Curiosity has always driven chemistry forward, and N-Cyclohexylsulphamic Acid is no exception. Laboratories started looking into sulfonamide derivatives before the middle of the 20th century—much of the drive came from a need to modify properties of existing acids and to build specialty components for dyes and stabilizers. German and Japanese chemists seemed especially active in the development of cyclohexyl-substituted compounds, not just for direct industrial purposes, but to explore new ways of extending the life and effectiveness of more mainstream products. With each experiment, more practical knowledge piled up, leading to commercial synthesis and a steady stream of technical papers. Even today, researchers occasionally dig into old archives to revisit patents and methods from this era, finding lessons that still help with troubleshooting scale-up and purity issues.
N-Cyclohexylsulphamic Acid steps onto the scene as a unique sulfonamide known for a versatile role in the chemical industry. Structurally, it links a cyclohexyl group to a sulfamic acid backbone, bringing together hydrophobic and hydrophilic properties in one molecule. Manufacturers like it for its stability in several environments and its willingness to form salts and derivatives easily. Unlike more complicated organic acids, this one balances effectiveness with a straightforward synthesis.
The appearance of N-Cyclohexylsulphamic Acid shows itself as a white, crystalline powder. Not much odor comes off, which lowers concerns about handling on a lab scale. Solubility numbers grab attention: moderate in water, better in polar organic solvents. Melting points usually land above 160°C, hinting at robust intermolecular forces from the sulfonamide group. Typical samples resist hydrolysis under neutral conditions. On the pH scale, its mildly acidic nature stands out, shaped by the electron-withdrawing sulfonyl group combined with bulk from cyclohexyl. That kind of physicochemical behavior translates into selective reactivity—ideal if you’re tweaking a process to favor certain reaction pathways.
Industry practice demands reliable specs for every batch. Purity often reaches 98% or higher, with stringent controls on moisture, ash, and residue. Reputable suppliers provide a certificate of analysis detailing exact appearance, pH in solution, total sulfur content, melting point, and loss on drying. Chemical drums or poly-lined bags come stamped with the CAS number, standard hazard pictograms, date of manufacture, and full hazard classification under GHS. Many facilities track trace metals—such as iron and calcium—that could interfere with downstream uses, particularly in electronics or high-purity water applications.
Synthetic routes tend to start with cyclohexylamine and chlorosulfonic acid. Bringing these together in controlled conditions triggers nucleophilic substitution, spawning N-Cyclohexylsulphamic Acid and hydrogen chloride as the main byproduct. Temperature control means everything here—jump above recommended levels and yields drop as byproducts creep in. For commercial runs, process engineers turn to glass-lined reactors to sidestep corrosion issues. After the reaction, common practice involves filtration, washing, and controlled crystallization to maximize product recovery and purity. Solvent choice and crystal handling often influence scalability as much as raw material costs.
N-Cyclohexylsulphamic Acid brings a mix of stability and controllable reactivity. It reacts predictably with strong bases to form cyclohexylsulfamate salts, giving chemists a lever to tweak solubility or reactivity on demand. Electrophilic substitution at the cyclohexyl ring is possible, but requires either metal catalysts or specific activation. Some specialist labs convert the compound into other N-cyclohexyl derivatives by connecting different functional groups to the sulfonamide nitrogen. This adaptability opens up routes into dye intermediates, corrosion inhibitors, and specialized surfactants.
Trade catalogs sometimes use alternate names for this acid: Cyclohexylsulfamic Acid, N-Cyclohexylsulfamate, or simply Cyclohexylamide Sulfonic Acid. A few suppliers label it under brand-specific codes, but IUPAC naming conventions keep confusion at bay. That consistency helps end-users track down technical data sheets and regulatory information, avoiding costly errors when scaling up or substituting in different geographical regions. Cheminformatics databases, whether from Sigma-Aldrich or PubChem, rely on these names to cut through ambiguity in product tracking.
Lab personnel focus on skin and eye protection because solid and dust forms can irritate. Inhalation hazards stay relatively low in well-ventilated rooms but escalate during powder transfers. SDS documentation flags mild acute toxicity, recommending gloves, goggles, and, if handled in large quantities, a dust mask. Strict instructions exist for spill response: scoop up solids, avoid dust formation, and keep material away from incompatible chemicals like strong oxidizers. Packaging needs to fight off moisture; otherwise, caking and hydrolysis can threaten performance. Clear labeling and consistent training fight against costly slip-ups.
