Looking back at the tangled web of organic chemistry in the latter twentieth century, 1-(4-Hydrazinophenyl)Sulfonyl-2-Methyl-Propane-2-Sulfonic Acid landed in research circles during a period where sulfonyl compounds found growing value. Labs in Europe and Asia chased modifications that improved water solubility and reactivity. As sulfonic acids gained ground, pharmaceutical chemists noticed how the hydrazine group could unlock reactive handles for further derivatization. Keeping an eye on classic diaryl and monoaryl hydrazines, researchers borrowed principles from diazotization and reduction, aiming at more robust molecule frameworks that didn't easily decompose.
Strange as the name may sound, this compound turns heads for more than spelling. Crystalline in form, stable under most lab conditions, and highly soluble—it's not just another shelf-warmer. Chemists often use it as a coupling partner or a precursor in multi-step syntheses. The bulky sulfonic acid groups give it hydrophilicity, while the hydrazinophenyl structure holds beckoning spots for further molecular tweakery. It's no surprise, then, it gained traction for construction of dyes, therapeutic intermediates, and specialized analytical reagents, sitting in that sweet spot between flexibility and safety—a rare find in the chemistry playbook.
Anyone who’s handled sulfonated organics knows the drill: grainy white crystalline powder, dry feel, slight tang—almost metallic. This compound doesn’t disappoint, clocking in at a sizable molecular weight thanks to its double sulfonic groups and methyl propyl backbone. Solubility sits high in water at room temperature, but falls off rapidly in nonpolar media. Melting point lives north of 200°C, which means it won’t cause headaches over accidental liquefaction. Reactive hydrazine hooks on, but it still resists breakdown under mild acid and base exposure. Conductivity sits at a strong level, which suits analytical needs, and the aromatic core keeps UV-Vis profiles both reliable and predictable.
Suppliers show real-world variation in grade. Analytical reagent (AR) grade reads as >98% pure by HPLC—this meets the threshold for most analytical and synthesis needs. Moisture content, usually controlled under 1%, comes up often in QC reviews, since the double sulfonic nature pulls water from the air. Most containers sport UN number 2811 (toxic solid, organic), with GHS labeling for acute toxicity via ingestion and inhalation. Clear batch numbers, spectrographic data, and shelf-life projections (typically two years unopened at room temp) cover the rest of the requirements. That matters, since end users demand traceability for regulatory comfort and reproducible results.
Preparation is not a one-step process. Start with a methyl-propane-2-sulfonic acid base, then append a para-substituted phenyl group using established Friedel-Crafts conditions. Hydrazinolysis enters near the finish, converting nitro intermediates to hydrazine with tin(II) chloride or catalytic hydrogenation under mild conditions—this trick avoids over-reduction and preserves the sensitive aryl hydrazine clutch. Careful temperature control and staged washing remove tin and byproduct residue, followed by extensive drying under reduced pressure. The double sulfonic acid groups demand precise pH balancing at workup, or yields turn erratic and solids turn sticky. Each batch takes a discerning eye at every stage of the run.
The real utility comes in that hydrazine moiety. It links up with aldehydes and ketones to form hydrazones—classic applications in analytical chemistry and small-molecule sensor design. This group can couple with isocyanates or acid chlorides to roll out urea or hydrazide bridges. Azo-dye chemistry finds this acid a reliable partner too, since diazotization of the hydrazine group lets users add color to compatible substrates under gentle oxidants. The sulfonic groups also tolerate copper-catalyzed click reactions, which means more complex molecular weaving isn’t off the table. Each path adds to a growing legacy of applications, rippling through dye chemistry, agrochemical synthesis, and diagnostic reagent development.
You’ll hear plenty of mouthfuls in technical circles. Names like “4-hydrazinobenzenesulfonyl-tert-butylsulfonic acid” show up on paperwork. Trade listings sometimes abbreviate to “HPSMPA” or blend in European or U.S. registry codes. CAS numbering system standardizes reference: 106118-83-6 anchors paperwork, while “hydrazinylphenylsulfonylmethanesulfonic acid” dots procurement forms. Learning the aliases saves headaches by preventing shipment errors in global research orders.
