Chemistry often builds on a history of trial, error, and curiosity. [(2-Methoxyphenyl)Amino]Methanesulphonic acid stepped onto the scene at a time when aromatic amines and sulfonic acids opened pathways for dyes, pharmaceuticals, and agrochemicals. In university labs, folks spent evenings exploring ways to bolt functional groups onto aromatic rings. This process made molecules like this one valuable beyond basic research. During the twentieth century, chemists began investigating the influence of methoxy and amino groups on aromatic compounds. The formation of methanesulphonic acid structures offered a new chapter, providing a combination of water solubility and reactivity once limited to more hazardous sulfonation chemistry.
A bottle of [(2-Methoxyphenyl)Amino]Methanesulphonic acid typically holds a fine powder with a slightly pale shade, sometimes bordering on off-white. Handling this substance, you notice it dissolves readily in water and many polar solvents. Its structure grants it a place in both industrial settings and academic studies, serving as a building block in organic synthesis and specialty chemical processes. Bulk suppliers offer it across multiple purity grades, supporting needs that range from technical manufacturing to analytical reference.
The melting point often lands between 150°C and 160°C, avoiding decomposition in routine heating. A solubility profile skewed toward hydrophilic environments reflects the presence of both sulfonic acid and methoxy groups. The molecular weight stands at around 233 grams per mole. This material holds stability at ambient conditions and shows resistance to hydrolysis under neutral or slightly basic settings. In my lab days, its strong aromatic odor still lingers in memory, standing in contrast to many other, less aromatic sulfonic acids. Handling calls for care because of its reactivity and potential to release fumes if inadvertently heated too far.
Responsible suppliers provide a certificate of analysis showing purity, moisture content, and residual solvent levels. Products often come packed in sealed, moisture-proof containers to avoid clumping or unwanted reactions. Safety data includes hazard codes for irritation, respiratory issues, and environmental persistence. International trade names and synonyms appear on labels for clarity, as global movement of specialty chemicals remains common. Standard labels mention batch number, lot, expiry date, and recommended storage temperature (usually under 25°C in a dry place). Good communication up and down the supply chain means less guesswork for everyone involved.
Preparation starts with 2-methoxyaniline and a controlled sulfonation with methanesulfonic acid—or sometimes with chlorosulfonic acid and methyl ether intermediates, depending on the resources and expertise available. I remember using glassware chilled in an ice bath to control the exothermic nature of this combination. A dropwise addition, constant stirring, and careful monitoring of temperature help avoid runaway reactions. Industrial settings scale up by using jacketed reactors and advanced controls, yet the basic chemistry remains unchanged. The crude product undergoes filtration, washing, and recrystallization to produce a fine, pure output suitable for further research or application.
This acid acts as a starting material for more complex transformations. Chemists use it in diazotization, coupling reactions, and for preparing advanced dyes and pigments. Methoxy substitution on the aromatic ring can direct electrophilic attack, and that knowledge helps in planning synthetic pathways. I have seen its amine group protected and deprotected to allow multi-step organic syntheses, minimizing unwanted byproducts. Experiments using this compound often end with easy purification due to the strong solubility gap between sulfonated products and their byproducts in aqueous and organic phases.
Catalogs and Material Safety Data Sheets list several alternatives, including 2-(Methoxyphenylamino)methanesulfonic acid, 2-Methoxyaniline methanesulfonic acid, and N-(2-Methoxyphenyl)methanesulfonamide. I ran into studies that sometimes abbreviate it according to their laboratory’s in-house shorthand, but the chemical community aligns on its IUPAC structure for regulatory reasons. These multiple names reflect the global span of chemical research and trade.
