Product Name: Reaction Mass Of 1-Phenylethanamine, Methanesulfonic Acid, and 2-Amino-2-(Hydroxymethyl)Propane-1,3-Diol
Chemical Formula: Mixture; not applicable
Relevant Uses: Laboratory chemicals, synthesis of substances
Supplier: Specify supplier information: name, address, telephone number
Emergency Phone: Include local emergency numbers for immediate advice or incident support
Recommended Restrictions: Restricted to professional users with training in chemical handling
Classification: Corrosive to skin and eyes, may cause severe burns and eye damage, causes irritation to respiratory system, may be harmful by inhalation, ingestion, or skin contact
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, harmful if swallowed, may cause respiratory irritation
Pictograms: Corrosive (GHS05), Exclamation mark (GHS07)
Precautionary Statements: Avoid breathing dust, wear protective gloves, clothing, eye and face protection, wash hands thoroughly after handling, use only outdoors or in well-ventilated area, store locked up
Other Hazards: Solutions may decompose under heat releasing hazardous gases, contributed by methanesulfonic acid decomposition
1-Phenylethanamine: Approx. 40–60%, C8H11N, CAS Number: 98-84-0, Acute toxicity, irritant
Methanesulfonic Acid: Approx. 20–40%, CH4O3S, CAS Number: 75-75-2, Corrosive, serious eye damage
2-Amino-2-(Hydroxymethyl)Propane-1,3-Diol (Tris): Approx. 10–30%, C4H11NO3, CAS Number: 77-86-1, Mild irritant
Impurities: Trace solvent or moisture, content under 1%
Inhalation: Move person to fresh air without delay, consult doctor if symptoms such as coughing, shortness of breath, or irritation persist, provide artificial respiration if breathing becomes difficult
Skin Contact: Take off contaminated clothing immediately, wash affected area thoroughly with soap and water for at least 15 minutes, seek medical attention if discomfort continues
Eye Contact: Rinse carefully with plenty of water for at least 15 minutes, lift eyelids occasionally, remove contact lenses if present and easy to do, obtain medical help without delay
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek medical assistance immediately, give water to drink if conscious
Notes to Physician: Treat symptomatically based on patient’s clinical condition, monitor for signs of acid-base imbalance or allergic reaction
Suitable Extinguishing Media: Use water spray, dry chemical powder, alcohol-resistant foam or carbon dioxide to extinguish
Unsuitable Media: Do not use high-pressure water jets as they may spread chemical
Specific Hazards: Thermal decomposition releases toxic and corrosive vapors including nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Wear full chemical protective suit and self-contained breathing apparatus
Special Precautions: Move containers away from fire if it can be done safely, cool fire-exposed tanks using water spray, prevent runoff into drains or watercourses as acidic or basic solutions can cause damage to aquatic environment
Personal Precautions: Evacuate unnecessary personnel, avoid contact with skin, eyes or clothing, provide adequate ventilation
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid release into sewers or waterways, use barriers to contain spill
Cleanup Methods: Neutralize spill with suitable neutralizing agent (lime or sodium bicarbonate for acid), absorb with inert material such as soil, sand, or vermiculite, collect in tightly closed containers for disposal, wash area with large amount of water avoiding splash
Reference to Other Sections: See exposure controls and disposal considerations for more details
Precautions for Safe Handling: Handle in a chemical fume hood with proper air extraction, prevent contact with skin, eyes, and clothing, do not breathe fumes, avoid eating, drinking, or smoking when handling product, label containers clearly
Storage Conditions: Store in tightly closed containers in a cool, dry, well-ventilated area away from direct sunlight and incompatible substances such as oxidizers, bases, or reducing agents, keep locked when not in use
Incompatible Materials: Alkalis, oxidizing materials, reducing agents or bases, storage with acids other than methanesulfonic acid may cause violent reaction
Packaging: Use containers made of compatible material, polyethylene or glass recommended for acids
Engineering Controls: Work in fume hood or use local exhaust ventilation, provide safety showers and eyewash facilities in work area