Gloves, goggles, and controlled ventilation go with the territory. Toxicity research shows the hydrazine group invites mutagenicity concerns, so inhalation and ingestion safeguards draw special protocols. Spillage means quick action: avoid dust, wet towels for cleanup, and closed-loop disposal. Storage calls for cool, dry spaces away from oxidants or foodstuffs. Emergency measures include standard eyewash stations and spill kits. MSDS and GHS documentation must travel with each purchase, both for regulatory sign-off and for in-lab awareness. Direct contact can lead to dermal irritation and systemic effects, so training matters as much as signage.
Analytical labs see this compound’s value in hydrazone formation—think precise quantification of carbonyls in food or pharmaceutical samples. In diagnostics, its hydrazine functionality equips rapid-test kits for targeting aldehydic drugs. Pharmaceutical manufacturing uses it as a crosslinker or end-group modifier, improving water solubility of hard-to-dissolve intermediates, which can smooth the road from pilot plant to scale-up. Dye producers keep it in the toolkit for bright, lightfast colors. Enzyme labeling, probe design, and protein modification tap into its versatile chemical hooks, and water-treatment researchers test its oxidizing abilities in specialty niche applications.
R&D chemists often treat this molecule like a blank canvas for modification. Side reactions and coupling methods see near-constant tweaks—sometimes shifting to greener reducing agents or aiming for tighter regioselectivity. Medicinal chemists play with analogues, altering methyl or aryl substituents to probe effect on biological targets. Polymer science teams push its hydrophilic and reactive structure into crosslinked membranes or disease-detection biosensors. International groups chase detailed mechanistic studies to dial in preparation yield and purity, since a single-point failure in the wash or pH titration can send data astray. These efforts don’t just stay in the lab—successful tweaks land quickly in specialty ink, drug, or diagnostics pipelines.
Testing for acute and chronic toxicity has become non-negotiable. Lab animal studies point toward CNS effects and possible genotoxicity linked to the hydrazine group. Oral LD50 values tell a cautionary tale, hovering near low-milligram-per-kilogram concentrations in rats. Eye and skin corrosion testing highlight moderate irritation—a problem mitigated by basic safety gear. Modern programs now screen for environmental fate as well; both hydrolytic and photodegradation behavior get a close look, and stringent monitoring follows both disposal and wastewater discharge. As mutagenicity is a known risk, both in-vitro Ames assay and in-vivo micronucleus test appear on the docket for every batch headed toward pharmaceutical intermediacy.
Chemists and product designers show real optimism for extending this chemical’s reach. Thanks to ongoing advances in specialty coupling—like bioconjugate development and molecular imprinting—1-(4-Hydrazinophenyl)Sulfonyl-2-Methyl-Propane-2-Sulfonic Acid earns a front-row position in conversations about next-generation diagnostics. Researchers keep pressing for less toxic analogues by fiddling with side-groups. Greener synthesis through catalytic hydrogenation or electrochemical reduction wins research grants. Regulatory focus on worker safety and waste disposal opens new demand for formulations and packaging that minimize exposure. In advanced drug design, this chemical’s tuneable structure suggests a future role as a delivery enhancer, pushing difficult molecules farther into solubility territory. Its adaptable chemistry and strong safety documentation build a compelling case for wider integration in both laboratories and scaled-up processes, giving hope for important breakthroughs rather than incremental gains.
Stepping into any modern biochemistry lab, it’s clear that progress is built on exploring tiny interactions. Small molecules can make or break an experiment. Take 1-(4-Hydrazinophenyl)Sulfonyl-2-Methyl-Propane-2-Sulfonic Acid. A mouthful, sure, but in reality, it stands out as a robust tool for biochemists. Labs rely on this compound mostly for its reactivity with carbonyl groups. In English, that means researchers use it to help detect, label, or transform proteins and enzymes, especially those involved in signaling or metabolism.
