Product Name: Methyl Methanesulphonate
Synonyms: MMS, Methanesulfonic acid methyl ester
CAS Number: 66-27-3
Molecular Formula: C2H6O3S
Molecular Weight: 110.13 g/mol
Recommended Use: Laboratory reagent, research chemical
Supplier: Data available on chemical packaging or supply documentation
Emergency Contact: National Poisons Information Service, local or industrial safety office phone number
Hazard Classification: Acute toxicity (oral, dermal, inhalation), skin corrosion/irritation, serious eye damage, mutagenicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed, inhaled, or in contact with skin; Causes severe skin burns and eye damage; May cause genetic defects
Pictograms: Corrosive, Acute toxicity, Health hazard
Precautionary Statements: Avoid all unnecessary exposure, wear protective gear, do not eat or drink during use
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms of Exposure: Sore throat, headache, abdominal pain, nausea, vomiting, burns
Chemical Identity: Methyl Methanesulphonate
CAS: 66-27-3
Concentration: Greater than 98% pure
Impurities: Minor unknown impurities may be present, typical of laboratory grade substances
Inhalation: Remove victim to fresh air, keep at rest, provide artificial respiration if not breathing, seek medical attention promptly
Skin Contact: Remove any contaminated clothing, immediately wash skin with plenty of soap and water for minimum of 15 minutes, do not reuse clothing until laundered
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, continue rinsing, get medical attention immediately
Ingestion: Never attempt to induce vomiting, rinse mouth thoroughly, give water only if victim is conscious, seek immediate medical attention
Suitable Extinguishing Media: Carbon dioxide, foam, dry chemical, or water spray
Specific Hazards: Toxic, corrosive fumes of sulfur oxides, carbon oxides, and methyl compounds may form
Protective Equipment: Wear self-contained breathing apparatus, full protective clothing
Other Information: Cool fire-exposed containers with water spray, keep run-off water out of drains and sewers
Personal Precautions: Evacuate personnel, don personal protective equipment, avoid breathing vapors
Environmental Precautions: Prevent further leakage or spillage if safe to do so, keep out of waterways
Methods for Cleanup: Absorb spilled material with inert absorbent, collect and place in tightly closed chemical waste container, ventilate area
Decontamination: Wash area with dilute sodium bicarbonate followed by soap and water
Reporting: Notify relevant safety and environmental authorities in event of significant release
Handling: Wear appropriate gloves, goggles, and lab coat, handle inside fume hood, avoid unnecessary contact, keep away from food, drinks, and smoking materials, use only with adequate ventilation
Storage: Store in tightly closed, chemical-resistant containers away from heat, sparks, open flame, or incompatible chemicals, keep in a cool, dry, well-ventilated area, restrict access to trained personnel only
Incompatible Materials: Strong bases, strong oxidizing agents, nucleophilic reagents
Other Guidance: Segregate from acids and substances subject to nucleophilic attack, monitor for leaks or damage regularly
Occupational Exposure Limits: No occupational exposure limit set for this compound; minimize exposure to lowest practical level
Engineering Controls: Use chemically resistant hood, negative pressure containment, eyewash stations, and safety showers
Personal Protection Equipment: Chemical splash goggles, nitrile or neoprene gloves, impervious lab coat, respirator if risk of inhalation
Hygiene Measures: Wash hands thoroughly after use, do not eat or drink in chemical handling area, remove contaminated clothing immediately
Appearance: Colorless to pale yellow liquid
Odor: Pungent
pH: Not applicable (substance is not supplied in solution)
Melting Point: -30 °C
Boiling Point: 151 °C
Flash Point: 71 °C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable under specific conditions
Vapor Pressure: 2 mmHg at 25 °C
Relative Density: 1.33 g/cm³
Solubility: Soluble in water, ethanol, and many organic solvents
Partition Coefficient: log Kow -0.04
Autoignition Temperature: Data not available
Decomposition Temperature: Data not available
Viscosity: Not determined
Chemical Stability: Stable under recommended storage condition, sensitive to moisture and decomposition at elevated temperatures
Conditions to Avoid: Exposure to moisture, heat, ignition sources
Incompatible Materials: Strong bases, strong oxidizers, nucleophiles
Hazardous Decomposition Products: Methanesulfonic acid, methyl alcohol, sulfur dioxide, carbon oxides
Polymerization: Will not occur under normal conditions
Acute Toxicity: Highly toxic by oral, dermal, and inhalation routes; animal studies indicate LD50 (oral, rat) less than 50 mg/kg
Skin Corrosion/Irritation: Causes severe damage to skin
Eye Damage/Irritation: Causes irreversible injury to eyes
Respiratory Sensitization: Inhalation exposure may result in severe respiratory tract irritation
Germ Cell Mutagenicity: Mutagenic in both in vitro and in vivo assay systems
Carcinogenicity: Not listed by IARC, NTP, or OSHA, but mutagenicity data suggests possible risk
Reproductive Toxicity: Has not been evaluated for reproductive toxic effects
Specific Target Organ Toxicity: May affect liver, kidneys upon repeated or prolonged exposure
Aquatic Toxicity: Harmful to aquatic organisms, data indicate acute toxicity in fish and daphnids
Persistence and Degradability: May undergo slow hydrolysis in water
Bioaccumulative Potential: Unlikely to bioaccumulate due to low log Kow
Mobility in Soil: Expected to be mobile due to water solubility
Other Adverse Effects: No data on ozone depletion or other long-term environmental impact
Recommended Disposal Methods: Incinerate in approved chemical incinerator with afterburner and scrubber
Contaminated Packaging: Dispose containers by puncturing or crushing then send to appropriate waste facility
Local Regulations: Follow all federal, state, and local chemical waste regulations
Special Precautions: Avoid release to environment, do not dispose of down the drain
UN Number: 3277
UN Proper Shipping Name: Methyl methanesulfonate
Hazard Class: 6.1 (Toxic substances)
Packing Group: I
Marine Pollutant: No
Special Transport Notes: Provide full documentation, use appropriate hazard labeling, carry in leak-proof containers, keep separate from food and feedstuffs
OSHA Hazard Communication Status: Hazardous chemical
TSCA Inventory: Listed
SARA Title III (Sections 302/304/311/312/313): Not listed, but handled as extremely hazardous
EU Regulation (REACH): Registration may be required
Other International Regulations: Subject to applicable workplace controls and environmental rules in country of use
WHMIS Classification (Canada): D1A, E — Very toxic material, corrosive material
