Product Name: 3-Aminopropane-1-sulphonic acid
Synonyms: Homotaurine, Tramiprosate, 1-Propanesulfonic acid, 3-amino-
Chemical Formula: C3H9NO3S
CAS Number: 3687-18-1
Recommended Use: Laboratory use, research and development, neuroprotective agent application
Supplier Details: Please refer to the package label or contact your purchasing department for up-to-date company address, phone number, emergency contact hotline, and responsible persons
Emergency Contact: CHEMTREC (available 24/7 for chemical emergencies and spill support)
REACH Registration Number: Available on request from manufacturer or distributor
GHS Classification: Not classified as a hazardous substance under GHS regulations
Main Hazards: Dust may irritate eyes, skin, or respiratory tract if handled without protection; ingestion may cause mild gastrointestinal upset
Signal Word: No significant hazard identified in normal usage
Precautionary Statements: Wear gloves, avoid inhalation of dust, practice good personal hygiene, prevent contact with eyes
Symptoms of Exposure: Coughing, short-lived eye or skin irritation, mild nausea if ingested
NFPA Rating (scale 0–4): Health: 1, Flammability: 0, Reactivity: 0
Potential Environmental Effects: Small accidental releases do not pose environmental risk in most settings, but spillage in aquatic systems should be minimized
Chemical Name: 3-Aminopropane-1-sulphonic acid
Synonyms: Homotaurine, Aminoethyl methyl sulfonic acid
Molecular Formula: C3H9NO3S
CAS Number: 3687-18-1
Purity: Typically over 98% (w/w) as supplied for laboratory use
Impurities: Water (<1%), trace organics from synthesis, no significant hazardous impurities present
Eye Contact: Rinse eyes thoroughly with plenty of water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical attention if irritation persists
Skin Contact: Wash off with soap and water, remove contaminated clothing, seek medical help if irritation develops
Inhalation: Move to fresh air, keep comfortable for breathing, get medical attention if symptoms occur
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice if discomfort persists
Advice for Physicians: Treat symptomatically based on patient’s condition, product is not expected to cause delayed effects or require specific antidotes
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, or carbon dioxide – use what is appropriate for surrounding materials
Hazards from Combustion: May emit sulfur oxides, nitrogen oxides, and carbon oxides in a fire
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Specific Fire-Fighting Procedures: Cool fire-exposed containers, avoid inhaling smoke, prevent run-off from entering water bodies
Unusual Fire/Explosion Hazards: Product is not flammable or explosive under normal conditions, no unusual sensitivity to static discharge or mechanical impact
Personal Precautions: Avoid dust formation, ventilate area, use personal protective equipment (gloves, eyewear, masks)
Environmental Precautions: Prevent further leakage if safe, avoid discharge to drains, soil, or surface water
Spill Cleanup Methods: Sweep up and place in suitable, labeled containers for disposal, clean surface thoroughly to remove residues
Decontamination: Wash contaminated surfaces with water, ensuring wastewater is collected or neutralized if needed
Emergency Procedures: Alert trained personnel, isolate hazard area if large spill, refer to local emergency plans
Safe Handling Advice: Wear suitable protective clothing, minimize dust generation, avoid breathing dust or contact with skin and eyes, wash hands after handling
Technical Measures: Use local exhaust ventilation or process enclosures to capture dust, keep containers tightly closed
Conditions for Storage: Store in a tightly sealed, labeled container in a dry, cool, well-ventilated place away from incompatible substances (strong oxidizers)
Compatibility: Keep away from moisture, acids, or oxidizing agents
Incompatibilities: Strong acids, strong oxidizers, bases that cause decomposition may release sulfur compounds
Packaging Materials: Use high-quality plastic, glass, or corrosion-resistant containers
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, or NIOSH
Engineering Controls: Provide general room ventilation with local exhaust, especially in bulk handling operations