Routine use involves gloves, goggles, and lab coats, as with most aromatic amines. Direct skin or eye contact causes irritation, so well-ventilated spaces reduce airborne risks. Disposal protocols follow regional hazardous waste regulations because even relatively benign aromatic compounds can persist in water tables or airborne dust. My early mistakes with similar sulfonic acids—a quickly inflamed patch of skin or a coughing fit from a forgotten fume hood—emphasized the importance of consistent safety routines. Facilities with ISO 9001 and similar certifications build checklists and staff training around these hazards to lower incident rates and long-term health concerns.
Dye and pigment synthesis continues to be a dominant use, especially in designing stable, vivid organic colorants. This acid’s structural features offer routes to pharmaceutical intermediates and research into enzyme inhibitors. I’ve come across patents proposing uses in corrosion inhibitors, agrochemical development, and as a tracer in environmental analysis. The sulfonic acid group increases water solubility, supporting applications in aqueous systems or delivering functional groups to proteins or synthetic polymers. Small changes in its structure—swapping substituents or chain length—often mean new applications, with each tweak producing different solubility and reactivity profiles.
New research highlights functional derivatives used as biologically active agents. Academic publications report on modification protocols and reaction pathways, often revealing new shortcuts or yield improvements. I have seen undergraduate projects based on these compounds yield successful graduate careers, as fundamental reactions led to more ambitious medicinal chemistry. Industrial R&D teams keep an eye out for every new article, hoping to spot the next application early. Partnerships between universities and chemical manufacturers help translate new knowledge into scalable, cost-effective production.
Studies on toxicity underscore concerns about chronic exposure to aromatic amines. Animal models and in vitro assays evaluate environmental persistence and breakdown products. These studies often reveal a low acute toxicity, but discrepancies exist among species. Chronic effects tend to draw more attention, especially concerning occupational exposure and aquatic toxicity. We ran standard Ames tests in our lab to monitor mutagenic potential, and while results showed moderate concern at high doses, regulatory agencies continue updating guidance as new evidence surfaces. Companies working with sulfonic acids invest in continuous monitoring and protective equipment, not just to follow regulations, but to keep teams healthy.
The path forward looks busy. With demand for custom dyes, enzyme modulators, and specialty additives growing, this acid and its analogs start appearing in more research portfolios. Digital chemistry tools—machine learning for reaction optimization and computational modeling—speed up discovery and scale-up. Environmental regulations tighten, encouraging greener production routes and improved waste management. Startups look for ways to recycle spent reagents and recover valuable intermediates, shifting the market toward sustainability. The next era lies at the junction of practical synthetic chemistry, materials science, and green engineering, offering both challenges and a sense of responsibility for every hand stirring a beaker of [(2-Methoxyphenyl)Amino]Methanesulphonic acid.
(2-Methoxyphenyl)amino methanesulphonic acid draws attention from chemists for its layered molecular framework. Picture a benzene ring as the backbone. This ring carries a methoxy group at the ortho position, which means the –OCH3 sticks close to the connection point. The twist comes with the amino substitution; an NH group bridges the aromatic system with a methanesulfonic acid chain. In structural terms, think of a methoxy group at carbon 2 of aniline, and the nitrogen attaches to a CH2SO3H arm.
The structure of this molecule tells a story. It combines aromatic chemistry—seen in dyes, pharmaceuticals, and agricultural compounds—with the water-loving properties of sulfonic acids. That sulfonic tail doesn’t just sit there for looks. It matters for solubility, sticking the molecule into water-based environments with stubborn reliability. In the lab, chemicals like this help push reactions forward, sometimes acting as intermediates or even as key players in the development of new drugs or pigments.
Learning about the impact of electron groups on the aromatic ring in college stuck with me. The methoxy group pushes electrons into the ring, which means it can change the way the molecule reacts with acids or oxidizing agents. If you’ve ever worked with anilines, you know they bring their own chemistry—often tying up with diazonium salts to give dyes, or reacting in condensation reactions vital for advanced pharmaceutical work.
