Product Name: 4-(2-Hydroxyethyl)-1-Piperazinepropanesulphonic Acid
Synonyms: HEPPS, EPPS
Chemical Formula: C9H20N2O4S
CAS Number: 16052-06-5
Recommended Use: Biological buffer, laboratory chemical
Company Contact: Emergency phone lines, local suppliers, and distributor details commonly available from sourcing documents and purchase records.
Classification: Not classified as hazardous according to current standards for non-explosive, non-flammable solid laboratory substances
Potential Health Effects: May cause mild skin or eye irritation with prolonged exposure, not considered acutely toxic; inhalation of dust can cause respiratory irritation
Label Elements: No symbol or pictogram required under normal conditions; precautionary statements for dust
Hazard Statements: Exposure may lead to discomfort in the throat, nose, or eyes; persons with known sensitivities should limit dust contact.
Precautionary Statements: Wear protective clothing, avoid inhaling dust, wash thoroughly after handling, keep away from food and beverages during laboratory use.
Chemical Identity: 4-(2-Hydroxyethyl)-1-Piperazinepropanesulphonic Acid
Purity: Greater than 98% (as often sourced for laboratory use)
Impurities: Trace levels of related piperazine or sulfonic acid derivatives may be present depending on supplier, but these typically do not change substance behavior or hazard profile.
EC Number: 240-261-3
Molecular Weight: 252.33 g/mol
Inhalation: Remove individual from contaminated area, seek fresh air, support breathing; medical attention if respiratory difficulty remains after exposure
Skin Contact: Wash with mild soap and water, remove contaminated clothing, seek medical advice if irritation persists
Eye Contact: Rinse immediately with plenty of water, lifting eyelids; check vision with medical provider if symptoms remain
Ingestion: Rinse mouth with water, do not induce vomiting, seek professional evaluation if large quantities are swallowed or if discomfort continues.
Suitable Extinguishing Media: Use water spray, foam, dry chemical or carbon dioxide for fires in surrounding area
Specific Hazards: No significant risk of combustion, non-flammable solid; thermal decomposition can release harmful gases including nitrogen oxides and sulfur oxides
Protective Equipment: Firefighters should use approved self-contained breathing apparatus and full protective clothing for significant fires
Advice: Avoid inhaling combusted fumes; cool containers exposed to heat using water spray.
Personal Precautions: Limit unnecessary contact, ventilate area, wear suitable gloves, safety goggles, and dust mask
Environmental Precautions: Avoid release to drains or surface waters; contain spills using inert material like dry sand
Cleanup Methods: Collect substance in sealable, labeled containers for hazardous waste operations; sweep or shovel carefully to avoid dust generation.
Decontamination: Rinse area with plenty of water once major residue has been removed, check for complete removal using suitable laboratory reagents if needed.
Handling: Operate in well-ventilated space, avoid generating dust, wear clean laboratory gloves and safety eyewear
Storage: Store in tightly closed containers, keep in a cool, dry, well-ventilated area; separate from incompatible substances such as oxidizers; label all containers clearly with product name and hazard information
Hygiene Measures: Clean hands before eating or touching face; avoid mixing with food or drink containers in laboratory environments.
Special Storage Considerations: Do not store above room temperature or in areas subject to high humidity.
Engineering Controls: Use general laboratory exhaust ventilation or fume hood for weighing and mixing
Eye Protection: Wear chemical safety goggles
Skin Protection: Use nitrile, latex or chemical-resistant gloves, wear lab coat
Respiratory Protection: Dust mask or particulate filter respirator if handling significant quantities or if agitation produces airborne powder
Workplace Standards: No established occupational exposure limit; keep exposures as low as reasonably practical, follow institutional safety protocols
Appearance: White to off-white crystalline powder
Odor: Odorless
pH (1% solution): Typically between 7.6 and 8.2
Melting Point: Range from 195 to 205 °C (decomposition may start)
Boiling Point: Not volatile; decomposition prior to boiling
Solubility: Easily soluble in water
Density: Approximately 1.3 g/cm³
Vapor Pressure: Negligible
Partition Coefficient: No relevant data found for octanol-water
Chemical Stability: Stable at standard temperatures and pressures for laboratory work
Reactivity: Shows compatibility with most laboratory chemicals except strong oxidizers
Hazardous Reactions: Contact with oxidizing agents may lead to rapid or uncontrolled reactions
Decomposition Products: Under excessive heat or strong acid/base, can release nitrogen oxides and sulfur compounds.
Conditions to Avoid: Prolonged high heat, strong acids or bases, and mixing with chemicals known to induce rapid redox reactions.
Likely Routes of Exposure: Skin or eye contact, inhalation of dust, accidental ingestion
Acute Toxicity: Data supports very low acute toxicity, LD50 (oral, rat) estimated at >5000 mg/kg
Symptoms: Mild irritation possible for skin, eyes, or if particles enter respiratory system
Chronic Effects: No known chronic toxic effects described under typical laboratory conditions
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Other Data: No significant adverse health effects from short-term laboratory exposure as described by chemical safety references
Ecotoxicity: Not expected to harm aquatic organisms significantly; lacks high acute toxicity to fish or invertebrates according to available studies
Biodegradability: Likely slow due to sulfonic functional group; long-term persistence not fully described
Bioaccumulation: Not expected to bioaccumulate based on water solubility and structure
Mobility in Soil: High solubility in water could facilitate movement in surface and groundwater
Avoidance Measures: Prevent chemical entry into natural water bodies when disposing or cleaning
Method of Disposal: Collect residue in sealed containers labeled for chemical waste
Recommended Disposal: Use licensed hazardous waste disposal contractor familiar with laboratory chemicals
Do Not Discharge: Avoid direct disposal to municipal sewers or natural water bodies
Regulatory Reference: Follow local, regional, and national environmental regulations for disposal, documentation of hazardous waste turnover supports compliance during inspections
UN Number: None assigned; non-hazardous for transport under normal laboratory packaging
Hazard Class: Not a regulated substance under DOT, IATA, or IMDG
Packing Group: None required
Label Required: None required for most shipments
Special Precautions: Store and ship in closed containers, separated from sources of moisture and oxidizers, use secondary containment to avoid spills during transit when shipping in bulk
TSCA Status: Listed in U.S. TSCA inventory
REACH Registration: Manufacturer or importer handles registration for European regulations
OSHA Status: Not regulated as hazardous
SARA 313: Not subject to reporting
California Prop 65: Not listed
Canadian DSL: Listed
Other National Inventories: Generally registered in major developed markets; check local compliance for import and handling in laboratory settings
