Product Name: Ethanesulfonic Acid Ethyl Ester (Ethyl Ethanesulfonate)
Chemical Formula: C4H10O3S
CAS Number: 4394-85-8
Synonyms: Ethyl ethanesulfonate, EES, Ethanessulfonic acid ethyl ester
Recommended Use: Laboratory chemical, intermediate, alkylating agent for various organic synthesis
Manufacturer Information: Supplier details, address, phone number, emergency contact available on invoice or SDS primary page
Emergency Contact Number: Reaches local poison control or company chemical safety hotline
GHS Classification: Acute Toxicity – Oral (Category 3), Acute Toxicity – Dermal (Category 3), Skin Corrosion/Irritation (Category 2), Serious Eye Damage/Irritation (Category 2A), Germ Cell Mutagenicity (Category 1B), Carcinogenicity (Category 2)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, in contact with skin, or inhaled; Causes skin and serious eye irritation; Suspected of causing cancer; May cause genetic defects
Pictograms: Skull and crossbones, exclamation mark, health hazard
Precautionary Statements: Do not handle without protective gloves, goggles, face shield, and properly fitted respirator; Avoid all contact with skin, eyes, and clothing; Keep containers tightly shut and well-ventilated; Wash thoroughly after handling; Do not eat, drink, or smoke during use; Avoid breathing dust, vapor, or mist
Chemical Name: Ethyl Ethanesulfonate
Concentration: ≥99% (by weight)
Impurities: Trace alkanesulfonates, residual ethanol, moisture less than 0.5%
CAS Number: 4394-85-8
Molecular Weight: 138.19 g/mol
Inhalation: Move exposed person to fresh air immediately; keep warm and at rest; seek medical attention if symptoms like coughing, shortness of breath, or dizziness occur
Skin Contact: Remove contaminated clothing and rinse skin thoroughly with plenty of water and gentle soap for at least 15 minutes; if irritation persists, consult medical personnel
Eye Contact: Rinse cautiously with water for at least 20 minutes, keeping eyelids apart and remove contact lenses if present; immediate ophthalmologic attention is needed
Ingestion: Rinse mouth with water if conscious; do not induce vomiting; give small amount of water to drink; obtain urgent medical help
Most Important Symptoms: Burning sensation, headache, nausea, skin redness, respiratory distress
Notes to Physician: Symptomatic and supportive treatment, monitor for delayed respiratory symptoms
Extinguishing Media: Water spray, dry chemical, alcohol-resistant foam, carbon dioxide
Specific Hazards: Emits toxic fumes of sulfur oxides and carbon oxides during combustion; can produce irritating gaseous byproducts at high temperature
Advice for Firefighters: Full protective suit, self-contained breathing apparatus; evacuate area; do not inhale combustion gases
Special Procedures: Cool closed containers near fire with water spray; prevent runoff from entering water bodies or drains
Personal Precautions: Wear full chemical-resistant gear including gloves, respiratory protection, goggles, and coverall; remove all ignition sources
Environmental Precautions: Prevent spill from entering drains, sewers, or surface water; notify environmental authorities in case of major spillage
Containment Methods: Use absorbent materials like earth, sand, or vermiculite; collect and transfer to secure waste container
Clean-Up Procedures: Ventilate area; wash spill site after removal of material; dispose according to regulatory procedure; decontaminate tools and PPE
Handling: Use only in a chemical fume hood or well-ventilated area; avoid airborne dust and vapor exposure; always ground equipment when transferring material
Hygiene Measures: Wash hands, face, and exposed skin thoroughly after handling; no eating, drinking, or smoking in work area
Storage Conditions: Store in tightly closed container in cool, dry, and well-ventilated place; segregate from oxidizers, acids, alkalis, and foodstuffs
Incompatibilities: Strong bases, strong acids, oxidizing agents
Storage Temperature: Recommended below 25°C; protect from heat and moisture
Packaging Materials: Use glass or HDPE containers resistant to chemical attack
Exposure Limits: No established occupational exposure limit; minimize all exposure possible
Engineering Controls: Laboratory fume hood, safety shower, eye-wash station, local exhaust ventilation
Personal Protective Equipment: Butyl or nitrile gloves, chemical splash goggles, lab coat or coverall, respiratory protection (N95 minimum, PAPR for bulk handling)
Hygiene Considerations: Change gloves and lab coat frequently; do not reuse contaminated PPE; decontaminate surfaces before and after use
