Product Name: 2,2'-(Piperazine-1,4-Diyl)Bis(Ethanesulphonic) Acid
Synonyms: PIPES; Piperazine-N,N'-bis(2-ethanesulfonic acid); CAS Number: 5625-37-6
Recommended Use: Buffering agent in biochemistry, life science research
Supplier Details: Typically provided by laboratory or chemical suppliers
Emergency Contact: Call local poison control center or emergency services
GHS Classification: Irritant, Eye Irritation (Category 2A), Skin Irritation (Category 2), Specific target organ toxicity (single exposure, Category 3)
Signal Word: Warning
Hazard Statements: May cause eye irritation, skin irritation, and respiratory irritation
Precautionary Statements: Avoid inhalation of dust, avoid contact with eyes and skin, wash thoroughly after handling
Pictograms: Exclamation mark
Chemical Name: 2,2'-(Piperazine-1,4-Diyl)Bis(Ethanesulphonic) Acid
CAS Number: 5625-37-6
Molecular Formula: C8H18N2O6S2
Molecular Weight: 302.37 g/mol
Concentration: 100% (Standard laboratory grade)
Inhalation: Move individual to fresh air. If breathing difficulty persists, seek medical attention. Remove contaminated clothing and provide oxygen if needed.
Skin Contact: Immediately wash with plenty of water for at least 15 minutes. Remove contaminated clothing. Seek medical attention for anything beyond minor irritation.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical care if irritation continues.
Ingestion: Rinse mouth with water. Do not induce vomiting unless instructed by medical personnel. Seek immediate medical advice.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Specific Hazards: May emit toxic fumes or gases such as sulfur oxides, nitrogen oxides under fire conditions
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Advice: Move containers from area if possible without risk. Keep run-off water from entering drains.
Personal Precautions: Use personal protective equipment including gloves, goggles, and mask. Avoid inhalation of dust and avoid skin contact.
Environmental Precautions: Prevent further leakage or spillage. Avoid discharge into drains, rivers, or soil.
Methods for Cleanup: Carefully sweep or vacuum up spilled material. Place in an appropriate waste container for disposal. Clean spill area with water and detergent. Ventilate area thoroughly.
Handling: Minimize dust generation. Use in well-ventilated environments. Avoid eyes and skin contact. Handle using appropriate safety protocols.
Storage: Store in a tightly closed container. Keep out of direct sunlight. Maintain dry, cool, and well-ventilated conditions. Keep away from incompatible materials such as strong acids and bases.
Exposure Limits: No official occupational exposure limits established.
Engineering Controls: Work in a fume hood or with proper ventilation to prevent dust buildup. Use local exhaust where possible.
Personal Protective Equipment: Wear safety goggles, laboratory gloves, and lab coat. Use a dust mask or respirator when handling large amounts or dusty conditions.
Hygiene: Wash hands thoroughly after handling. Do not eat, drink or smoke near chemical use.
Appearance: White crystalline powder
Odor: Odorless
pH (1% Solution): Approximately 2.5-3.5
Melting Point: Around 280°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in water
Partition Coefficient: Not available
Density: Roughly 1.6 g/cm³
Vapor Pressure: Negligible
Flash Point: Not flammable under standard conditions
Stability in Storage: Stable under normal laboratory storage
Chemical Stability: Stable under recommended conditions
Reactivity: Not considered reactive under normal circumstances
Conditions to Avoid: Excessive heat, moisture, exposure to sunlight
Incompatible Materials: Strong oxidizers, strong acids, strong bases
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, possible carbon oxides on burning or decomposition
Polymerization: Not expected to occur
Acute Toxicity: Low acute oral and inhalation toxicity reported from animal studies
Skin Corrosion/Irritation: Causes temporary skin irritation on contact
Eye Damage/Irritation: May cause redness and irritation with direct eye exposure
Respiratory Sensitization: May cause irritation of upper respiratory tract if dust is inhaled
Carcinogenicity: No data suggesting cancer hazard in humans or animals
Mutagenicity/Teratogenicity: No evidence found in standard testing
Other Effects: Prolonged exposure to large amounts may affect kidney or liver function, though evidence is limited
Ecotoxicity: Not considered particularly hazardous to aquatic life at typical laboratory concentrations
Persistence and Degradability: Expected to degrade slowly in the environment
Bioaccumulation Potential: Low due to water solubility
Mobility in Soil: Highly mobile in aqueous environments
Other Adverse Effects: Avoid uncontrolled release to the environment or large spills
Waste Disposal: Dispose of in accordance with local, regional, and national regulations. Transfer to a licensed chemical disposal company. Incineration or landfill at approved sites.
Contaminated Packaging: Rinse containers with water before disposal, follow all chemical waste guidelines. Do not reuse packaging or pour residues into drains.
Special Precautions: Keep out of surface water and sewer systems unless treated by licensed facility.
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Not regulated—general cargo
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Avoid dust release during loading, unloading, and transport. Double-check container seals.
Labeling: Complies with standard laboratory safety regulations
TSCA Inventory: Listed
REACH Status: Exempt from registration under REACH for research use
OSHA Hazards: Listed as irritant
Other Regulation: Product should be handled in compliance with workplace safety standards and laboratory regulations. Maintain clear documentation and training for personnel.
Right-to-Know Acts: Not specifically listed on SARA, CERCLA, or California Proposition 65. Always confirm with up-to-date state and federal guidance.