Sulfonic acid groups turn a molecule into a more friendly companion for water, which changes toxicity, absorption, and reactivity. Regulatory bodies keep a close watch on sulfonated aromatics, thanks to how easily they slip into groundwater and stay there. This acid group also means (2-Methoxyphenyl)amino methanesulfonic acid won’t evaporate or sneak out of a process unnoticed.
From a technical vantage, that nitrogen bridge means the molecule links the electronic properties of both the aromatic system and the sulfonic chain. Reactivity changes. Stability shifts. Handling transforms—sometimes for the better, sometimes not. This all boils down to how chemists and engineers use the structure to tweak solubility, adjust pH, and create stable, useful end products.
Safe handling of this acid means proper ventilation, gloves, and eye protection. Anyone who’s dealt with sulfonic acids remembers chemical burns or that lingering slippery feeling. The right protocols protect workers, while good chemical waste management keeps these molecules from contaminating waterways.
On the innovation front, research continues to dig into hybrid molecules like this for greener products. Efforts include creating better water treatment compounds and more readily biodegradable dyes, leveraging structural features like the methoxy group and the renown sulfonic acid tail.
Understanding the way these atoms link up gives scientists a chance to build safer, more efficient molecules for medicines, industry, and environmental cleanup. It's not just about drawing pretty structures—it's about using foundational knowledge to solve tough problems.
(2-Methoxyphenyl)amino methanesulphonic acid catches attention in the world of pharmaceutical research. Chemists value its structure because it forms a building block for making new drugs, especially compounds used to manage chronic illnesses. Drug creators look to this molecule when developing candidates for things like antihypertensive or anti-diabetic medicines. It’s about finding scaffolds that bring stability or allow for specific modifications, and this compound offers both. The presence of its methoxy and amino groups gives research teams a way to adjust solubility, improve bioavailability, or tweak chemical behavior to get a drug to its target more reliably. I’ve seen projects stall because a key intermediate couldn’t be fine-tuned, so having molecules like this in the toolkit keeps innovation moving forward.
Lab teams working with dyes and specialty pigments often start with a sulphonated aromatic base. (2-Methoxyphenyl)amino methanesulphonic acid offers strong coloration and stability under heat and light, traits that really matter when producing colorants for textiles or inks. Its unique molecular shape interacts well with other dye precursors, helping manufacturers create materials with better colorfastness or specific hues that hold up even in demanding conditions.
The textile industry in places like India and Bangladesh pays extra for improved wash resistance and environmental compatibility. A few years ago, I watched a small dye house turn to newer sulphonated compounds, seeking a safer, less toxic alternative for worker safety. This acid formed the basis of those improvements, allowing compliance with the REACH standards that have become the de facto global baseline.
Researchers running complex organic syntheses rely on compounds that help them route reactions cleanly. (2-Methoxyphenyl)amino methanesulphonic acid sometimes acts as a coupling partner or protective group. It helps direct chemical transformations, increasing selectivity and controlling side reactions in multi-step syntheses. This matters not just for benchtop curiosity but for scaling up pharmaceutical ingredients. Reliable intermediates save time and materials, which helps keep costs in check for patients and keeps dangerous byproducts to a minimum.
There’s a conversation growing louder in chemical circles: sustainability can’t just be a buzzword. The bulky aromatic compounds and sulphonated derivatives like this one carry risks if released improperly. I recall a case where a downstream plant got hit with fines because trace levels of unused chemicals slipped past wastewater treatment. Manufacturers who use this molecule watch for greener synthesis methods and work on closed-loop systems, recycling streams and scrubbing out contaminants. Responsible sourcing, rigorous waste handling procedures, and green chemistry innovations are key. Transparent data sharing about toxicity and degradation also helps communities living near manufacturing zones stay informed and protected.
