Product Name: Aniline-2-Sulfonic Acid
Synonyms: o-Aminobenzenesulfonic Acid, Orthanilic Acid
Chemical Formula: C6H7NO3S
CAS Number: 88-21-1
Molecular Weight: 173.19 g/mol
Recommended Use: dye intermediate, reagent, laboratory chemical
Manufacturer: Refer to supplier details directly for up-to-date contact and emergency information
Contact Numbers for Emergency: Local Poison Control Center or ChemTrec for chemical emergencies and first-aid advice
GHS Classification: Acute toxicity (oral): Category 4, Skin irritation: Category 2, Eye irritation: Category 2A
Hazard Pictograms: Exclamation Mark
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: Avoid breathing dust or fumes. Wear protective gloves and eye protection. Wash hands thoroughly after handling. If in eyes, rinse cautiously with water for several minutes.
Potential Health Effects: Irritation to respiratory tract if inhaled as dust, possible allergic skin reaction, serious discomfort if ingested or exposed to eyes, may cause harmful effects after repeated or prolonged exposure.
Substance: Aniline-2-Sulfonic Acid
Chemical Identity: C6H7NO3S
CAS Number: 88-21-1
Purity: >98% by weight
Impurities: May contain traces of aniline or sulfonic acid derivatives depending on manufacturer purity
Mixture: Not a mixture
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present and easy to do.
Skin Contact: Remove contaminated clothing. Wash affected skin area with soap and water for several minutes. Seek medical attention if irritation persists.
Inhalation: Move person to fresh air. If not breathing, administer artificial respiration and seek immediate medical aid.
Ingestion: Rinse mouth with water. Do not induce vomiting without medical direction. Seek immediate medical help. Give nothing by mouth if unconscious.
Common Symptoms: Redness, itching, burning sensation, coughing, discomfort in the chest, headache, nausea.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or foam.
Unsuitable Media: High volume water jet may spread chemical if large spill occurs.
Hazards from Combustion Products: Emits toxic fumes of nitrogen oxides, sulfur oxides, and carbon monoxide under fire conditions.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Special Procedures: Prevent runoff to sewers or waterways. Use water spray to cool containers exposed to fire.
Personal Precautions: Wear protective gloves, goggles, and NIOSH-approved respirator. Avoid breathing dust. Remove all sources of ignition.
Environmental Precautions: Prevent entry into sewers, surface water, and soil. Notify authorities if a significant spill enters the environment.
Clean Up Methods: Use HEPA vacuum or dampen to avoid dust. Scoop up solid material and place in a suitable sealed container for waste disposal. Wash spill area with detergent and water.
Reference to Other Sections: Refer to handling, disposal, and personal protection guidelines.
Precautions for Safe Handling: Minimize dust generation. Avoid contact with skin, eyes, and clothing. Use only in well-ventilated areas. Clean spills immediately.
Conditions for Safe Storage: Store in tightly sealed containers in a dry, cool, and well-ventilated place, away from incompatible substances such as strong oxidizers.
Incompatible Materials: Strong oxidizers, bases, reducing agents.
Special Handling Advice: Maintain good housekeeping to prevent accumulation of dust and material.
Occupational Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits for Aniline-2-Sulfonic Acid. Keep air levels as low as possible.
Engineering Controls: Use local exhaust or general dilution ventilation. Use safety shower and eyewash station at work area.
Personal Protective Equipment (PPE): Chemical-resistant gloves, safety goggles, protective clothing, and suitable respiratory protection for dusty conditions. Remove contaminated clothing and wash before reuse.
Hygiene Measures: Wash hands thoroughly after handling and before eating or drinking. Do not smoke in work area.
Appearance: White to pale yellow crystalline powder
Odor: Slight, aromatic
Odor Threshold: Not determined
pH (1% solution): About 2 (acidic)
Melting Point: 295–300°C (decomposes)
Boiling Point: Decomposes before boiling
Flash Point: Not applicable (solid)
Evaporation Rate: Not applicable
Flammability: Not flammable in normal handling
Vapor Pressure: Negligible at room temperature
Vapor Density: Not available
Solubility: Soluble in water; slightly soluble in ethanol
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not established
Decomposition Temperature: Over 295°C
Viscosity: Not applicable
Chemical Stability: Stable under normal conditions of storage and use.
Possible Hazardous Reactions: May react with strong oxidizers, reducing agents. Decomposition may release harmful gases.
Conditions to Avoid: Excessive heat, moisture, incompatible substances.
Incompatible Materials: Strong acids, bases, oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, and carbon dioxide.
Acute Toxicity (oral): LD50 (rat): Approx. 1000 mg/kg (literature data)
Skin Corrosion/Irritation: Causes skin irritation on contact
Serious Eye Damage/Eye Irritation: May cause severe irritation, redness, tearing
Respiratory Effects: Dust can irritate the respiratory tract
Skin Sensitization: Not classified as sensitizer, but repeated exposure may induce allergic reactions
Chronic Effects: Long-term exposure may impact blood or cause methemoglobinemia as reported for other aniline compounds
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Mutagenicity: No data for Aniline-2-Sulfonic Acid; other substituted anilines have shown potential in some studies
Reproductive Toxicity: No specific studies available
Ecotoxicity: Harmful to aquatic life based on structure and data from similar chemicals. LC50 (fish, 96 h): data not available for this specific compound, but moderate toxicity expected.
Persistence and Degradability: Expected to have moderate persistence in soil and water; may partially degrade biologically.
Bioaccumulative Potential: Low to moderate based on low octanol-water partition coefficient.
Mobility in Soil: Likely to be mobile in aquatic environments due to water solubility.
Other Adverse Effects: Avoid uncontrolled releases into the environment and surface water.
Waste Treatment Methods: Collect for recycling or disposal via properly permitted chemical waste facilities. Do not dispose of in household garbage or local drains.
Contaminated Packaging: Rinse containers before recycling or disposal. Dispose according to local, regional, and national regulations.
Environmental Precautions: Avoid release to the environment. Consult environmental authorities before discharge.
Disposal Code (US/EU): Check with regional hazardous waste guidance. Handle as hazardous organic chemical.
UN Number: Not regulated for transport under UN Model Regulations
Proper Shipping Name: Not classified as dangerous for transport purposes
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Not listed as marine pollutant
Special Transport Precautions: Keep tightly sealed and protected from physical damage during transport. Avoid breakage or spillage.
TSCA (US): Listed
DSL/NDSL (Canada): Listed or considered compliant
REACH (EU): Registration may be required for industrial uses in accordance with European regulations
OSHA Hazards: Irritant
WHMIS Classification (Canada): D2B - Toxic Material Causing Other Toxic Effects
Inventory Listings: Listed in chemical inventories in major jurisdictions
SARA Title III (US): Not listed as reportable, but user responsibility remains for spill reporting
Other Information: Always follow up-to-date national or local regulations and consult Safety Data Sheet updates from your supplier as regulations can change.