N-Cyclohexylsulphamic Acid finds real workhorse use as an intermediate in organic synthesis. Pharmaceutical industries sometimes draw on its cyclohexyl group to build bioactive molecules. In water treatment, it acts as a specialized additive, modifying pH or tying up trace metals in solution. Coloring agents call on derivatives for improved fixation and wash-fastness in textiles, especially where regular sulfonamides would lose out. Agrochemical development leans on such compounds to tweak the balance between hydrophobicity and reactivity. My own past experience in a dye lab showed how a tiny change—swapping a methyl for a cyclohexyl—shifted color shade and fastness without reworking the entire production line.
Constant pressure exists to innovate both in formulation and downstream chemistry. Researchers in university and industry test fresh catalysts for more efficient synthesis, pushing for less environmental impact and higher selectivity. Green chemistry principles steer some groups to try water-based or solvent-free routes, chipping away at waste and cleanup costs. Analytical chemists chase ever lower detection limits for impurities, especially where Japanese or European standards edge past minimums found elsewhere. A handful of electrodevelopment firms check new derivatives as corrosion inhibitors, hoping for longer-lasting components inside heat exchangers and reactors.
Most animal studies show low to moderate acute toxicity, but repeat dosing in rodents brings up questions about organ-specific effects. Regulatory filings point to some mild irritation at higher loads, often showing up in skin patch or eye contact studies. Chronic exposure databases don’t show major red flags, yet labs treat this compound with respect, sticking to modern PPE and required air filtration. Environmental testing points to sluggish biodegradation; wastewater engineers look for ways to break it down more fully before discharge to avoid ecosystem buildup. Scientists push for better long-term studies, as industrial volumes rise and exposure grows more widespread.
More demanding regulations on industrial chemicals give rise to research into safer, cleaner synthesis. Innovations in process design, like continuous flow reactors or catalyst recovery systems, attract attention both for cost savings and reduced emissions. Academic labs eye structure-activity relationships—how tweaks at the cyclohexyl ring shift physical or biological properties. Testing new salts for specialty applications in electronics and sustainable materials hints at where development may head next. As sustainable chemistry matures, N-Cyclohexylsulphamic Acid stands to benefit from better recycling and smarter product stewardship, striking a balance between industrial utility and responsible handling in a changing world.
Staring at a name like N-Cyclohexylsulphamic Acid for the first time, you might picture something straight out of a university lab, guarded behind fume hoods and science jargon. The reality sits closer to everyday products than most people guess. My first brush with this compound came from working at a family-run cleaning supplies distributor. Orders for certain scouring powders listed something that sounded nearly unpronounceable. That turned out to be N-Cyclohexylsulphamic Acid, chosen for how effectively it chased away rust, scratches, and soap scum on ceramic or metal surfaces.
What stands out in the real world is its cleaning power. N-Cyclohexylsulphamic Acid breaks down calcium deposits and limescale that even elbow grease won’t budge. Some factories switch from hydrochloric acid or phosphoric acid to this less volatile acid to protect equipment and extend product shelf life. Chemicals like this keep toilets, tiles, and even swimming pools looking new because they dissolve stubborn mineral build-up. I’ve seen cleaning brands highlight this feature as part of their edge—strong enough to clean industrial boilers, yet less harsh than alternatives that risk corrosive damage or strong odors.
It surprised me to learn N-Cyclohexylsulphamic Acid links with artificial sweeteners. On the production line, it reacts with sodium hydroxide, leading to sodium cyclamate, a common low-calorie sweetener. Cyclamate showed up in everything from tabletop packets to soft drinks across several continents for decades. For those trying to avoid sugar due to diabetes or calorie concerns, its role goes beyond chemistry—impacting daily nutrition and public health by offering an alternative to both sugar and other artificial sweeteners that sometimes taste bitter or have regulatory issues.
Any chemical used in cleaning agents or food processing has to be considered carefully. Agencies worldwide keep a wary eye on production standards and exposure levels. For example, some places limit or ban cyclamate sweeteners due to research on potential health risks. In the world of cleaning, restriction labels and clear safety instructions remain necessary, particularly for households with kids or pets. Having spent time handling product shipments, I remember the extra steps needed for storage—clearly marked barrels, eye-washing stations, gloves—making sure accidents don’t become headlines.
Modern science never stands still, and N-Cyclohexylsulphamic Acid is no exception. Many researchers keep pushing for alternatives or variations with similar cleaning benefits but less environmental impact. Wastewater treatment matters, too, since compounds like these travel from drains to rivers and lakes, possibly harming aquatic life. Companies now experiment with dilution protocols, neutralizing agents, and better packaging to offset risks. People working on the distribution end need to stay up to date, so manufacturers offer better transparency about sourcing and ingredient safety. This helps both businesses and consumers make more informed choices, which I’ve seen drive loyalty among buyers who care about making a safer home.
