Product Name: 2-(Cyclohexylamino)Ethanesulphonic Acid
Synonyms: CHES, Cyclohexylaminoethanesulfonic acid
CAS Number: 103-47-9
Manufacturer: Common among laboratory chemical suppliers, including Sigma-Aldrich, TCI, and Alfa Aesar
Recommended Use: Buffering agent in biochemistry, molecular biology, and analytical chemistry
Contact Information: As listed on supplier packaging
GHS Classification: Not classified as hazardous under GHS (Globally Harmonized System of Classification and Labelling of Chemicals) for physical or health hazards
Hazard Statements: Irritation to eyes, skin, and respiratory tract possible following contact, ingestion, or inhalation
Signal Word: Warning
Pictograms: None mandatory, but standard exclamation mark advised for minor irritants
Precautionary Statements: Avoid breathing dust; Use personal protective equipment; Wash hands thoroughly after handling
Potential Health Effects: Short-term exposure may provoke mild irritation of skin, eyes, or respiratory tract; long-term exposure data not well documented; minimal evidence of chronic toxicity in available literature
Chemical Name: 2-(Cyclohexylamino)Ethanesulphonic Acid
Chemical Formula: C8H17NO3S
Molecular Weight: 207.29 g/mol
Purity: Laboratory grade products typically >99% pure
Impurities: Trace moisture possible; sulfate, sodium contamination at minor levels if present
Stabilizers/Additives: None indicated for analytical grade
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; seek medical attention if irritation persists
Skin Contact: Wash with plenty of soap and water for at least 15 minutes; remove contaminated clothing; seek medical advice if symptoms occur
Inhalation: Move person to fresh air; monitor breathing; provide artificial respiration if needed; consult physician if symptoms such as coughing or difficulty breathing develop
Ingestion: Rinse mouth with water; seek medical advice if large quantities ingested or if symptoms (nausea, abdominal pain) appear; never administer anything by mouth to an unconscious person
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide
Unsuitable Media: High volume water jet may spread material
Specific Hazards: May produce toxic gases such as nitrogen oxides, sulfur oxides, carbon monoxide, and carbon dioxide when heated or combusted
Protective Equipment and Precautions for Firefighters: Firefighters require full protective clothing, including self-contained breathing apparatus
Special Procedures: Cool undamaged containers with water spray; evacuate area; avoid inhalation of combustion products
Personal Precautions: Avoid breathing dust; wear suitable protective clothing, gloves, and eye/face protection
Environmental Precautions: Prevent further leakage or spillage; do not allow product to enter drains or waterways
Methods for Clean-Up: Collect spillage using suitable inert absorbent material (sand, diatomite, vermiculite); sweep up and place in suitable closed container for disposal; ventilate area; rinse residue with water if safe to do so
Handling: Minimize dust generation; avoid contact with eyes, skin, and clothing; carry out operations in well-ventilated areas; employ appropriate personal protective equipment
Storage Conditions: Store in tightly closed containers in a cool, dry, and well-ventilated location; keep container upright to prevent spills; segregate from strong oxidizing agents, acids, and bases
Other Precautions: Regularly inspect storage materials for integrity; maintain clear labels on all containers
Exposure Limits: No occupational exposure limits set by OSHA, NIOSH, or ACGIH for this material
Engineering Controls: Use local exhaust ventilation to control airborne dust concentrations
Personal Protection: Wear laboratory coat, chemical-resistant gloves (nitrile or neoprene), and safety goggles; use dust mask or respirator (NIOSH N95 or equivalent) if dust formation occurs
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling; do not eat, drink, or smoke around the material; remove contaminated clothing and wash before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 287 to 289 °C (decomposition)
Boiling Point: Not applicable — decomposes before boiling
pH: 10.0–11.0 (0.1 M in water at 25 °C)
Solubility: Soluble in water; slight solubility in ethanol; insoluble in ether
Density: 1.16 g/cm³ at 20 °C
Vapor Pressure: Negligible at room temperature
Partition Coefficient: log Pow approximately -2.1
Flash Point: Not determined
Evaporation Rate: Not applicable
Chemical Stability: Stable at room temperature and under recommended storage conditions
Reactivity: No hazardous reactions under normal conditions
Conditions to Avoid: Excessive heat, generation of dust, incompatible storage with oxidizers, acids, and bases
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, and carbon monoxide may form during thermal decomposition or combustion
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Low toxicity expected; oral LD50 (rat) >2000 mg/kg
Chronic Toxicity: No evidence of carcinogenicity, mutagenicity, or reproductive effects in available animal studies
Health Effects: Eye and skin irritation possible with contact; inhalation may cause mild respiratory tract irritation; ingestion unlikely to cause harm unless large amounts are consumed
Symptoms of Overexposure: Coughing, sneezing, redness, mild pain or discomfort at site of exposure
Toxicity: No data available for acute aquatic toxicity; not expected to present significant environmental hazard in small laboratory amounts
Persistence and Degradability: Anticipated to be readily biodegradable under environmental conditions
Bioaccumulative Potential: Log Pow value suggests low potential for bioaccumulation
Mobility in Soil: Expected to be mobile in aqueous environments due to high solubility in water
Other Adverse Effects: Large-scale spills may alter water pH; avoid direct release to surface waters, sewers, or soil to prevent unnecessary chemical loading
Waste Disposal Methods: Dispose in accordance with local, regional, and national regulations; collect residue and solutions in labeled, tightly sealed containers
RCRA Status: Not listed as hazardous waste under RCRA regulatory framework
Environmental Precautions: Prevent chemical from entering drains, surface water, or soil in uncontrolled amounts; consult appropriate regulatory agencies regarding disposal of substantial quantities
Contaminated Packaging: Thoroughly rinse empty containers prior to disposal or recycle as appropriate for laboratory chemical containers
UN Number: Not regulated under UN transport system
Transport Hazard Class: Not classified as dangerous goods for transport by air, sea, or road under IATA, IMDG, or ADR standards
Packing Group: Not assigned
Special Precautions: Protect containers from rough handling; minimize movement to prevent breakage and spillage; follow standard carrier protocols for laboratory supplies
US TSCA Inventory: Included
DSL/NDSL (Canada): Listed
REACH (EU): Registration number and status depend on annual tonnage handled; commonly used only in research and development exemptions
SARA Title III: Not subject to reporting
California Prop 65: No listed significant risk as of last update
Other Regulatory References: Not controlled as a specific hazardous substance under OSHA, CERCLA, or CWA; check local codes for any additional requirements due to water solubility and laboratory handling
