Product Name: Sodium 4-(2-Hydroxyethyl)piperazin-1-ylethanesulphonate
Synonyms: HEPES Sodium Salt
CAS Number: 75277-39-3
Recommended Use: Buffer agent, laboratory reagent
Company Identification: Manufacturer contacts listed on packaging
Emergency Phone Number: Check local distributor or package documentation for up-to-date emergency contacts
GHS Classification: Not considered a hazardous substance under GHS criteria
Hazard Statements: May cause mild skin or eye irritation, avoid direct or prolonged exposure
Precautionary Statements: Wash hands thoroughly after handling, wear eye and face protection
Signal Word: None required
Pictograms: No pictograms mandated
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Symptoms: May provoke discomfort or irritation at high concentration, usually minimal risk
Chemical Name: Sodium 4-(2-Hydroxyethyl)piperazin-1-ylethanesulphonate
Molecular Formula: C8H17N2NaO4S
Molecular Weight: 260.29 g/mol
Concentration: 100% (pure substance)
Impurities: Trace inorganic salts may be present
Other Ingredients: None
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and continue rinsing. Seek medical attention if irritation persists.
Skin Contact: Wash with plenty of soap and water. Remove contaminated clothing. Seek medical attention if symptoms continue.
Ingestion: Rinse mouth with water. Do not induce vomiting unless instructed by medical personnel. Get medical attention if feeling unwell.
Inhalation: Move to fresh air. Get medical attention if symptoms develop and persist.
Most Important Symptoms: Redness, irritation in case of contact
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Unsuitable Extinguishing Media: None specified for this material
Specific Hazards: Combustion generates toxic fumes: carbon oxides, nitrogen oxides, sulfur oxides, and sodium oxides.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing.
Special Procedures: Move containers away from fire area if this can be done without risk.
Hazardous Combustion Products: Irritant gases or vapors may be released in fire
Personal Precautions: Avoid dust formation. Wear appropriate protective gear including gloves, lab coat, and goggles.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains, surface water, or soil.
Methods for Cleanup: Sweep up without creating dust. Place in a suitable container for disposal. Clean spill area thoroughly.
Reference to Other Sections: For waste disposal, see disposal considerations below.
Handling: Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Do not breathe dust. Implement good chemical hygiene practices: wash hands after use, keep work area tidy.
Storage: Store tightly closed in a cool, dry, and well-ventilated area. Protect from moisture and incompatible materials. Avoid excess heat or direct sunlight.
Storage Conditions: Room temperature, away from strong acids or oxidizing agents.
Incompatibilities: Strong oxidizers, acids
Exposure Limits: No specific occupational exposure limits established.
Ventilation: Use in a chemical fume hood or with adequate mechanical ventilation.
Personal Protective Equipment:
Appearance: White crystalline or powder solid
Odor: Odorless
Odor Threshold: Not available
pH (1% solution): Typically 7.2–7.4
Melting Point: > 300°C
Boiling Point: Not available
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not flammable
Vapor Pressure: Negligible
Vapor Density: Not available
Solubility: Soluble in water (50 g/L at 20°C)
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Not applicable
Chemical Stability: Stable under recommended handling and storage conditions
Possibility of Hazardous Reactions: Not anticipated under normal use
Conditions to Avoid: Excessive heat, moisture, strong oxidizers, strong acids
Incompatible Materials: Oxidizing agents, strong acids
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, sulfur oxides, sodium oxides released in a fire
Reactivity: No hazardous reactions observed during normal laboratory use
Acute Toxicity: Low oral and dermal toxicity expected (no data available for LD50 in humans)
Skin Corrosion/Irritation: May provoke mild to moderate irritation on repeated contact
Serious Eye Damage/Irritation: May cause eye irritation
Respiratory Sensitization: No data available
Skin Sensitization: Not expected to cause sensitization
Germ Cell Mutagenicity: Not classified as mutagenic
Carcinogenicity: Not listed by IARC, NTP, OSHA, or ACGIH
Reproductive Toxicity: No evidence to suggest reproductive or developmental effects
Specific Target Organ Toxicity: No target organ effects observed
Symptoms of Overexposure: May include stomach upset, headache, dizziness if large quantities are ingested
Delayed and Immediate Effects: No delayed effects documented in scientific literature
Ecotoxicity: Expected to pose low risk to aquatic organisms due to low acute toxicity
Persistence and Degradability: Not rapidly biodegradable, expected to be persistent in the environment
Bioaccumulation: Not anticipated to bioaccumulate in aquatic organisms
Mobility in Soil: High water solubility increases mobility through soil
Other Adverse Effects: No data identifying potential for ozone depletion, photochemical ozone creation, or global warming impacts
Disposal Methods: Collect material and dispose at a chemical waste facility according to local, state, and national regulations
Contaminated Packaging: Empty containers should be rinsed before recycling or disposal. Consult local waste authorities for recommendations on container and unused product disposal
Special Precautions: Do not allow material to enter surface water, stormwater drains, or soil in high concentrations
UN Number: Not regulated for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Classes: Not assigned
Packing Group: Not assigned
Environmental Hazards: Material not classified as hazardous for air, sea, or land transport
Transport Precautions: Package securely to avoid breakage and spillage during transit
TSCA Status: Listed on the Toxic Substances Control Act Inventory
REACH Registration: Check local guidelines for registration status in Europe
SARA Title III Sections 302/304/313: Not listed
California Prop 65: Not listed
Workplace Classification: Not classified as a hazardous material under OSHA and WHMIS
Labeling Requirements: No label elements required beyond standard workplace safety information
Other National/International Regulations: Subject to national and regional regulatory controls concerning chemical inventory and worker safety
