Product Name: 2-(Perfluorohexyl)ethanesulfonic acid
Synonyms: PFHxES, Perfluorohexylethanesulfonic acid
Chemical Formula: C8H5F13O3S
Molecular Weight: 440.17 g/mol
CAS Number: 27619-97-2
Recommended Use: Research, surfactant applications, laboratory reagent
Manufacturer/Supplier: Contact information as provided by supplier
Emergency Phone: Supplier-dedicated emergency contact
REACH Registration Number: Available upon request from manufacturer/distributor
Global Harmonized System Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Acute aquatic toxicity (Category 1), Chronic aquatic toxicity (Category 1)
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation. Very toxic to aquatic life with long lasting effects. Suspected of causing reproductive toxicity.
Pictograms: Exclamation mark, Environment
Precautionary Statements: Avoid release to environment. Wear protective gloves, eye protection. Wash hands thoroughly after handling.
Potential Health Effects: May cause skin sensitization or respiratory irritation in certain exposure conditions. Accumulation through repeated exposure may affect thyroid and liver function.
Environmental Impact: Persistence in environment; highly bioaccumulative in aquatic organisms due to strong fluorinated carbon bonds.
Chemical Name: 2-(Perfluorohexyl)ethanesulfonic acid
Concentration: 98–100%
Impurities: Minor impurities unlikely, but typically less than 2% (per manufacturer technical sheet)
Other Ingredients: None (single substance product as supplied)
EC Number: 608-158-5
Index Number: Not established
Specific Identifiers: Follows nomenclature standards supported by fluorochemicals and sulfonic acids regulatory bodies
General Advice: Move affected individual out of contaminated area. Ensure fresh air and medical attention without delay.
Inhalation: Remove to fresh air. Seek medical care if symptoms develop or persist.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Get medical advice if irritation develops.
Eye Contact: Rinse cautiously with water for several minutes, lifting lids periodically. Remove contact lenses if present and easy to do. Seek hospital evaluation if redness or pain persists.
Ingestion: Do not induce vomiting. Rinse mouth with water. Call poison control center or a physician immediately.
Symptoms and Effects: Irritation of affected sites (skin, eyes, mucous membranes), nausea or headache (from inhalation), signs of allergic response
Advice for Doctors: Provide symptomatic treatment. Monitor for delayed effects on liver, kidneys, and thyroid.
Suitable Extinguishing Media: Use dry chemical, CO2, alcohol-resistant foam. Water spray for cooling containers only.
Specific Hazards: Toxic fumes containing hydrogen fluoride, sulfur oxides and perfluorinated compounds may develop in fire.
Protective Equipment: Wear full protective gear and self-contained breathing apparatus.
Special Procedures: Approach from upwind; avoid inhaling combustion products. Cool exposed containers with water if safe.
Flammability: Not flammable; decomposition may release hazardous gases.
Combustion Products: Hydrogen fluoride, perfluorinated compounds, SOx gases
Explosion Data: No known explosion hazard.
Personal Precautions: Wear chemical-resistant gloves, goggles, lab coat, and mask as warranted by risk assessment.
Environmental Measures: Prevent product from entering soil, drainage systems, or open waterways.
Cleanup Methods: Absorb liquid spills in approved inert material (e.g., sand or double-layered absorbent pads). Shovel residues into marked containers for disposal. Ventilate area and wash spill site thoroughly.
Special Considerations: Given the persistence and toxicity to aquatic life, use extra care to contain and collect spillages.
Decontamination: Clean contaminated surfaces with appropriate surfactant-based cleaner. Dispose rinse material as hazardous waste.
Handling: Avoid breathing dust, vapor, or mist. Use only in fume hoods or well-ventilated areas. Prevent skin and eye contact. No eating, drinking or smoking in work area.
Storage: Store in original, tightly closed container, kept cool and dry. Place away from incompatible materials. Protect from direct sunlight, heat sources, and freezing temperatures.
Incompatible Materials: Strong bases, strong oxidizers, alkali metals.
Special Storage Instructions: Ensure proper secondary containment to avoid environmental release.
Exposure Limits: No established occupational exposure limits for this compound; refer to local regulations and institutional policies.
Engineering Controls: Use only in chemical fume hood. Provide eyewash station and safety shower in work area.
Personal Protective Equipment: Chemical splash goggles, chemical resistant gloves (nitrile, neoprene), long-sleeved lab coat, closed footwear.
Respiratory Protection: Use suitable respirator if risk of aerosol or vapor exposure exists.
Industrial Hygiene: Wash hands and exposed skin thoroughly after handling. Remove contaminated clothing and launder before reuse.
