Product Name: 4-Toluenesulfonic Acid Monohydrate
Synonyms: p-Toluenesulfonic Acid Monohydrate, Tosylic Acid Monohydrate
Chemical Formula: C7H8SO3·H2O
CAS Number: 6192-52-5
EC Number: 204-034-2
Uses: Catalyst in organic synthesis, Pharma intermediate, Polymer production, Laboratory reagent
Manufacturer Contact: Reference product packaging or procurement documentation
Emergency Telephone: Refer to local regulations or supplier emergency numbers
GHS Classification: Corrosive to metals (Category 1), Skin corrosion (Category 1B), Serious eye damage (Category 1)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, May be corrosive to metals
Pictograms: Corrosion
Other Risks: Dust may cause respiratory irritation, Prolonged exposure aggravates skin and eye effects
Precautionary Statements: Wear protective gloves, eye protection, and face protection, Avoid breathing dust or fumes, In case of inadequate ventilation use respiratory protection
Chemical Name: 4-Toluenesulfonic Acid Monohydrate
CAS Number: 6192-52-5
Percentage: 98–100%
Impurities Contributing to Hazard: None known at standard concentrations
Inhalation: Move to fresh air, maintain breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin under running water for at least 15 minutes, seek medical aid for severe burns
Eye Contact: Rinse eyes immediately with plenty of water keeping eyelids open for at least 15 minutes, seek immediate medical attention
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical care
Most Important Symptoms: Severe burns, pain, redness, blurred vision, respiratory distress
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray
Unsuitable Media: Direct water jet onto product
Specific Hazards: Releases toxic fumes of sulfur oxides and toluene under fire conditions
Protective Equipment for Firefighters: Self-contained breathing apparatus, chemical resistant suit, full protective gear
Firefighting Advice: Use water spray to cool containers, evacuate area as needed, contain runoff
Personal Precautions: Wear full protective clothing, including gloves and eye/face protection
Environmental Precautions: Prevent entry to sewers and natural waters
Methods for Clean-up: Absorb with inert material (sand, vermiculite), transfer to a covered disposal container, ventilate area, wash residues with copious water
Spill Reporting: Follow local regulations for notification
Precautions for Safe Handling: Avoid skin and eye contact, prevent formation of dust, use only in well-ventilated areas, keep containers tightly sealed
Storage Requirements: Store in cool, dry, well-ventilated place, away from incompatible materials (bases, oxidizing agents), protect from moisture and direct sunlight, use corrosion-resistant packaging
Hygiene Practices: Wash hands thoroughly after handling, remove contaminated clothing before breaks
Exposure Limits: No established occupational exposure limits for this compound
Engineering Controls: Local exhaust ventilation, emergency eyewash and shower
Personal Protective Equipment:
Respiratory: NIOSH/MSHA-approved respirator for dust,
Eyes: Safety goggles with face shield,
Hands: Chemical-resistant gloves (nitrile or neoprene),
Skin: Full protective clothing
Other Protection Measures: Do not eat, drink or smoke in work area, monitor air concentrations in confined spaces
Appearance: White to off-white crystalline powder
Odor: Faint, characteristic aromatic
Odor Threshold: Not available
pH (1% solution): ≈ 1.0
Melting Point: 103–106 °C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not volatile
Explosive Limits: Not applicable
Vapor Pressure: Not significant at room temperature
Vapor Density: Not determined
Solubility: Soluble in water and alcohol
Partition Coefficient (log Kow): Not determined
Decomposition Temperature: >106 °C
Viscosity: Not applicable (solid)
Bulk Density: Approx. 1.24 g/cm³
Chemical Stability: Stable under recommended handling and storage conditions
Conditions to Avoid: Heat, moisture, direct sunlight, sources of ignition
Incompatible Materials: Strong bases, strong oxidizers, reducing agents, reactive metals
Hazardous Decomposition Products: Sulfur oxides (SOx), toluene, irritating fumes
Possibility of Hazardous Reactions: Violent reaction with bases, can cause corrosion to metals
Acute Toxicity: Oral LD50 (rat) approx. 2,480 mg/kg
Inhalation: Dust may cause irritation of respiratory tract, coughing, and discomfort
Skin Corrosion/Irritation: Causes severe skin burns
Serious Eye Damage/Irritation: Causes permanent eye damage
Respiratory Sensitization: Not documented
Skin Sensitization: Not documented
Chronic Effects: Prolonged or repeated exposure may worsen skin or eye injury
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified as carcinogen, mutagen, or reproductive toxicant by IARC, OSHA, NTP, or the EU
Aquatic Toxicity: Expected to be toxic to aquatic life at high concentrations, limited data available
Persistence and Degradability: Readily biodegradable, breaks down in presence of water and microorganisms
Bioaccumulation: Low potential for bioaccumulation based on structure and water solubility
Mobility in Soil: Soluble and mobile in water, may leach into groundwater
Other Adverse Effects: Not expected to be ozone depleting or significantly harm the environment in small, controlled releases
Waste Disposal: Handle as hazardous waste, dispose according to state and federal regulations
Contaminated Packaging: Rinse thoroughly, treat rinseate as hazardous waste, send for incineration or approved chemical landfilling
Other Disposal Recommendations: Do not dispose via sewage system; coordinate with licensed hazardous waste contractor
UN Number: 2585
UN Proper Shipping Name: p-Toluenesulfonic Acid with not less than 1% water
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: III
Marine Pollutant: No
Special Precautions: Keep container upright and secure, avoid spillage during transport, ensure clear labeling
Regulatory Information for Transport: Complies with ADR, IMDG, IATA transport regulations
U.S. TSCA: Listed
EU REACH: Registered
OSHA Hazard Communication: Classified as hazardous
WHMIS (Canada): Class E: Corrosive Material
SARA Title III: Not listed under Sections 302, 304, 313
California Prop 65: Not listed
Other International Inventories: Included on AICS (Australia), DSL (Canada), ENCS (Japan), EINECS (EU)
Labeling Requirements: GHS compliant, includes hazard pictograms and precautionary statements