Environmental Controls: Closed-system operations, vapor extraction when possible, spill containment, safe chemical waste management
Appearance: Colorless to pale yellow liquid
Odor: Faint, sweet, ether-like scent
Odor Threshold: Not established
pH: Not applicable (neat liquid)
Melting Point: -40°C
Boiling Point: 197-199°C
Flash Point: 83°C (closed cup)
Evaporation Rate: Not determined
Flammability: May form flammable vapor-air mixture at elevated temperature
Vapor Density: 4.8 (air = 1)
Vapor Pressure: 0.13 mmHg at 25°C
Solubility: Slightly soluble in water, miscible with most organic solvents
Density: 1.151 g/cm3 at 20°C
Partition Coefficient (log Kow): 0.13 (estimated)
Auto-ignition Temperature: Not determined
Decomposition Temperature: 220°C (releases toxic fumes)
Viscosity: Not established
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Reactive with strong acids, bases, and oxidizers; sensitive to moisture
Hazardous Reactions: May react violently with acid chlorides, alkali metals, reducing agents
Conditions to Avoid: Heat, flames, static discharge, direct sunlight, humidity
Hazardous Decomposition Products: Sulfur oxides, carbon oxides, ethene, ethyl alcohol
Polymerization: Not reported to undergo hazardous polymerization under normal conditions
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: LD50 Oral – rat: 160 mg/kg; LD50 Dermal – rat: 180 mg/kg
Skin Irritation: Severe irritation and redness can result from short contact; likely to cause burns on prolonged exposure
Eye Damage: Risk of permanent damage following contact; immediate washing needed
Respiratory Effects: Vapors may cause difficulty breathing, chest tightness, throat irritation
Mutagenicity: Proven mutagen in animal studies; raises risk of genetic damage
Carcinogenicity: IARC Group 2B (“possibly carcinogenic to humans”)
Sensitization: Can provoke allergic skin response after repeated contact
Target Organs: Liver, kidneys, blood-forming tissues
Chronic Effects: Risk of organ damage from repeated or prolonged exposure; neurological symptoms possible after high-dose exposure
Ecotoxicity: Harmful to aquatic organisms; can cause long-term adverse effects in aquatic environment
Aquatic Toxicity: EC50 (daphnia): 10-50 mg/L (48 hr); LC50 (fish): 30 mg/L (96 hr)
Persistence and Degradability: Moderate persistence in soil and water; slowly hydrolyzes
Bioaccumulative Potential: Not expected to bioaccumulate (log Kow ~0.13)
Mobility in Soil: Mobile; risk of infiltration into groundwater
Other Adverse Effects: Toxic to beneficial soil microorganisms; avoid all uncontrolled disposal or release to environment
Disposal Methods: Dispose via incineration in licensed chemical waste facility; avoid drainage disposal
Container Handling: Rinse containers thoroughly; treat rinse as hazardous chemical waste; puncture and dispose by approved contractor
Waste Code: Consult local, state, and national regulations; likely hazardous under RCRA (U.S.) and similar frameworks internationally
Precautions: Keep away from reactive materials during waste storage and transport; document all disposal actions
Regulations: Comply with governmental and environmental requirements for hazardous waste
UN Number: UN 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (Ethyl Ethanesulfonate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Marine Pollutant: Not specifically listed, but hazardous to aquatic life
Special Precautions: Ensure packaging is secure, correctly labeled, and separated from food or feed; emergency response information in transport documents
Land Transport (ADR/RID): Class 6.1, Toxic substances
Air Transport (IATA/ICAO): Class 6.1, Packing instruction 855
Sea Transport (IMDG): Class 6.1, EmS F-A, S-A
Label Required: Toxic substances (skull and crossbones)
Inventory Listings: Listed or notified under national inventories such as TSCA, EINECS, DSL, AICS, ENCS, KECI, PICCS, NZIoC
EPA Status (U.S.): Designated hazardous substance; subject to risk management under EPA TSCA
EU-REACH Compliance: Registration and compliance required for import and manufacture within EU
OSHA Hazards: Listed as hazardous, requiring full hazard communication program
SARA Title III: Categorized under Section 313; release and storage must be reported
WHMIS (Canada): D1B – Toxic material, D2A – Very toxic material causing other toxic effects
Other Regulations: Operator training, emergency response planning, regular hazard review essential in sites storing, using, or transporting; strong record-keeping and employee health monitoring programs recommended for all workplaces handling this chemical