N-Cyclohexylsulphamic acid isn’t a chemical you stumble across at the grocery store. This compound, often used in specialty industrial processes, brings some real risks if you don’t show it proper respect. I remember handling similar acids early in my lab work—let your guard down, and you’ll pay the price.
Exposure can irritate skin, eyes, and lungs. Proper safety keeps you working instead of sitting in the emergency room. Thinking you can skip a few precautions almost always ends badly and far too often those stories lead directly back to a forgotten glove or an unlabeled bottle.
Gloves aren’t optional. Nitrile ones keep your hands safe, because plain latex doesn’t always hold up. Labs that skimp on glove quality see more accidents, no matter how many signs they post. Safety goggles play the next big role—this acid splashes easily, sometimes even when you barely nudge the container. Common sense says you only get two eyes, so keep them protected. Full lab coats, with cuffs and coverage, stop this acid from hitting your arms or soaking through your clothes.
In some shops I’ve seen folks think dust masks are enough. N-Cyclohexylsulphamic acid powders or tiny particles belong nowhere near your lungs. Only properly rated particulate respirators or well-ventilated spaces give real protection. Don’t shortchange your lungs. Once, an old coworker handled acid in a closed closet to “save time”—he learned the hard way what chest pain and coughing fits feel like.
Clutter and acid don’t mix. Spills happen most often when containers perch on crowded shelves or get handed over busy benches. I got lucky with a small spill years ago—nothing dramatic, but the cleanup took hours because someone mixed acids on a barely cleaned worktable. Regularly wiping benches, routine checks for leaks or corrosion, and immediate spill cleanup should come as naturally as locking the door behind you.
Labeling saves lives. You grab a bottle with a faded label and play chemical roulette. Fresh, waterproof labels with clear writing or printed codes make the difference between safe handling and confusion in a rush. People often move leftovers into smaller bottles without thinking. Take thirty seconds and mark it up—future you will thank you.
Everyone talks about safety showers and eyewash stations, but plenty of folks don’t check that the water flows clean or the path is uncluttered until they need it. About a year ago, an undergrad in my lab had to rush to the eyewash—because we had checked it every week, seconds weren’t wasted. Train everyone, every time someone new shows up. Dry fire drills look silly until you run one for real.
For all the talk about acids and risk, keeping MSDS sheets handy makes a major difference. I’ve kept old printed ones in a binder and bookmarked the digital versions. Quick access means no one guesses during an emergency. If something goes wrong, you want clear steps in front of you, not a scavenger hunt through old emails.
Many of these practices come down to routine, not high-tech gear or expensive upgrades. Respect the chemical, respect yourself, and look out for coworkers. Don’t trust luck or cut corners—your health and job both depend on these small habits done right every day.
N-Cyclohexylsulphamic Acid brings together a cyclohexyl ring and a sulphamic acid group. The chemical formula appears as C6H11NHSO3H. Each part of this molecule has a job. The cyclohexyl ring delivers some backbone and stability. The sulphamic acid group gives the compound its acid characteristics and reactivity. Looking through safety data sheets and trusted chemical registries backs this up, showing the same structure and formula across the board.
Visualizing N-Cyclohexylsulphamic Acid helps explain its role in science and industry. Cyclohexane, with six carbon atoms making up a ring, bonds with a sulphamic acid group attached at the nitrogen. The full structure wraps up as:
This gives us the full chemical name: N-Cyclohexylsulfamic acid, which lines up with common shorthand: Cyclamate. The molecular structure shows a classic amino group (NH) bridging the cyclohexyl group to a sulfonic acid (SO3H).
Looking at experience with food science, N-Cyclohexylsulphamic Acid sits at the heart of artificial sweeteners. As "cyclamate" in consumer products, it helped introduce low-calorie sweetness in sodas and tabletop packets. Its structure makes it stable under normal kitchen and industrial conditions, so it won’t break down easily in hot coffee or acidic recipes. Professional sources, ranging from food safety authorities to pharmaceutical guidelines, have confirmed its average safety in controlled quantities in many regions.
The sulphamic acid part of the molecule plays a bigger role than just chemistry. This group interacts with taste receptors, creating a sweet sensation without actual sugar. Some chemists would call this molecule robust — not just because it doesn’t caramelize or turn bitter, but because it stays intact when mixed or heated.