Exposure Limits: Methanesulfonic acid: TLV not established; use lowest reasonable exposure; 1-Phenylethanamine: TWA not established but use good practice limits
Personal Protective Equipment: Wear safety goggles or face shield, chemical-resistant gloves (nitrile, neoprene), lab coat or apron, appropriate respiratory protection if exposure limits likely to be exceeded
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing immediately, keep workplace clean
Appearance: Colorless to pale yellow liquid or viscous mass
Odor: Slight fish-like or ammoniacal odor
Odor Threshold: No established data
pH: Strongly acidic to neutral depending on relative proportions
Melting Point/Freezing Point: Variable (may not present uniform melting point)
Boiling Point: Not well defined for mixture; for individual components: methanesulfonic acid 167°C, 1-Phenylethanamine 195°C
Flash Point: >80°C (mixture may suppress individual component flammability)
Evaporation Rate: Data not available
Flammability: Not classified as flammable
Vapor Pressure: Low; mixture likely viscous, little vapor at room temperature
Solubility: Readily soluble in water
Partition Coefficient (n-octanol/water): Not available for mixture
Auto-ignition Temperature: Not established for blend
Decomposition Temperature: Decomposes above 180°C
Viscosity: Variable; likely moderate to high
Reactivity: Reacts vigorously with bases and oxidizers
Chemical Stability: Stable in original package under recommended storage conditions, decomposes slowly when exposed to air or moisture
Hazardous Reactions: Mixing with strong alkalis, strong oxidizers, or strong reducing agents can produce heat, toxic gases
Conditions to Avoid: Excessive heat, open flame, direct sunlight, storage with incompatible materials
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide, possible amines
Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Severe burning pain, ulceration of mucous membranes, eye injury, coughing, shortness of breath, sore throat, abdominal pain, nausea
Acute Toxicity: Methanesulfonic acid: LD50 (oral, rat) 1600 mg/kg; 1-Phenylethanamine: LD50 (oral, rat) 820 mg/kg; Tris low toxicity
Skin Corrosion/Irritation: Causes burns
Serious Eye Damage/Irritation: Causes serious damage
Respiratory Sensitization: Not classified as respiratory sensitizer, but may cause irritation
Germ Cell Mutagenicity/Carcinogenicity: No classification; not evaluated for mixture
Repeated Dose Toxicity: Prolonged exposure may cause chronic skin or respiratory irritation
Toxicity: Methanesulfonic acid and 1-Phenylethanamine are toxic to aquatic life with long lasting effects if released in quantity
Persistence and Degradability: Methanesulfonic acid is biodegradable, 1-Phenylethanamine and Tris degrade slowly in environment
Bioaccumulation Potential: Not expected to bioaccumulate significantly
Mobility in Soil: High solubility, may move rapidly if spilled outdoors
Other Adverse Effects: Low persistence for methanesulfonic acid, but acute risk for aquatic organisms, avoid release to environment
Waste Treatment Methods: Treat as hazardous chemical waste, neutralize with suitable alkaline solution before disposal, collect in labeled containers
Disposal of Product: Dispose of in accordance with local, state, and federal regulations through licensed chemical waste contractor
Disposal of Packaging: Decontaminate containers before reusing or recycling, puncture or crush to prevent reuse, dispose of according to chemical waste protocols
Special Precautions: Do not dispose of down the drain, avoid contaminating surface, ground, or water systems
UN Number: UN3265 (Corrosive liquid, acidic, organic, n.o.s., includes methanesulfonic acid)
UN Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s.
Transport Hazard Class: 8 (Corrosive)
Packing Group: II
Environmental Hazards: Product harmful to aquatic organisms, marine pollutant cannot be excluded
Special Precautions: Ensure container integrity for transport, keep upright and secure against movement, transport with relevant shipping papers
Classification under Regulation: Classed as hazardous according to OSHA (US), CLP/GHS (Europe), WHMIS (Canada)
Labeling Requirements: GHS symbols for corrosive and health hazard
SARA Title III (USA): Sections 311/312 (immediate health hazard)
TSCA Status: Ingredients listed or exempt
REACH Status: Components registered or exempt; check for substance-specific restrictions in European countries
Other Country Requirements: Confirm with local environmental, health and safety guidelines for additional compliance