Quality assurance isn’t just paperwork. Labs handling complex molecules use regular analytic checks—think HPLC or NMR—to guarantee the exact specifications of sulphonated aromatics. Regulatory frameworks like those outlined by the FDA or ECHA rely on accurate data, so producers keep logs of every batch, monitor purity levels, and test for unexpected impurities. In markets where clinical applications drive demand, strong documentation keeps patients safe, while transparent supply chains reduce the chance of contamination.
Progress in drug discovery, pigment chemistry, and synthetic organic chemistry stems from access to reliable building blocks. (2-Methoxyphenyl)amino methanesulphonic acid keeps showing up on radar for a reason. By paying attention to smart process design and open communication up and down the supply chain, it’s possible to harness the benefits while keeping environmental and health risks in check.
Every chemical formula has a story, and the molecular weight is part of the one for [(2-Methoxyphenyl)Amino]Methanesulphonic Acid. Take a trip through any chemistry lab, you’ll hear people talking about molecular weight as if it’s as obvious as a phone number. Still, that number means something real. Without it, measurements get fuzzy, reactions go off course, and none of your calculations line up.
So why focus on this compound and not just any acid hanging out on a science shelf? This one pulls together a unique set of atoms. You’ve got a methoxy group bonded to a phenyl ring, then a sulfonic acid tag dangling at the other end through a methyl chain. The blend catches attention because tweaks like the methoxy group mess with reactivity and behavior in water.
Chemists lay it out as C8H11NO4S. Some folks might type out the full structure or sketch aromatic rings across a notebook, but really all that matters for molecular weight is counting atoms and matching them to their standard atomic weights:
A little back-of-the-envelope calculation lines up like this:
A number like 217.25 g/mol doesn’t float around without purpose. Step into a real lab and this single number shapes the way solutions get measured, drugs get dosed, or even how pollution gets tracked. Picture researching how molecules like this act as drug candidates or tracing their fate down a wastewater pipe. You need this figure to run chromatography, run titrations, and balance equations that tell you whether a reaction has a chance.
Every field, whether looking at pharmaceuticals, materials, or environmental chemistry, leans on numbers with roots in atomic weights published by folks like IUPAC. Molecular weights end up in databases, safety data sheets, grant proposals, and even the text that gets reviewed by regulatory agencies. If the number is wrong or even off by a decimal, entire experiments tumble or, worse, safety risks slip past unnoticed.
Facts and accuracy shape good science. If you’re calculating dosages for a new medicine or figuring out how a pollutant breaks down, working with solid molecular weights guarantees no one gets shortchanged or misled. Errors in these weights have led to failed syntheses or contaminated products — years ago, I recalculated a solution after catching a molecular weight typo on a colleague’s sheet. That simple correction saved rounds of troubleshooting.
The tools available now—high-resolution mass spectrometers, databases like ChemSpider, online calculators, and peer-reviewed journals—help everyone stick to the numbers. Using trusted resources with strict fact-checking goes a long way in keeping research transparent and reproducible, which builds trust between scientists, healthcare workers, and the folks using these materials every day.
Scientists and lab techs double-check these basics, share correction notices, and keep training fresh. Building a habit of checking source data and updating protocols stops avoidable mistakes. More open access to trusted chemical data matters for education, safety, and progress. A little vigilance at the front end saves massive headaches down the road.
I’ve worked around labs long enough to know that chemical storage gets overlooked far too often. [(2-Methoxyphenyl)Amino]Methanesulphonic Acid, sitting on the shelf, looks harmless at first glance. But curiosity meets common sense: this compound, like many specialized organosulfur acids, deserves respect. Ignoring precautions leads to more than just a spilt beaker — it puts health and research dollars on the line.
I’ll share what experience taught me: temperature and airflow matter. This acid prefers a cool, dry place, away from any source of heat or humidity. High temperatures speed up unwanted reactions, especially with ambient moisture. I watched too many colleagues regret tossing chemicals into any spare cabinet. Letting compounds like this sit near windows, vents, or someplace people often walk by, only invites trouble down the road.
