Product Name: 2,2'-(Hydroxyimino)-Bisethanesulfonic Acid Disodium Salt
Synonyms: HOBt-ES, Disodium Salt of 2,2'-(Hydroxyimino)-bis(ethane sulfonic acid)
Manufacturer: Reach out to the supplier or producer directly for exact name and address due to differences in supply chain distribution.
Recommended Use: Analytical reagent, buffer component, coupling agent for peptide synthesis, research and development applications
Emergency Phone Number: Listed on company-specific documentation or made available through poison control centers
Contact Point: Product safety officer’s direct line or chemical safety representative's provided contact
Classification: Skin irritant, Eye irritant, Not classified as a flammable or explosive compound under GHS but prolonged exposure can pose moderate biological risk
Signal Word: Warning
Hazard Statements: Causes mild to moderate skin and eye irritation, harmful in case of ingestion, uncommon inhalation risk at room temperature with proper containment
Pictograms: Exclamation mark (GHS07)
Precautionary Statements: Wear eye protection. Avoid extended skin contact. Do not eat, drink or smoke during use. Seek immediate medical attention if symptoms occur.
Other Hazards: No significant environmental hazard in laboratory-scale quantities with standard disposal; larger spills can affect aquatic organisms because salts increase conductivity in water.
Chemical Name: 2,2'-(Hydroxyimino)-Bisethanesulfonic Acid Disodium Salt
Common Name: HOBt-ES disodium salt
CAS Number: 73463-39-5
EC Number: 277-577-7
Percent Composition: Active ingredient approaches 99% in analytical batches, minor presence of water and trace organic impurities from synthesis
Molecular Formula: C4H6N2O7S2Na2
Impurities and Stabilizing Additives: Essentially negligible in most laboratory settings; check specific certificate for batch-dependent impurities especially for pharmaceutical or food contact work.
Inhalation: Move person to fresh air. If breathing becomes difficult, seek medical help. Persistent irritation or cough should receive clinical attention.
Skin Contact: Remove contaminated clothing immediately. Wash affected area under running water using soap if available, keep watching for redness or rash.
Eye Contact: Flush eyes under water for at least 15 minutes while holding eyelids open, remove contact lenses if present, refer to medical assessment if symptoms persist.
Ingestion: Rinse mouth with water, do not induce vomiting. Drink water if conscious. Promptly seek medical advice if feeling unwell.
Advice for Medical Practitioners: Symptomatic treatment. No reported antidote or targeted therapy.
Delayed Effects: Uncommon unless chronic exposure or underlying conditions; repeated contact may increase risk of dermatitis.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: Avoid using high-pressure water jet as it may disperse material
Special Hazards: Burning produces irritating or toxic fumes, including oxides of nitrogen, sodium, sulfur; may decompose to release SOx and NOx gases
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Firefighting Instructions: Prevent contamination of drains and watercourses, keep chemical drums cooled with water mist
Explosion Data: Product does not present explosion hazard under normal procedure, thermal decomposition in confined space can generate pressure
Personal Precautions: Evacuate unprotected personnel. Use nitrile gloves, chemical splash goggles, face shield, lab coat or coveralls as appropriate for spill size.
Environmental Precautions: Prevent entry into sewers, surface water, or ground water. Notify relevant environmental authorities if large spill reaches watercourse.
Methods for Containment: Stop spill source, dam spill with inert absorbent such as sand or vermiculite.
Cleanup Procedures: Scoop up and transfer to labeled chemical waste container. Wash spill area with water and detergent, avoid respiratory dust generation.
Decontamination: Rinse surface with copious water once solid waste removed. Monitor pH if laboratory drainage is used due to potential effect of sodium salts.
Handling: Always use in well-ventilated area such as a fume hood. Do not handle without personal protective equipment. Avoid creating dust.
Storage: Store tightly sealed in original container, away from incompatible materials (strong acids, oxidizers). Keep away from moisture and direct sunlight. Maintain container at controlled room temperature or as specified by supplier.
Incompatible Materials: Strong mineral acids, reducing agents, strong oxidizers
Special Handling Notes: Keep containers upright and labeled. Avoid contamination of work surfaces—clean up after each use. Do not reuse empty containers for other substances.