Having studied food chemistry, I saw cyclamates get attention for possible health impacts. Regulatory agencies such as the FDA restricted its use in the United States years ago after some early animal studies suggested links to cancer at high doses — levels nobody realistically reaches by eating. The concern centered on metabolism of cyclamate to cyclohexylamine in the gut, which in very high doses showed possible hazards.
Europe, Canada, the UK, and Asia reviewed more data later and allowed its use, assigning safe daily intake levels. That experience raises a key point: Chemicals can switch from concern to widespread acceptance as new evidence comes in. This always reminds me how much context and updated research matter in evaluating health questions.
Instead of completely removing N-Cyclohexylsulphamic Acid from the market, public health experts and scientists settled on clear labeling and well-tested intake thresholds. Science has a chance to respond to real-world use with vigilance, regular research, and honest reporting. This approach helps avoid panic while providing genuine safety.
Every compound, from vitamins to food additives, gets regular reviews to match up with new studies. That steady, careful work creates space for trust in what’s added to food. As for N-Cyclohexylsulphamic Acid, its simple structure and predictable chemistry still spark interest for industry — and lots of debate among doctors, researchers, and families shopping for groceries.
Anyone working with chemicals knows the importance of proper storage. N-Cyclohexylsulphamic acid, commonly found in sugar substitutes and industrial cleaning, holds a place on lab shelves all over the world. While it might sound harmless, once you dive into the chemical’s profile, the need for careful storage becomes clear. It’s a white, odorless solid—but type doesn’t matter as much as what it can do if mishandled. Mishaps around strong acids and synthetic compounds have taught me—the less room for error, the better.
Anyone who’s ever stored dry pasta in a damp kitchen cupboard gets the picture: moisture spells trouble. N-Cyclohexylsulphamic acid reacts badly with water and high humidity. Leave a container open on a muggy summer day and you’ll see clumping and possible breakdown. Excess moisture doesn’t just affect appearance, it prompts chemical changes that can mean unpredictable reactions down the line. Airtight containers—preferably made out of high-density polyethylene or glass—head off headaches by sealing out moisture from the start.
I’ve seen accidents happen simply because a chemical got left by a sunny window. Elevated temperatures and direct sunlight can speed up decomposition and trigger unpleasant byproducts. With N-Cyclohexylsulphamic acid, the rules aren’t different. Stick with a cool, dark space, ideally well below room temperature. Basements with controlled environments do the trick, as do special chemical refrigerators if you’re working in a bigger facility.
People sometimes get lucky tossing everything on one shelf, but relying on luck means inviting disaster. N-Cyclohexylsulphamic acid doesn’t play well with strong bases, oxidizing agents, or chlorinated compounds. All it takes is a splash from the wrong bottle or leaky cap and you’re dealing with harmful fumes or more serious issues. Separation of chemicals by clear labeling and distance works far better than hasty decisions in the moment.
There’s a reason every training session starts with an emphasis on labeling. A clear, unambiguous label tells you what you’re dealing with at a glance. I’ve personally seen averted mix-ups because one person took the extra fifteen seconds to label their jar properly. For N-Cyclohexylsulphamic acid, indicate both chemical name and known hazards. Add the date received and opened, so you know how long it’s been sitting around.
Gloves, goggles, and good ventilation aren’t just for labs. Small operators—bakeries using the acid as a food additive, for example—benefit from routine glove use and keeping a spill kit at hand. Accidents rarely announce themselves. A simple acid spill can escalate without gloves or an emergency eye-wash station nearby. OSHA guidelines exist for good reason, and following those keeps everyone at the bench, and off the injury list.
Chemicals keep things running, but safety steps keep people working. Staff should get regular training, focusing on practical, hands-on practice instead of just theory. Rotate your stock, don’t over-order, and make inspections part of every week. Some companies use color-coded systems or digital inventory tracking to catch mistakes before they grow. In short, close attention and taking ownership build a safer workplace.
N-Cyclohexylsulphamic acid isn’t a compound most folks encounter outside a lab or a specialty plant. It’s got its uses, mainly as a sweetener or additive, and sometimes in industrial processes. The question comes up often: can it truly dissolve in water, or will it need something stronger? Getting accurate data matters, especially for anyone working in research, production, or environmental handling.
This compound, often found in the world of artificial sweeteners under the umbrella of cyclamates, mixes with water to a limited degree. Reports show a range, but the consensus points to modest solubility. Literature states about 1–2 grams will dissolve in 100 milliliters of water at room temperature. That’s not as high as some salts, not as stubborn as oils. In the real world, you end up with a cloudy solution if the ratio tips too far.
I once tried dissolving a batch of cyclamate salt, and it took some stirring—but it did eventually blend, just with a bit of residual cloudiness. Not visually perfect, but enough for testing sweetness and stability as a food additive.
