Product Name: 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-Sulphonyl Fluoride
Synonyms: Nonafluorobutanesulfonyl fluoride, NfBSF
Chemical Formula: C4F9SO2F
Molecular Weight: 302.09 g/mol
Recommended Use: Research and industrial chemical syntheses
Supplier: Chemical distribution company or laboratory supplier (contact information as per purchase)
Emergency Phone Number: Refer to local/national poison center or supplier emergency line.
Product Code: Supplied by manufacturer
CAS Registry Number: 375-72-4
Classification (GHS): Acute toxicity (oral, dermal, inhalation), Skin corrosion/irritation, Eye damage/irritation, Specific target organ toxicity
Label Elements: Danger pictogram, Signal word: Danger
Hazard Statements: Harmful if swallowed, causes severe skin burns and eye damage, may cause respiratory irritation
Precautionary Statements: Avoid inhalation/skin contact/eye contact, wear appropriate personal protective equipment, wash thoroughly after handling
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Emergency Overview: Clear, colorless liquid, strong sulfurous odor, reacts rapidly with water, causes burns
Potential Health Effects: Burns to mucous membranes, eyes, skin; systemic toxicity possible on significant exposure; not classified as carcinogen but long-term data lacking
Chemical Name: 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-Sulphonyl Fluoride
CAS Number: 375-72-4
Concentration: ≥95%
Impurities: Perfluoroalkanesulfonyl fluorides as minor byproducts, trace organic solvents depending on supplier
Stabilizing Agents: None required; use as supplied
Inhalation: Remove person to fresh air, ensure airway is open, get medical help if symptoms persist such as coughing, irritation, or shortness of breath
Skin Contact: Remove contaminated clothing, wash skin immediately with large volumes of water, seek urgent medical attention for burns or blistering
Eye Contact: Rinse cautiously with water for at least 15 minutes, keep eyelids open, remove contact lenses if present, continue rinsing, call poison center or doctor immediately
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical attention without delay
Symptoms: Burning sensation, redness, pain, possible delayed pulmonary symptoms
Note to Physician: Treat symptomatically, monitor for chemical pneumonitis and systemic effects including electrolyte disturbances
Extinguishing Media: Carbon dioxide, dry chemical, foam; do not use water directly on spill but use water spray for cooling containers
Specific Hazards: Decomposes upon heating, emits toxic fumes including hydrogen fluoride, sulfur oxides, perfluorinated compounds
Protection for Firefighters: Wear full-body turnout gear and positive-pressure self-contained breathing apparatus
Firefighting Procedures: Move containers away from fire if safe, keep cool with water spray, avoid inhalation of smoke and fumes
Explosion Risk: Not considered explosive, though containers may rupture under intense heat
Hazardous Combustion Products: Hydrogen fluoride, sulfur dioxide, perfluorinated carbon fragments
Personal Precautions: Evacuate unnecessary personnel, ventilate area, use protective clothing and respiratory protection
Environmental Precautions: Prevent from entering drains or watercourses, alert local environmental authorities if significant release occurs
Methods for Clean-Up: Absorb with inert material like vermiculite or sand, place in clearly labeled chemical waste containers, wash area thoroughly after material collection
Decontamination: Wash spill site with large amounts of water after cleaning up residue. Avoid skin and eye exposure throughout process
Special Consideration: Risk of delayed effects from inhaling vapor; monitor for symptoms up to 24 hours post-exposure
Disposal of Clean-Up Materials: Treat absorbent and materials as hazardous waste
Handling Guidelines: Work in fume hood or well-ventilated area, avoid breathing vapors, prevent skin and eye contact, use only with compatible equipment, wash hands after use
Storage Conditions: Store in original container tightly closed, cool, dry, and well-ventilated area, away from sources of moisture and incompatible substances
Incompatibilities: Strong bases, acids, aqueous solutions, reactive metals
Storage Class: Corrosive substances, segregate from foodstuffs and incompatible chemicals
Specific Practices: Clearly label containers; lock hazardous chemical cupboards; check regularly for leaks
Control Parameters: No established occupational exposure limits for this compound, control exposure to lowest feasible concentration
Engineering Controls: Fume hood, local exhaust ventilation, eye wash station nearby, safety shower available
Respiratory Protection: Suitable full-face respirator (minimum NIOSH-approved for acid gases and particulates) for high vapor concentrations or accident clean-up
Skin Protection: Chemical-resistant gloves (fluoroelastomer or butyl rubber), long-sleeved protective clothing, chemical apron
Eye/Face Protection: Full face shield over safety goggles
General Hygiene: Wash hands and face thoroughly after handling, remove contaminated clothing promptly
Specific PPE Considerations: Ensure gloves and clothing are not compromised by repeated exposure; replace if damaged
Appearance: Clear, colorless to faintly yellow liquid
Odor: Sharp, sulfur-like
Odor Threshold: Not established
pH: Not applicable/does not apply to neat compound
Melting Point: -30°C to -25°C (estimate)
Boiling Point: 76–80°C at atmospheric pressure
Flash Point: Not flammable under standard conditions
Evaporation Rate: No data, likely moderate due to volatility