Storage Conditions: Temperatures of 2–8°C usually recommended for best shelf-life in research use, make efforts to minimize temperature excursions.
Occupational Exposure Limits: No established ACGIH or OSHA values; adopt control banding for chemical safety.
Engineering Controls: Use of certified chemical fume hood for all open operations involving powder or volatilization, ensure local exhaust available.
Personal Protective Equipment: Nitrile or neoprene gloves, long-sleeved laboratory coat, chemical safety goggles or face shield, dust mask/respirator (NIOSH-approved) where airborne dust is present.
General Hygiene: Avoid eating, drinking, smoking in work area. Wash hands before leaving laboratory, launder contaminated clothing.
Environmental Exposure Controls: Chemical containment practices for bench work, avoid disposal down open drains without dilution and neutralization.
Appearance: White to off-white crystalline powder
Odor: Odorless to faint chemical
Melting Point / Freezing Point: Above 200°C with decomposition
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Highly soluble in water, soluble in methanol, insoluble in nonpolar solvents
pH: Near neutral (pH 6–8 at 1% solution in water)
Relative Density: Approximately 1.6 g/cm3
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient: Not determined (compound is ionic)
Other Properties: No volatile components under normal use, low dusting potential with standard laboratory procedures
Chemical Stability: Stable under recommended storage conditions, deteriorates slowly in presence of moisture or strong acid
Possible Hazardous Reactions: No strong hazardous reactions expected during intended use; reacts with strong acids to release toxic gases
Materials to Avoid: Strong acids, strong bases, oxidizing agents, reduction catalysts
Decomposition Products: Oxides of sulfur, oxides of nitrogen, sodium compounds, water vapor
Conditions to Avoid: Excessive heat, humidity, and contamination with incompatible substances
Polymerization: Product does not undergo hazardous polymerization
Acute Toxicity: Oral LD50 (rat) above 2000 mg/kg; low acute toxicity by inhalation or dermal exposure in animal models
Skin Irritation: Prolonged skin contact causes irritation, possible allergic response with extended or repeated exposure
Eye Irritation: Direct eye contact produces irritation and redness
Sensitization: No sensitization documented in reference literature
Chronic Effects: Repeated overexposure may lead to dermatitis, respiratory irritation if inhaled as dust
Carcinogenicity: Not classified as a carcinogen by NTP, IARC, OSHA
Reproductive Toxicity: Not reported, no indication in published studies
Target Organs: Skin, mucous membranes, and potentially eyes during accidental exposure
Ecotoxicity: No detailed studies available but data for structurally similar compounds suggest moderate toxicity to aquatic invertebrates at high concentrations
Persistence and Degradability: Expected to be persistent due to sulfonic acid group and sodium salt structure
Bioaccumulative Potential: Not expected due to high water solubility and ionic nature
Mobility in Soil: High, likely to disseminate in aqueous environments
Other Adverse Effects: May contribute to increased conductivity in water bodies in case of spill
Waste Treatment Methods: Collect waste in sealed, labeled container. Follow local, regional, and national chemical waste guidelines.
Disposal of Product: Treat as hazardous laboratory waste, send to licensed chemicals disposal facility
Disposal of Packaging: Triple rinse and render packaging unusable if disposing with general laboratory waste, otherwise treat as chemical waste
Special Precautions: Avoid discharge to drains or natural watercourses. Contact environmental protection authorities in case of large quantities.
UN Number: Not regulated as dangerous goods by IATA, IMDG, ADR in typical laboratory quantities
Proper Shipping Name: Chemical, not otherwise specified
Transport Hazard Class: Not classified
Packing Group: Not applicable
Marine Pollutant: None identified
Special Precautions for Transport: Protect from moisture and vibration, maintain secondary packaging for glass containers
TSCA Inventory: Compound included or precursor components registered where required
REACH Registration Number: Required in EU above 1 ton/year, check supplier registration status
SARA Title III: Not listed as reportable quantity substance
California Proposition 65: Not listed
Other Regulatory Info: Subject to workplace control guidelines for chemical safety; not covered by scheduled hazardous substances under OSHA but follow institution-specific risk assessment for laboratory chemicals.