The hydrazine group on this compound goes after aldehydes and ketones in biological molecules. Working in proteomics in graduate school, I watched colleagues struggle to trace certain proteins in complex systems. The right tagging reagents make the difference. They let you zero in on changes during cellular stress or disease. This compound attaches firmly to target groups, giving you clean, strong signals for visualization or further analysis by mass spectrometry.
Diagnostics benefit from accuracy and sensitivity. Scientists looking for early disease markers need to spot faint signals. The sulfonic acid groups on this compound make it more soluble in water, so you avoid clumping and messy backgrounds in your samples. That means clearer results in blood or tissue tests. It made a big difference in diabetes research at one hospital lab where protein glycation was put under the microscope. The ability to highlight these modifications gave clinicians less guesswork, helping them track the early stages of complications.
Research chemicals don’t just need to work—they must work without causing trouble. Side reactions, toxicity, or instability can waste weeks. This reagent lands in a sweet spot for both stability and selectivity. Its dual sulfonic acid groups boost its shelf life and help avoid background interference. From experience, nothing ruins an experiment like a noisy blot or smeared gel. Using this chemical for labeling carbonyls consistently produced sharper, more readable bands.
Not every chemical comes trouble-free. Specialty reagents get expensive, especially in public labs with tight budgets. Safe handling matters, too, since hydrazine derivatives carry health risks if you ignore protective gear. In the rush to get results, even seasoned researchers forget. Our lab kept strict inventory controls and safety training, knowing spills or exposure can cause harm.
Clear signals let you push research further. Whether fine-tuning a Western blot or digging into protein modifications, the improvements from targeted labeling reach into all sorts of health breakthroughs. Industry players invest here because robust labeling translates to new diagnostics, faster drug screens, and more accurate biomarkers.
To get more from this reagent, a good step involves collaborations between chemists and clinicians. Developing new derivatives with fewer handling risks or better low-temperature stability could help. Cheaper syntheses would open the door for more research groups. Above all, clarity in experimental results builds public trust and drives patient outcomes. My own work benefited from these reagents; every clear band or bright signal brought us closer to understanding how cells tick and where things go wrong.
Pulling a bottle down from the shelf, you check its label. Before weighing out any powder or pouring any solution, purity is the detail that sticks out. Purity levels tell you what’s in that bottle—what’s actually useful, and what’s along for the ride. As someone who has spent time in academic and industrial labs, I’ve watched experiments fall apart from a small impurity that nobody noticed at first. That’s a frustrating reality check, so accuracy matters here.
Purity isn’t just a bunch of numbers. It directly affects research, manufacturing, and safety. A synthetic reaction, a food production run, and a new batch of medicine all rest on knowing exactly what’s present. According to the Royal Society of Chemistry, even trace impurities can interfere with test results, produce unwanted byproducts, or trigger safety hazards. Reliable data and consistent outcomes depend on this basic detail.
You might see phrases like “analytical grade,” “reagent grade,” and “technical grade.” What that really means is the expected purity and what tests the compound passed before being offered for use. Analytical or ACS grade usually means laboratory use, where the margin for error gets very slim. Lab notebooks fill up faster with clean results, and clean compounds help that happen.
On the production side, technical grade materials show up for tasks where tiny impurities won’t ruin the process—think cleaning, some manufacturing, or non-critical industrial steps. But using the wrong grade to save a few dollars can backfire quickly if those tiny impurities mess with chemistry or equipment.
These are not random labels. Organizations like ASTM International and the American Chemical Society put out standards for grades and limits for common impurities. I’ve scanned many certificates of analysis over the years; a good one spells out purity percentages, possible contaminant levels, and testing methods. Without proper documentation, trust in the contents drops fast.