Personal Protection: Use gloves (preferably nitrile or latex), chemical safety goggles, dust mask or particulate respirator
Hygiene Measures: Wash hands thoroughly after use, remove contaminated clothing, do not eat, drink, or smoke while handling
Respiratory Protection: Wear NIOSH-approved dust mask in case of inadequate ventilation
Skin Protection: Wear standard laboratory coat or long sleeves
Eye/Face Protection: Safety goggles recommended in all laboratory settings
Appearance: White to off-white crystalline powder
Odor: Odorless or very faint characteristic odor
Molecular Weight: 139.18 g/mol
pH: 3.5–5.5 in 20g/L aqueous solution
Melting Point: Decomposes above 300°C
Solubility: Freely soluble in water, insoluble in most organic solvents (chloroform, ether)
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (log Pow): Less than zero (highly hydrophilic)
Density: 1.5–1.65 g/cm³
Flash Point: Not flammable
Auto-Ignition Temperature: Not self-igniting
Chemical Stability: Stable under recommended storage conditions, not reactive at room temperature
Hazardous Reactions: No hazardous polymerization expected, reacts with strong oxidizing agents, acids may generate toxic gases
Incompatible Materials: Avoid strong acids and oxidizers; can decompose especially in presence of moisture and acid
Decomposition Products: Sulfur oxides, nitrogen oxides, carbon dioxide and monoxide
Conditions to Avoid: Excess moisture, excessive heat, exposure to strong acids or oxidizing chemicals
Acute Toxicity: Oral LD50 (rat) >2000 mg/kg, considered low toxicity based on available studies
Inhalation: Dust can irritate respiratory mucosa on prolonged or repeated exposure
Dermal: Not absorbed through intact skin, no hazardous absorption expected
Chronic Exposure: No known adverse effects from chronic low-level exposure in humans or animals at occupational levels
Skin/Eye Irritation: May cause mild, reversible irritation
Sensitization: Not a known skin or respiratory sensitizer
Genotoxicity/Carcinogenicity: No evidence for mutagenic or carcinogenic potential
Reproductive Toxicity: No studies show developmental or reproductive effect in laboratory animals
Ecotoxicity: No data suggest hazard to aquatic or terrestrial organisms at concentrations expected from laboratory or research use
Mobility in Soil: Likely rapidly removed from soil by dissolution in water; not expected to adsorb strongly
Persistence/Degradability: Readily biodegradable in the environment under appropriate conditions
Bioaccumulative Potential: Does not bioaccumulate (low log Pow)
Other Adverse Effects: Spills should not be discharged to surface water, may cause local pH changes if very large quantities are released
Waste Disposal: Dispose by approved chemical waste handler; typically incineration or landfill in accordance with local, regional, or national regulations
Container Disposal: Decontaminate and dispose of containers as regular waste if completely cleaned, otherwise treat as chemical waste
Recycling: Not applicable for most laboratory or research settings
Precautions: Prevent access to drains, sewers, and waterways, minimize generation of waste
EPA Waste Number: Not regulated as hazardous waste under US EPA RCRA
UN Number: Not regulated as a dangerous good
Transport Hazard Class: Not classified as hazardous according to ADR, IMDG, IATA
Packing Group: Not assigned
Label: No transport hazard label required
Special Precautions for Transport: Avoid wetting, use tightly sealed containers to prevent leakage during transport
Environmental Hazards: No evidence for acute aquatic hazard during transport
Transport in Bulk: Not subject to bulk transport requirements
OSHA: Not subject to specific OSHA requirements for hazardous chemicals
TSCA: Listed or exempt under the Toxic Substances Control Act
DSL/NDSL (Canada): Listed
REACH Registration: Manufacturer or importer should provide status and registration details if requested
SARA/EPCRA: Not listed
California Proposition 65: Not regulated
Other Local Regulations: Check applicable state, provincial, or national regulations for chemical hazards, storage, and reporting requirements
International Inventories: Registered in EU, North America, and other major jurisdictions – compliance varies by country
