Product Name: 2-Hydroxyethanesulphonic Acid
Synonyms: Isethionic Acid, Ethane-2-sulfonic acid, Isethionate
Chemical Formula: C2H6O4S
CAS Number: 107-36-8
EINECS Number: 203-484-3
Recommended Uses: Intermediate in surfactants, pharmaceuticals, and chemical synthesis
Supplier Details: Fill supplier or manufacturer information with address, telephone, emergency phone number for rapid response
Emergency Contact: Refer to supplier emergency number; typically includes poison control or chemical emergency line
GHS Classification: Eye Irritant (Category 2A), Skin Irritant (Category 2), Specific Target Organ Toxicity – Single Exposure (Category 3)
Pictograms: Exclamation mark indicating irritation hazard
Signal Word: Warning
Hazard Statements: Causes skin and serious eye irritation, respiratory tract irritation
Precautionary Statements: Wash hands after handling, wear personal protective equipment, avoid breathing dust, fumes, or mist, use only outdoors or in well-ventilated area
Potential Health Effects: May produce redness, tearing, pain, and conjunctivitis from eye exposure, skin irritation including redness and itchiness, respiratory tract discomfort such as cough or irritation if inhaled, possible stomach upset or nausea if ingested
Chemical Name: 2-Hydroxyethanesulphonic Acid
Concentration: 98–100%
Other Components: Trace impurities typically less than 1% (impurities not considered hazardous based on supplier testing)
Eye Contact: Rinse cautiously with water for 15–20 minutes, remove contact lenses if present and easy to do, seek medical attention immediately
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing, seek medical attention for irritation or burns
Inhalation: Remove person to fresh air, support breathing with oxygen if necessary, seek medical advice if symptoms occur
Ingestion: Rinse mouth thoroughly, never induce vomiting if unconscious, call poison center or physician quickly
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or appropriate foam
Specific Hazards: Non-combustible itself but can emit sulfur oxides when heated or decomposed, which present respiratory dangers
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Procedures: Evacuate area, control runoff to prevent entry into waterways and drains, isolate hazard area
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid dust formation, wear suitable protective equipment
Environmental Precautions: Prevent spillage from reaching drains, surface water, or soil
Cleanup Methods: Sweep or scoop up carefully to avoid dust, place in a closed container for reuse or disposal, wash affected area with water after cleanup
Reporting: Notify local authorities if releases contaminate environment beyond workplace
Handling: Handle with chemical-resistant gloves, avoid contact with eyes, skin, and clothing, use only with adequate ventilation, avoid creating dust and aerosol
Storage Conditions: Keep in tightly closed original container, store in a dry, well-ventilated, cool place away from incompatible materials such as strong bases or oxidizers
Incompatibilities: Reacts with strong bases, strong oxidizing agents, potential for corrosive byproduct formation if stored improperly
Other Precautions: Keep away from food, drink, and animal feed, use spill trays or protection in storage area
Exposure Limits: No occupational exposure limits set by OSHA, NIOSH, or ACGIH for this compound
Engineering Controls: Use local exhaust ventilation to minimize airborne dust, provide eyewash and safety shower within immediate area
Personal Protection: Protective gloves (nitrile or neoprene), chemical splash goggles or full-face shield, lab coat or chemical apron, respiratory protection (dust mask, P2/N95 or higher) if dust or aerosol risk exists
Hygiene Measures: Wash hands after handling, remove contaminated clothing and wash before reuse, regular cleaning of work area
Physical State: White to off-white crystalline solid or powder
Odor: Odorless or slight sulfurous scent
pH (1% solution): Between 1.0 and 2.0, strongly acidic in water
Melting Point: 100–105°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, alcohol, and polar organic solvents
Density: Approximately 1.49 g/cm³
Vapor Pressure: Negligible at room temperature
Flash Point: Not applicable
Auto-ignition Temperature: Not applicable
Partition Coefficient (log Kow): -2.14 (highly water soluble)
Viscosity: Not relevant for solid
Chemical Stability: Stable under recommended conditions of storage and use
Conditions to Avoid: Moisture or water can induce caking, heat, sources of ignition, formation of dust clouds
Incompatible Materials: Strong bases, oxidizers, chlorine compounds
Hazardous Decomposition Products: Sulfur oxides (SOx) may form under high temperature decomposition
Polymerization: Not expected
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg, low acute toxicity in animal studies
Skin Corrosion/Irritation: Causes skin irritation, possible redness and dryness after direct contact
Serious Eye Damage/Irritation: Causes severe eye irritation or damage, may lead to chemical conjunctivitis
Respiratory Sensitization: Dust inhalation can irritate the upper respiratory tract
Chronic Effects: No data showing chronic toxicity or carcinogenicity, not listed by IARC, NTP, or OSHA
Other Information: No expected reproductive or developmental effects at occupational exposures
Ecotoxicity: Not classified as hazardous to aquatic life, no evidence for bioaccumulation, aquatic toxicity expected to be low
Persistence and Degradability: Readily biodegradable through standard environmental processes
Mobility in Soil: Highly mobile in soil and water due to high solubility
Bioaccumulative Potential: Low (log Kow negative, favoring dispersal in water not uptake)
Other Adverse Effects: Acidification of water possible in significant spills, high concentration may damage aquatic organisms by pH effect
Waste Disposal Methods: Dispose of waste product and contaminated packaging through licensed chemical waste contractor or regulated hazardous waste landfill
Precautions: Do not dispose to surface waters, drains, or household garbage
Additional Guidance: Follow local, regional, national, and international regulations for disposal, use dedicated chemical waste containers to prevent cross-contamination
UN Number: UN3265 (if transported as corrosive solid, acidic, organic, n.o.s.)
Proper Shipping Name: Corrosive solid, acidic, organic, n.o.s. (contains 2-Hydroxyethanesulphonic Acid)
Transport Hazard Class: Class 8 (corrosive substances)
Packing Group: III (low hazard)
Environmental Hazards: Not a marine pollutant under IMDG Code
Special Precautions: Keep containers upright, sealed, and away from incompatible goods during transportation
US Regulations: Listed under TSCA Inventory; not regulated as a toxic or hazardous air pollutant; workplace labeling under OSHA required
EU Regulations: Registered under REACH; labeling and safety information per GHS (CLP Regulation 1272/2008/EC)
Canadian Regulations: Listed on DSL/NDSL; WHMIS classification D2B – Skin/Eye Irritant
Asia-Pacific Regulations: Listed in key chemical inventories including China IECSC, Japan ENCS, Korea ECL
Other Labeling Requirements: Container must display hazard, precaution, and supplier contact in accordance with local law