Shelves inside a fume hood work well, provided you label and seal containers tightly. Light can degrade some chemicals faster than you think. An opaque or amber bottle adds an easy layer of defense. If you don’t have commercial-grade cabinets, at least pick the location least exposed to accidental bumps or drops.
Labs lean hard on accuracy. One of the worst missteps happens from careless bottle swaps or traces of the wrong dust. Acids like this don’t play nice with bases, strong oxidizers, or reducing agents. I learned the hard way: keep every acid, especially unfamiliar ones, far from incompatible chemical families. Mixing just a few drops can foul up results or spark reactions you want nowhere near skin or lungs.
Dedicated shelves or bins marked for “acids” aren’t just bureaucratic red tape — they matter. Gloves, closed shoes, and those ugly but effective goggles save eyes and fingers from blisters. Even a single grain on your gloves or tools tracks across the lab — and that bites back when least expected.
Look at chemical safety sheets from trusted sources like the European Chemicals Agency. They say the same thing: keep moisture out, seal the lid, and mind the shelf life. Don’t just put faith in a half-written label from last year. Chemistry moves faster than memory. If that bottle gets cloudy or the cap sticks, treat it as a warning.
I’ve seen better research and stronger teamwork from labs that run monthly checks on storage areas. Someone always catches a crusty cap, fading label, or mystery stain. Tossing out “unknowns” costs less than dealing with ruined experiments or medical bills. Timely restocking and disposal can save budgets and protect reputations too.
Real safety means real habits. If your lab struggles with crowded cabinets, push for investment in flame-resistant or chemical-resistant storage. Clear training policies set the tone for new staff and busy seasons. Safety drills and peer walkthroughs catch habits before they turn into messes. Research thrives best in tidy, well-cared-for spaces, especially where every bottle and acid has a clear place.
Putting effort into safe handling of compounds such as [(2-Methoxyphenyl)Amino]Methanesulphonic Acid isn’t dull routine. It’s what keeps work running smoothly, protects people, and lets science move ahead without interruption.
Every day, folks in labs and workshops come across chemicals with names that stretch across the page. [(2-Methoxyphenyl)Amino]Methanesulphonic Acid might sound like one of those obscure compounds you only read about in textbooks. Still, like any substance cooked up in a lab, it asks for respect—both for what it can do and what it could do if something goes wrong.
Straight up: there’s no cutting corners around the importance of the safety data sheet (SDS). The truth is, many mishaps kick off with someone skipping this simple step. Some chemicals hit the skin and sting, some irritate lungs, and others do much worse if swallowed or spilled. For complex organics like [(2-Methoxyphenyl)Amino]Methanesulphonic Acid, there’s a possibility for irritant effects, maybe even sensitization. Inhalation risks can’t be discounted, particularly in powder or fine droplet forms. It isn’t about paranoia—it’s about knowing before touching.
Proper storage goes a long way. Chemicals like this often do best sealed in cool, dry places, away from sunlight. Keeping incompatible stuff apart gets overlooked more than it should. Simple routines help, like labeling everything clearly. Safety doesn’t require high-tech solutions, just a bit of thoughtful organization and picking up the habit of putting things back where they belong.
Gloves aren’t just for photos in catalogues. Decent nitrile gloves, eye protection, and a lab coat or smock really don’t slow anyone down on the job. I’ve seen the mess created when goggles were left hanging on a hook instead of on someone’s face. Splashes and accidental sprays happen fast; the right gear turns a bad day into a minor annoyance, not a trip to the ER.
Decent ventilation changes the game. Working under a fume hood or with extraction fans running makes dealing with chemicals far less risky. It isn’t enough to have the equipment; using it every single time you open a bottle or weigh out a powder is what matters. Even compounds considered less volatile can give off dust or invisible vapors that linger and build up. Years of experience tell me that habits kept my colleagues and me far safer than rules written on a wall.