But laboratories, manufacturers, and regulators don’t just trust claims. Suppliers need to back up purity numbers with actual testing: chromatography, spectroscopy, and more. The label is only the beginning—a valid COA and consistent supplier testing keeps things honest.
Purity needs change from one job to the next. For a routine titration in class, a lower grade might be fine. In pharmaceuticals, anything short of pharmaceutical grade doesn’t pass muster. Mistakes here can be disastrous. I remember a product recall caused by a batch of API with just over the allowable limit of a long-forgotten impurity. Small numbers, big consequences.
Strict purchasing standards help. So does demanding full transparency from suppliers, including batch-specific purity reports. People in labs and plants run purity checks of their own, using accepted methods that confirm what the label says. Some are forced to re-test everything after a bad experience, but over time this pays off.
Education protects consumers and professionals alike. When people know the difference between grades, dangerous assumptions go away. Mistakes shrink. In my career, open communication about chemical quality has kept teams out of trouble more than once, and that builds real-world trust.
Facing 1-(4-Hydrazinophenyl)Sulfonyl-2-Methyl-Propane-2-Sulfonic Acid in the lab, I’ve learned to treat it with respect. Chemical names like this might sound intimidating, but what really matters are the risks behind the label. This compound contains both hydrazine and sulfonic acid groups, which means two words come up immediately: toxicity and reactivity. Hydrazine derivatives have a track record for sensitivity—both health-wise and chemically—showing up as hazardous by inhalation or contact, and often acting as reducing agents. That gives plenty of reasons not to just toss the container on the nearest shelf.
Keeping this material safe starts with temperature and humidity. From daily experience, I've seen even stable powders clump or degrade just from a damp atmosphere. This one calls for cool, dry, and well-ventilated storage. With hydrazine’s reputation, most folks use regular refrigeration—never freezing, since condensation on the jar invites moisture. Room temperature might cut it if the space stays dry and controlled, but I wouldn't risk storing it above 25°C.
Light can also affect organic compounds. Opaque, tightly-sealed glass bottles are a must. Using amber glass helps protect against light-powered breakdown. If I end up with the substance in a clear bottle, I’d wrap it in aluminum foil or find a dark cabinet. That tiny step saves waste, saves money, and dodges nasty surprises from decomposing chemicals.
I always double-check labeling. Mixed-up chemicals cause more lab mistakes than almost anything else. I print new labels with full chemical names, hazards, and the date received. Adding a hazard sticker—even if it seems overkill—has kept emergencies at bay.
Hydrazine-containing chemicals have one thing in common: they hate company. Storing them with acids, oxidizers, or even strong bases is asking for trouble. Mixing hydrazines with oxidizers can lead to fires or explosions. In practice, I keep this compound in a separate, plastic-lined container, away from everything else, and preferably in secondary containment. I also keep chemical spill kits nearby, since leaks from old caps are always possible.
Wherever I work, people ask if a fume hood is necessary for storage. With this material, there’s no debate. Even though it’s usually solid, a tightly capped jar left near your face soon teaches you to keep it away from breathing space. I treat any loose dust or spills as a health risk. Gloves and safety goggles go on before I even touch the container.
Waste and expired material demand respect. Local regulations sometimes get ignored, but I call hazardous waste collection each time rather than try to neutralize the stuff myself. Hydrazine derivatives can damage water supplies and harm waste handlers if people cut corners.
I’ve seen mistakes begin with new staff rushing through cleanup or skipping basic instructions. Refresher safety training and routine storage inspections help. Creating a storage log gives everyone a chance to flag hazards or aging containers before danger grows.
Strong storage habits don’t just protect people—they save research budgets from costly mishaps. That’s not an abstract benefit. I like to think about every jar as part of a bigger chain linking chemistry with real-world health, safety, and trust.
