Related compounds |
Hexanesulfonic Acid Sodium Hexanesulfonate 1-Hexanesulfonic Acid 1-Hexanesulfonic Acid Sodium Salt Hexane-1-sulfonic Acid Sodium Salt Hexanesulfonic Acid Sodium Salt n-Hexanesulfonic Acid Sodium Salt |