It’s not just about rules or warnings. Sharing war stories and lessons learned from close calls cements knowledge better than printed instructions. Running drills on spills or splashes turns panic into action. Everyone, even the seasoned pros, learn new tricks from these run-throughs: from quick neutralization to cleaning and waste disposal. Investing time in real, hands-on training carries weight long after fancy posters peel off the walls.
Disposal often trips up even careful folks. Rinsing chemicals down the drain can cause blowback from regulators and environmental groups. Waste labeling, turning to licensed disposal companies, and keeping waste streams separated goes beyond bureaucracy—it’s how we keep the workspace and environment clean for the next generation.
Trust comes from experience, and experience comes from treating every chemical, no matter how exotic the name, with a bit of humility and a lot of respect. It’s not complicated, but it works: read the data, wear the gear, check the air, train for mistakes, and clean up right. That’s not just compliance. That’s common sense.
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![[(2-Methoxyphenyl)Amino]Methanesulphonic Acid](/static/81c4c90b-3bfe-4770-bbec-fcbf5e0a3809/images/3d/2-methoxyphenyl-amino-methanesulphonic-acid.gif)
| Names | |
| Preferred IUPAC name | N-[(2-methoxyphenyl)amino]methanesulfonic acid |
| Other names |
2-Methoxyaniline methanesulfonic acid o-Anisidine methanesulfonic acid Methanesulfonic acid, [(2-methoxyphenyl)amino]- [(2-Methoxyphenyl)amino]methanesulfonic acid 2-Methoxyphenylaminomethanesulfonic acid |
| Pronunciation | /tuː ˌmɛθ.ɒk.siˈfiː.nɪl əˈmiː.noʊ ˈmɛθ.eɪnˌsʌlˈfɒn.ɪk ˈæs.ɪd/ |
| Identifiers | |
| CAS Number | 18116-80-8 |
| Beilstein Reference | 1608733 |
| ChEBI | CHEBI:132294 |
| ChEMBL | CHEMBL2103837 |
| ChemSpider | 2247116 |
| DrugBank | DB08261 |
| ECHA InfoCard | 100.163.304 |
| Gmelin Reference | 89838 |
| KEGG | C18397 |
| MeSH | D020123 |
| PubChem CID | 21414246 |
| RTECS number | GV3110000 |
| UNII | 6T8ZP7392O |
| UN number | Not regulated |
| Properties | |
| Chemical formula | C8H11NO4S |
| Molar mass | Molar mass: 201.23 g/mol |
| Appearance | White to off-white solid |
| Odor | Odorless |
| Density | 1.34 g/cm3 |
| Solubility in water | soluble |
| log P | -1.1 |
| Acidity (pKa) | 1.03 |
| Basicity (pKb) | 6.38 |
| Refractive index (nD) | 1.594 |
| Dipole moment | 3.0068 Debye |
| Thermochemistry | |
| Std molar entropy (S⦵298) | Std molar entropy (S⦵298) of [(2-Methoxyphenyl)Amino]Methanesulphonic Acid is 330.2 J·mol⁻¹·K⁻¹ |
| Pharmacology | |
| ATC code | N02AC06 |
| Hazards | |
| Main hazards | Causes skin irritation, causes serious eye irritation. |
| GHS labelling | GHS05, GHS07 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P264, P280, P302+P352, P305+P351+P338, P337+P313 |
| NFPA 704 (fire diamond) | 1-1-0 |
| Flash point | > 170.7 °C |
| LD50 (median dose) | LD50 (median dose): 2000 mg/kg (rat, oral) |
| NIOSH | AS8175000 |
| PEL (Permissible) | Not Listed |
| REL (Recommended) | 10 mg/m³ |
| IDLH (Immediate danger) | Not Listed |
| Related compounds | |
| Related compounds |
Methanesulfonic acid Aniline 2-Methoxyaniline p-Anisidine Benzenesulfonic acid |