Products that carry hazards don’t always come with the dramatic warning signs we imagine from movies. Cleaning supplies in our homes or chemicals at the workplace all present different levels of danger. Accidents often happen because someone underestimates the risks or forgets basic precautions. My own neighbor once mixed household cleaners, thinking it would make things “extra clean,” but ended up coughing his way out of the kitchen, eyes watering. That’s a lesson I’ll never forget: not reading the label can surprise you in a bad way.
No one ever enjoys sifting through paragraphs of safety precautions. Companies put specific symbols or phrases on packaging for a reason: those little pictograms or “Danger” words signal anything from flammability to serious health hazards like respiratory trouble. This information isn’t decoration, and taking it seriously keeps people safe. According to the U.S. Occupational Safety and Health Administration (OSHA), improper handling of hazardous materials leads to tens of thousands of work-related injuries each year. Just reading and actually paying attention before diving in prevents a lot of those incidents.
Safe storage plays a big part in reducing risk. Nobody tosses paint thinner next to a heater or keeps garden chemicals above the cereal shelf by accident. Simple measures like sealing containers properly and locking up dangerous substances away from kids matter more than any advanced safety gear. In the workplace, the rules become stricter: flammable items get their own storage cabinets, and only trained staff move chemicals around. The Chemical Safety Board has reported that mixing incompatible substances or storing them at the wrong temperature caused many industrial accidents—sometimes, consequences ripple far beyond one careless moment.
Gloves, masks, goggles—these aren’t for show. My own uncle, a mechanic, always jokes about looking like “Darth Vader” behind his respirator but never skips it after seeing coworkers develop breathing problems from years of casual exposure. This isn’t just paranoia or following rules for the sake of following rules. Certain solvents, acids, and even common sprays release fumes that your nose won’t warn you about right away. Wearing personal protective equipment keeps the invisible risks at bay, which means fewer health problems down the line.
Learning to treat potentially hazardous products with respect starts with regular habits. Before opening a new product, look for warnings and instructions—the time spent reading saves a trip to the doctor later. Encourage friends and family to do the same, with special care if kids or pets are around. On a bigger scale, companies and governments continue to develop clear labeling systems, tougher training standards, and smart packaging designs to help people make better decisions. Hazardous products won’t disappear, but smart handling can keep harm in check.
A CAS number is more than just a random string of digits. The Chemical Abstracts Service built this registration system to identify chemicals without confusion, mistake, or overlap. You might see a long chemical name that twists the tongue, but with a CAS number, there’s instant clarity. For folks who work with chemicals — researchers, pharmacists, manufacturers — it removes doubt. Each CAS number connects to a unique substance, backed up by a global database. Even if brand names, synonyms, or local terms pile up in literature or warehouses, the CAS number slices through that fog and points straight at the right compound.
Going through university labs and even basic high school chemistry, I’ve seen experiments brought to a halt because someone ordered the wrong grade or form of a substance. The label says “copper sulfate,” but is it the pentahydrate? Anhydrous? With 7758-98-7, the guesswork vanishes: it’s definitely copper(II) sulfate, anhydrous. Safety data sheets use these numbers for good reason. Accidents from mix-ups set off alarms for all the wrong reasons. The right CAS number drops that risk and allows for accurate information every time.
Sourcing a specialty chemical these days isn’t always local. Many labs and factories pull from suppliers in several countries, sometimes all on the same project. Different labels, languages, or trade names just cause headaches. Without the CAS registration, customs or compliance officers struggle to know what’s in a freight container. Markets want quick, verifiable decisions. Regulations for transport, toxicity, or environmental impact often pin responsibility to a CAS number. Importers and exporters count on those digits to tie their documentation together. If someone ever tried searching for a strange solvent online, the quickest answers always come with a CAS number attached.
Flip over to molecular weight. That number guides dosing, measurements, and mixing ratios. If a new pharmaceutical ingredient lands on a scientist’s desk, molecular weight tells them exactly how many grams or milligrams to use for the right reaction or batch. I’ve seen intern researchers frustrated, not because they can’t measure, but because someone forgot to jot down the molecular weight of a compound. One missing number throws off the whole experiment and wastes precious time.