Environmental Controls: Implement containment to prevent environmental discharge; use waste treatment systems for wash water.
Appearance: Colorless or pale yellow viscous liquid or solid (depending on storage temperature).
Odor: Nearly odorless.
pH (1% Solution): Typically 2–3
Melting Point/Freezing Point: Ranges from 25°C to 37°C
Boiling Point: Decomposes above 180°C, does not boil under standard atmospheric conditions.
Solubility: Water soluble up to 20 g/L at room temperature.
Vapor Pressure: Extremely low
Partition Coefficient (log Kow): Estimated 4.5–6 (highly lipophilic)
Density: 1.7–1.8 g/cm³ at 20°C
Viscosity: High at room temperature
Decomposition Temperature: Above 185°C; releases hazardous vapors
Other Data: Surface active; strongly persistent; negligible evaporation at room temperature
Chemical Stability: Chemically stable at recommended storage conditions.
Conditions to Avoid: Heating above decomposition temperature, exposure to strong alkalis, oxidizers
Incompatible Materials: Strong bases, strong oxidizers, reactive metals
Hazardous Decomposition Products: Hydrogen fluoride, perfluoroalkyl fragments, sulfur oxides
Polymerization: Not known to undergo hazardous polymerization.
Reaction Characteristics: Resistant to hydrolysis and most solvents due to strong carbon-fluorine bonds.
Acute Toxicity Routes: Oral, inhalation, dermal (limited specific data; animal models suggest low acute toxicity in small, single doses)
Skin Corrosion/Irritation: Causes irritation; possible dermatitis on repeated exposure.
Eye Damage/Irritation: Causes local irritation; can lead to conjunctivitis with direct contact.
Respiratory Sensitization: Inhalation of dust or aerosols may trigger coughing or sore throat.
Chronic Effects: Evidence of possible bioaccumulation, potential liver and thyroid toxicity in animal studies.
Carcinogenicity: No official classification, but structural activity raises concerns; certain perfluorinated compounds have shown carcinogenicity in rodents.
Reproductive Toxicity: Data suggest hormonal disruption at sustained exposure.
Mutagenicity/Genotoxicity: Not enough evidence for mutagenic activity.
Other Effects: Persistent organic contaminant properties; long biological half-life in exposed organisms.
Eco-toxicity: Highly toxic to aquatic life (fish, invertebrates, algae). Low observed adverse effect concentration (LOAEC) in chronic studies.
Persistence: Extremely persistent; negligible natural degradation due to perfluorinated chain.
Bioaccumulative Potential: Strong tendency to accumulate in aquatic organisms and potentially in humans ecosystems.
Mobility in Soil: Moderate to high; product travels with groundwater due to weak binding with soil particulates.
Long-Term Impacts: Contributes to perfluoroalkyl substances (PFAS) buildup, known for environmental persistence and difficulty in remediation.
Other Adverse Effects: Chronic contamination of surface, groundwater, and potential for food web magnification.
Waste Treatment Methods: High-temperature incineration with scrubbers recommended for destruction; landfill not preferred due to persistence risk.
Uncleaned Packaging: Rinse containers with compatible solvent and incinerate packaging under controlled conditions.
Special Warnings: Do not discharge to surface water, sewer, or soils.
Regulatory Requirements: Treat as hazardous waste per local, national, and international guidelines for PFAS compounds.
Containment: Capture all process wash water; incinerate or handle as hazardous waste.
UN Number: Not classified under general UN hazardous substances; check with shipping provider for specific designation.
UN Proper Shipping Name: Consult shipping regulations—generally transported as "Environmentally hazardous substance, liquid, N.O.S. (contains perfluorinated compound)"
Transport Hazard Class: Not specifically listed; handle as hazardous due to environmental and irritation hazards.
Packing Group: III (precautionary), if regulated
Marine Pollutant: Yes, per marine shipping rules
Special Precautions: Double containment, clear labelling of environmental hazard, emergency contact on shipping document.
Transport in Bulk: Minimize transfers and accidental releases; consult bulk shipping regulations.
TSCA Status (US): Covered under Toxic Substances Control Act as a PFAS compound.
REACH Registration (EU): Subject to REACH requirements as a persistent, bioaccumulative, and toxic substance; may face restrictions or notification obligations.
Canada DSL/NDSL: Regulated as a PFAS with notification needed for uses.
OSHA Hazard Classification: Irritant, possible reproductive toxin, environmental hazard.
Other Local Regulations: Many jurisdictions restrict emissions or effluents containing PFAS. Consult applicable regulations before use.
SDS Preparation Date: Ensure usage of up-to-date vendor-supplied sheet.