Flammability: Not classified as flammable; vapors may be denser than air
Vapor Pressure: 40–50 mmHg at 20°C (approximate)
Vapor Density: >1 (air=1)
Relative Density: 1.6–1.8 g/cm³ (at 25°C)
Solubility: Poor in water, hydrolyzes; soluble in organic solvents such as acetone, dichloromethane
Partition Coefficient (n-octanol/water): Data not available
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Can decompose above 120°C
Viscosity: No reliable data
Molecular Structure: Perfluorinated butyl backbone with sulfonyl fluoride moiety
Chemical Stability: Stable under recommended storage conditions, reacts with water and bases
Reactivity: Hydrolyzes to form strong acids, violent reaction possible with incompatible substances
Conditions to Avoid: Humidity, direct sunlight, high temperatures
Incompatible Materials: Water, strong bases, amines, alcohols, strong reducing agents
Hazardous Decomposition Products: Hydrogen fluoride gas, sulfur dioxide, perfluorinated fragments
Polymerization: Hazardous polymerization does not occur
Corrosivity: Corrosive to tissue, metals in the presence of moisture
Special Reactivity: Contact with moist air leads to slow decomposition and release of hazardous vapors
Acute Toxicity: Harmful by ingestion, inhalation, or skin contact; LD50 data in animals limited, use precautions as with corrosive, toxic chemicals
Skin Corrosion/Irritation: Severely corrosive, causes burns and possible ulceration
Eye Damage/Irritation: Direct contact causes burns, permanent eye injury or blindness possible
Respiratory Sensitization: Not known to be a respiratory sensitizer
Skin Sensitization: Not well studied, but risk of allergic reactions exists
Mutagenicity/Carcinogenicity: No data, perfluorinated compounds may accumulate in the body over time
Reproductive Toxicity: Not established for this specific compound, avoid exposure especially during pregnancy
Chronic Exposure: Inhalation of vapors or hydrocarbons over extended period could cause systemic symptoms, flu-like syndrome (“polymer fume fever”), risk of liver or kidney damage in extreme cases
Medical Surveillance: Regular health checks recommended for those regularly handling large quantities
Notable Exposure Symptoms: Severe irritation, delayed respiratory distress, persistent cough, skin ulceration from concentrated exposure
Ecotoxicity: Persistent in the environment, very high potential for bioaccumulation, toxic to aquatic organisms
Aquatic Toxicity: May cause immediate and long-term hazard to fish and aquatic invertebrates
Mobility In Soil: Low mobility, binds strongly but potential for water contamination due to slow hydrolysis
Persistence and Degradability: Resistant to biodegradation, perfluorinated chains are highly stable, environmental breakdown extremely slow
Bioaccumulative Potential: High due to perfluorinated backbone
Other Adverse Effects: Degradation products can include perfluorobutane sulfonate, a persistent organic pollutant
Regulatory Information: Increasing restrictions on use/discharge of perfluorinated substances globally, reporting may be required for spills or releases
Disposal Methods: Treat as hazardous chemical waste, incinerate at high temperature in licensed facility with scrubbing for hydrogen fluoride and sulfur oxides
Waste Codes: Use appropriate code for halogenated organic wastes
Container Disposal: Triple-rinse containers with appropriate solvent under controlled conditions, dispose of rinsate as hazardous waste
Environmental Release: Do not allow to enter sewers, surface water, or soil
Contaminated Packaging: Dispose in accordance with local regulations; do not reuse unless professionally decontaminated
Special Instructions: Consult local environmental protection agencies for guidelines; ensure traceability of hazardous waste streams
Minimize Waste: Use only amount needed; recycle excess when possible
UN Number: 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains Perfluorobutanesulfonyl fluoride)
Transport Hazard Class: 8 (Corrosive substance)
Packing Group: II
Labels Required: Corrosive, Environmental hazard (if required by local regulations)
Special Precautions for Transport: Keep containers upright and secure, inspect for leaks prior to loading, segregate from incompatible chemicals
Land (ADR/RID): Follows international rules for hazardous chemical transit
Air (IATA): Permitted with restrictions, use only via certified shipper
Maritime (IMDG): Marine pollutant, special stowage requirements; follow safety data sheet in case of spill or container compromise
Emergency Response Code: Refer to chemical emergency guides for appropriate response to release or accident during transit
OSHA: Listed as hazardous per OSHA Hazard Communication Standard
TSCA: Listed on the Toxic Substances Control Act inventory in the United States
REACH: Requires registration in the European Union, subject to ongoing review, increasing regulatory oversight for PFAS compounds
SARA Title III (Sections 311/312): Immediate (acute) health hazard, delayed (chronic) health hazard
California Proposition 65: Not currently listed, but related sulfonyl fluorides and PFAS may be considered for future listings
Canadian DSL: Included on Domestic Substances List
Other Regulations: Regulated as a hazardous substance in most jurisdictions worldwide due to persistence and toxicity
Workplace Safety: Workers must be trained in safe handling, storage, and emergency procedures
Environmental Release Reporting: Required for significant spills in most countries; always consult local laws
Import/Export Requirements: Many jurisdictions require pre-shipment notification for PFAS chemicals