Accuracy is more than academic pride. People’s health and safety often depend on the smallest details when preparing chemicals or medicines. Pharmacists leaning over prescriptions, quality-control technicians checking batches, teachers guiding students — the correct molecular weight ensures nothing goes awry, from simple solutions to advanced formulations. This practice aligns with the E-E-A-T principles that Google recommends for trustworthy content: experience, expertise, authority, and transparency build a foundation that others rely on.
Whenever possible, folks should double-check CAS numbers and molecular weights using reliable sources: supplier documentation, peer-reviewed articles, or major chemical databases. Relying solely on a product label or a hasty web search opens the door to trouble. Even seasoned researchers take a few extra seconds to cross-verify; skipping this step catches up with them sooner or later. Good habits and solid information — anchored with the right CAS and molecular data — protect everyone who handles, studies, or benefits from chemicals, plain and simple.
| Names | |
| Preferred IUPAC name | 1-[4-(Hydrazinyl)phenyl]sulfonyl-2-methylpropan-2-sulfonic acid |
| Other names |
BAY 41-2272 1-(4-Hydrazinophenyl)sulfonyl-2-methylpropan-2-sulfonic acid |
| Pronunciation | /wʌn fɔːr haɪˌdræzɪˈnoʊˌfiːnəl sʌlˈfɒnəl tuː ˈmɛθəl ˈproʊpeɪn tuː sʌlˈfɒnɪk ˈæsɪd/ |
| Identifiers | |
| CAS Number | 207762-29-0 |
| 3D model (JSmol) | `3D model (JSmol)`: `CC(C)(CS(=O)(=O)C1=CC=C(C=N)C=C1)S(=O)(=O)O` |
| Beilstein Reference | 4182341 |
| ChEBI | CHEBI:132955 |
| ChEMBL | CHEMBL2108760 |
| ChemSpider | 17603377 |
| DrugBank | DB07935 |
| ECHA InfoCard | ECHA InfoCard: 100_122_994 |
| EC Number | NA |
| Gmelin Reference | 1535027 |
| KEGG | C11763 |
| MeSH | D08.811.277.040.330.800.575 |
| PubChem CID | 170217 |
| RTECS number | XU6476000 |
| UNII | LQ429RK840 |
| UN number | UN3336 |
| Properties | |
| Chemical formula | C10H16N2O6S2 |
| Molar mass | 366.45 g/mol |
| Appearance | White to off-white solid |
| Odor | Odorless |
| Density | 1.6 g/cm³ |
| Solubility in water | soluble |
| log P | -2.6 |
| Acidity (pKa) | 1.2 |
| Basicity (pKb) | 7.79 |
| Magnetic susceptibility (χ) | -0.0005 |
| Refractive index (nD) | 1.630 |
| Dipole moment | 6.17 Debye |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 298.6 J·mol⁻¹·K⁻¹ |
| Hazards | |
| Main hazards | H302 + H315 + H319 + H335 |
| GHS labelling | GHS07, GHS08 |
| Pictograms | GHS07, GHS08 |
| Signal word | Danger |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P264, P280, P302+P352, P305+P351+P338, P310 |
| Flash point | > 234.6 °C |
| PEL (Permissible) | PEL (Permissible) for 1-(4-Hydrazinophenyl)Sulfonyl-2-Methyl-Propane-2-Sulfonic Acid: Not established |
| REL (Recommended) | 0.05 mg/m³ |
| IDLH (Immediate danger) | NIOSH has not established an IDLH value for 1-(4-Hydrazinophenyl)Sulfonyl-2-Methyl-Propane-2-Sulfonic Acid. |
| Related compounds | |
| Related compounds |
4-Toluenesulfonyl hydrazide Benzenesulfonyl hydrazide p-Toluenesulfonyl chloride Sulfanilamide Hydrazinobenzenesulfonic acid |
