Product Name: 2,2,2-Trifluoroethyl trifluoromethanesulfonate
Chemical Formula: C3H2F6O3S
Synonyms: Trifluoroethyl triflate, Trifluoromethanesulfonic acid 2,2,2-trifluoroethyl ester
CAS Number: 373-08-4
Recommended Use: Chemical synthesis, pharmaceutical intermediate
Supplier Name: Chemical distributor or laboratory provider
Emergency Contact: National Poison Center, Supplier emergency phone number
Classification: Flammable liquid, Acute toxicity (oral, inhalation), Skin/eye irritant
GHS Label Elements: Flame, Skull and crossbones, Exclamation mark icons
Hazard Statements: Highly flammable liquid and vapor, Harmful if swallowed or inhaled, Causes severe skin burns and eye damage
Precautionary Statements: Avoid all personal contact, use in well-ventilated areas, keep away from ignition sources, wear suitable protective equipment, wash contaminated clothing before reuse
Potential Health Effects: Irritation to skin, eyes, and respiratory system; risk of chemical burns; possible central nervous system depression
Signal Word: Danger
Chemical Name: 2,2,2-Trifluoroethyl trifluoromethanesulfonate
CAS Number: 373-08-4
Concentration: 97-99%
Impurities: Trace amounts of related sulfonates or alcohols (generally below 1%)
Other Ingredients: None
Inhalation: Remove affected person to fresh air, keep comfortable for breathing, administer oxygen if breathing difficulty develops, seek immediate medical attention
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, seek medical attention for persistent irritation or burns
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing and call a physician
Ingestion: Rinse mouth, do not induce vomiting, call poison center or doctor immediately, never give anything by mouth if victim is unconscious
Most Important Symptoms: Burning pain, redness, chemical burns to exposed tissue, respiratory distress, headache, nausea, dizziness
Suitable Extinguishing Media: Carbon dioxide, foam, dry chemical powder, alcohol-resistant foam
Unsuitable Extinguishing Media: Water jets may cause ineffective spreading
Fire Hazards: Vapors may form explosive mixture with air, may emit toxic and corrosive fumes including HF, SOx, and CF3 gases during combustion
Protective Equipment: Self-contained breathing apparatus, full protective clothing
Special Precautions: Fight fire from safe distance, cool fire-exposed containers with water spray, avoid inhalation of combustion products
Personal Precautions: Evacuate area, ventilate, avoid breathing vapors, wear full protective suit including appropriate respirator, chemical-resistant gloves, and safety goggles
Environmental Precautions: Prevent entry into waterways, drains, soil, inform local authorities if product enters environment
Methods for Containment: Contain and collect spillage with non-combustible absorbent material such as vermiculite, sand, or earth, transfer to labeled chemical waste container
Cleanup Procedures: Use spark-proof tools, dispose contaminated material following governmental regulations, decontaminate spill area
Precautions for Safe Handling: Avoid all contact with skin and eyes, prevent vapor or aerosol formation, ground/bond container and receiving equipment, use explosion-proof electrical and ventilation systems, never handle near open flames or hot surfaces
Safe Storage Requirements: Store in tightly closed containers in a cool, dry, well-ventilated place away from incompatible substances (such as water, oxidizers, and bases), keep away from direct sunlight and heat sources, segregate from chemicals with which it reacts violently
Specific Use Considerations: Only trained personnel should manage or dispense, limit quantities stored, maintain chemical inventory and inspection protocols
Engineering Controls: Use chemical fume hood, local exhaust ventilation, explosion-proof equipment
Occupational Exposure Limits: No specific limits set, minimize exposure as much as possible
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), lab coat, safety goggles or full face shield, suitable respiratory protection like NIOSH-approved organic vapor respirator if exposure risk
Hygiene Measures: Wash hands and face before breaks and immediately after handling, no eating, drinking, or smoking while working with the substance
Monitoring: Regular air monitoring for volatile organics in work area
Appearance: Clear, colorless to slightly pale liquid
Odor: Slightly pungent, characteristic
pH: Not applicable
Melting Point/Freezing Point: Below -30°C
Boiling Point / Range: 77-80°C (at 760 mmHg)
Flash Point: Below 23°C (closed cup)
Evaporation Rate: Rapid under ambient conditions
Flammability: Highly flammable liquid
Explosive Limits: Data not available, vapor forms explosive mixture with air
Vapor Pressure: ~30 mmHg at 20°C
Vapor Density: Heavier than air
Relative Density: 1.54 at 20°C
Solubility: Hydrolyzes in water, miscible with most organic solvents
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: 210°C
Decomposition Temperature: Above 120°C
Viscosity: Low (mobile liquid)
Chemical Stability: Stable in tightly closed container under recommended storage conditions, sensitive to moisture
Reactivity: Rapid hydrolysis in water, reacts violently with strong bases, strong acids, and oxidizers, generates hazardous gases on decomposition
Hazardous Decomposition Products: Hydrogen fluoride, sulfur oxides, perfluorinated organics, toxic fumes
Conditions to Avoid: Heat, flame, sparks, moisture, incompatibles
Incompatible Materials: Water, strong bases, oxidizing agents, reducing agents, amines
Acute Toxicity (Estimated): Harmful by inhalation, ingestion, and skin absorption, oral LD50 (rat) estimated 200-500 mg/kg
Skin Corrosion/Irritation: Causes burns, potential for delayed symptoms
Serious Eye Damage/Irritation: Burns to eyes, possible irreversible damage
Respiratory or Skin Sensitization: Not classified as sensitizer, vapors may cause respiratory tract irritation
Germ Cell Mutagenicity: No available data
Carcinogenicity: Not classified by IARC, NTP, or OSHA
Reproductive Toxicity: No data available, avoid exposure
STOT-Single Exposure: Possible central nervous system effects
STOT-Repeated Exposure: Prolonged exposure may cause organ damage
Aspiration Hazard: Risk if aspirated into the lungs
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Expected to be persistent, slow degradation and high stability in environment due to fluoroalkyl structure
Bioaccumulative Potential: May bioaccumulate, data is limited but persistence suggests risk
Mobility in Soil: Likely moderate mobility, may leach to groundwater, volatility may cause air dispersion
Other Adverse Effects: No data on ozone depletion or global warming potential, caution required due to unknowns in environmental impact
Waste Disposal: Consult with licensed waste disposal contractor, destroy product by incineration in approved facility with scrubber for acidic and fluorinated gases
Contaminated Packaging: Rinse with suitable solvent, dispose as hazardous waste, do not reuse containers
Special Precautions: Avoid release to the environment, handle residues and washes as hazardous wastes, follow all federal, state, and local regulations on chemical disposal
UN Number: 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (2,2,2-Trifluoroethyl trifluoromethanesulfonate)
Transport Hazard Class(es): 3 (Flammable liquid)
Packing Group: II
Marine Pollutant: Yes, dangerous to aquatic life
Special Transport Precautions: Use explosion-proof vehicles, secure containers upright, keep away from sources of ignition and moisture during transport, ensure trained personnel handle
OSHA: Listed as hazardous chemical
TSCA: Listed
SARA 313: Not subject to reporting
REACH: Substance subject to restrictions and registration in Europe
California Proposition 65: Not listed
Other Chemical Inventories: Check compliance with country-specific directives, restrictions may apply for production, distribution, and use
Workplace Labelling: Ensure containers are labelled with GHS symbols, signal words, and hazard statements according to local and international regulations