Water isn’t the only game in town. Labs often use methanol, ethanol, or acetone to get things moving. N-Cyclohexylsulphamic acid tends to dissolve more readily in these organic solvents. This opens up possibilities for analysis, extraction, or even production processes where water alone doesn’t do the trick.
Choosing the right solvent brings safety, cost, and downstream processing into play. Ethanol offers a friendlier profile for food-related applications, while acetone gets used in non-edible contexts. One researcher in the field shared that his team leaned on methanol for analytical procedures because results came faster and cleaner.
Whether you’re dealing with chemical production, environmental monitoring, or food formulation, solubility isn’t just a technical footnote. It shapes how much of a substance ends up in a product, what cleanup requires, and what happens if the compound enters the soil or water supply. For example, limited water solubility means cyclamates don’t spread as quickly in the environment as highly soluble salts, but also complicates wastewater treatment or residue cleanup.
Food scientists need accurate data to avoid overloading mixtures, risking precipitation or uneven taste. Regulatory agencies check solubility figures for environmental impact statements, especially with widespread food additives.
Not every source agrees on the details. Some chemical supply catalogs exaggerate solubility for marketing, while some outdated resources offer numbers from early test methods. A solid approach uses peer-reviewed journals or databases like PubChem and ChemSpider, where transparency rules. For a lab or business relying on precise formulation, nothing replaces hands-on tests: weigh, stir, record, and compare.
Solubility affects handling, disposal, and downstream use. For most users of N-Cyclohexylsulphamic acid, understanding its real-world dissolution sets the stage for safe, effective, and responsible application. As more ingredients and industrial substances work their way into daily life, the focus on actual handling conditions, peer-reviewed data, and practical experience only grows more important.
| Names | |
| Preferred IUPAC name | N-cyclohexylsulfamoylamide |
| Other names |
CSA Cyclamate Cyclohexylsulfamic acid E952 Sodium cyclamate |
| Pronunciation | /ɛn-saɪ.kloʊˈhɛk.sɪlˌsʌlˈfeɪ.mɪk ˈæs.ɪd/ |
| Identifiers | |
| CAS Number | 100-88-9 |
| Beilstein Reference | 117186 |
| ChEBI | CHEBI:40261 |
| ChEMBL | CHEMBL3180490 |
| ChemSpider | 13353 |
| DrugBank | DB13751 |
| ECHA InfoCard | 100.011.755 |
| EC Number | 236-080-2 |
| Gmelin Reference | 9195 |
| KEGG | C18709 |
| MeSH | D003581 |
| PubChem CID | 8599 |
| RTECS number | WO7175000 |
| UNII | F39BP1S1TI |
| UN number | UN2585 |
| CompTox Dashboard (EPA) | DTXSID5022518 |
| Properties | |
| Chemical formula | C6H13NO3S |
| Molar mass | 207.28 g/mol |
| Appearance | White crystalline powder |
| Odor | Odorless |
| Density | 1.3 g/cm³ |
| Solubility in water | soluble |
| log P | -0.18 |
| Vapor pressure | Negligible |
| Acidity (pKa) | 1.2 |
| Basicity (pKb) | 7.45 |
| Magnetic susceptibility (χ) | -57.7·10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.573 |
| Dipole moment | 7.03 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 247 J K⁻¹ mol⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | –675.8 kJ mol⁻¹ |
| Std enthalpy of combustion (ΔcH⦵298) | -926.8 kJ·mol⁻¹ |
| Pharmacology | |
| ATC code | A16AX13 |
| Hazards | |
| Main hazards | Harmful if swallowed. Causes serious eye damage. Causes skin irritation. |
| GHS labelling | GHS07, GHS05 |
| Pictograms | GHS05,GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H315, H318 |
| Precautionary statements | H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled. |
| NFPA 704 (fire diamond) | 2-0-0 |
| Flash point | > 189.7 °C |
| Autoignition temperature | > 380 °C |
| Explosive limits | Not explosive |
| Lethal dose or concentration | LD50 (oral, rat): 2600 mg/kg |
| LD50 (median dose) | LD50 (median dose): Rat oral 2 g/kg |
| NIOSH | RN8227 |
| PEL (Permissible) | PEL (Permissible) of N-Cyclohexylsulphamic Acid: Not established |
| REL (Recommended) | 0.5 mg/m3 |
| Related compounds | |
| Related compounds |
Sulphamic acid N-Ethylsulphamic acid N-Propylsulphamic acid N-Cyclopentylsulphamic acid N-Phenylsulphamic acid |
